Successful Salvage Chemotherapy with Streptozocin in a Patient with Mediastinal Atypical Carcinoid Tumor Who Had Relapsed after Various Prior Therapies
Pulmonary neuroendocrine tumors are rare, and there have been very few reports regarding optimal chemotherapeutic regimens. Two molecular targeted agents, everolimus and sunitinib, have recently been shown to provide an additional treatment benefit for pulmonary neuroendocrine tumors. However, littl...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2018-01-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/477163 |
| _version_ | 1811313361912070144 |
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| author | Toshirou Fukushima Daisuke Gomi Noriko Seno Takahiko Gibo Takashi Kobayashi Nodoka Sekiguchi Hirohide Matsushita Yoshiko Kasahara Keiko Mamiya Tomonobu Koizumi |
| author_facet | Toshirou Fukushima Daisuke Gomi Noriko Seno Takahiko Gibo Takashi Kobayashi Nodoka Sekiguchi Hirohide Matsushita Yoshiko Kasahara Keiko Mamiya Tomonobu Koizumi |
| author_sort | Toshirou Fukushima |
| collection | DOAJ |
| description | Pulmonary neuroendocrine tumors are rare, and there have been very few reports regarding optimal chemotherapeutic regimens. Two molecular targeted agents, everolimus and sunitinib, have recently been shown to provide an additional treatment benefit for pulmonary neuroendocrine tumors. However, little information is available regarding the usefulness of streptozocin chemotherapy. Here, we encountered a case of relapsed and refractory mediastinal atypical carcinoid tumor associated with multiple endocrine neoplasia type 1 for various cytotoxic and molecular targeted agents. The patient showed a good response to streptozocin monotherapy. We describe the case and review streptozocin chemotherapy in patients with pulmonary neuroendocrine tumors. |
| first_indexed | 2024-04-13T10:53:33Z |
| format | Article |
| id | doaj.art-8f51e384ae704d8589f294ed62c7e7b8 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-13T10:53:33Z |
| publishDate | 2018-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-8f51e384ae704d8589f294ed62c7e7b82022-12-22T02:49:36ZengKarger PublishersCase Reports in Oncology1662-65752018-01-01111495410.1159/000477163477163Successful Salvage Chemotherapy with Streptozocin in a Patient with Mediastinal Atypical Carcinoid Tumor Who Had Relapsed after Various Prior TherapiesToshirou FukushimaDaisuke GomiNoriko SenoTakahiko GiboTakashi KobayashiNodoka SekiguchiHirohide MatsushitaYoshiko KasaharaKeiko MamiyaTomonobu KoizumiPulmonary neuroendocrine tumors are rare, and there have been very few reports regarding optimal chemotherapeutic regimens. Two molecular targeted agents, everolimus and sunitinib, have recently been shown to provide an additional treatment benefit for pulmonary neuroendocrine tumors. However, little information is available regarding the usefulness of streptozocin chemotherapy. Here, we encountered a case of relapsed and refractory mediastinal atypical carcinoid tumor associated with multiple endocrine neoplasia type 1 for various cytotoxic and molecular targeted agents. The patient showed a good response to streptozocin monotherapy. We describe the case and review streptozocin chemotherapy in patients with pulmonary neuroendocrine tumors.https://www.karger.com/Article/FullText/477163Multiple endocrine neoplasia type 1ChemotherapyEverolimusSunitinibMediastinal tumor |
| spellingShingle | Toshirou Fukushima Daisuke Gomi Noriko Seno Takahiko Gibo Takashi Kobayashi Nodoka Sekiguchi Hirohide Matsushita Yoshiko Kasahara Keiko Mamiya Tomonobu Koizumi Successful Salvage Chemotherapy with Streptozocin in a Patient with Mediastinal Atypical Carcinoid Tumor Who Had Relapsed after Various Prior Therapies Case Reports in Oncology Multiple endocrine neoplasia type 1 Chemotherapy Everolimus Sunitinib Mediastinal tumor |
| title | Successful Salvage Chemotherapy with Streptozocin in a Patient with Mediastinal Atypical Carcinoid Tumor Who Had Relapsed after Various Prior Therapies |
| title_full | Successful Salvage Chemotherapy with Streptozocin in a Patient with Mediastinal Atypical Carcinoid Tumor Who Had Relapsed after Various Prior Therapies |
| title_fullStr | Successful Salvage Chemotherapy with Streptozocin in a Patient with Mediastinal Atypical Carcinoid Tumor Who Had Relapsed after Various Prior Therapies |
| title_full_unstemmed | Successful Salvage Chemotherapy with Streptozocin in a Patient with Mediastinal Atypical Carcinoid Tumor Who Had Relapsed after Various Prior Therapies |
| title_short | Successful Salvage Chemotherapy with Streptozocin in a Patient with Mediastinal Atypical Carcinoid Tumor Who Had Relapsed after Various Prior Therapies |
| title_sort | successful salvage chemotherapy with streptozocin in a patient with mediastinal atypical carcinoid tumor who had relapsed after various prior therapies |
| topic | Multiple endocrine neoplasia type 1 Chemotherapy Everolimus Sunitinib Mediastinal tumor |
| url | https://www.karger.com/Article/FullText/477163 |
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