Ketamine: Pro or antiepileptic agent? A systematic review
Purpose: of Review: This evidence-based systematic review evaluated the safety of ketamine as regard the potential to provoke epilepsy to help better guide anesthesiologists in their practice. Recent findings: Ketamine, originally developed as a dissociative anesthetic, has gained attention for its...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402400464X |
| _version_ | 1797328675789602816 |
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| author | Islam Mohammad Shehata Neveen A. Kohaf Mohamed W. ElSayed Kaveh Latifi Aya Moustafa Aboutaleb Alan David Kaye |
| author_facet | Islam Mohammad Shehata Neveen A. Kohaf Mohamed W. ElSayed Kaveh Latifi Aya Moustafa Aboutaleb Alan David Kaye |
| author_sort | Islam Mohammad Shehata |
| collection | DOAJ |
| description | Purpose: of Review: This evidence-based systematic review evaluated the safety of ketamine as regard the potential to provoke epilepsy to help better guide anesthesiologists in their practice. Recent findings: Ketamine, originally developed as a dissociative anesthetic, has gained attention for its potential therapeutic applications in various medical conditions, including epilepsy. Ketamine is generally well-tolerated and widely used in anesthesia, however, conflicting data are confusing the anesthesiologists regarding the potential risk of seizures associated with its use. The literature that claimed the proepileeptic property are inconsistent and the mechanism of action is unclear. Moreover, the case reports had been in same certain contexts, such as procedural sedation where ketamine was used as a single agent. On the other hand, the retrospective data analysis confirmed the positive role ketamine plays as antiepileptic agent. Summary: Many studies have shown promising results for the use of ketamine as antiepileptic agent. In case of epileptic patients, there is no contraindication for using ketamine, however, combining with benzodiazepine or propofol may enhance the safety. |
| first_indexed | 2024-03-08T06:55:07Z |
| format | Article |
| id | doaj.art-8f52741b8f7143da90bdfbc69170ec98 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T06:55:07Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-8f52741b8f7143da90bdfbc69170ec982024-02-03T06:37:26ZengElsevierHeliyon2405-84402024-01-01102e24433Ketamine: Pro or antiepileptic agent? A systematic reviewIslam Mohammad Shehata0Neveen A. Kohaf1Mohamed W. ElSayed2Kaveh Latifi3Aya Moustafa Aboutaleb4Alan David Kaye5Ain Shams University, Cairo, Egypt; Corresponding author.Department of Clinical Pharmacy, Alazhar, University, Cairo, 11651, EgyptGeisel School of Medicine at Dartmouth, New Hampshire Hospital, SUNY School of Graduate Studies, USADepartment of Anesthesiology and Pain Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, IranZagazig University, Zagazig, EgyptDepartments of Anesthesiology and Pharmacology, Toxicology, and Neurosciences, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, 71103, USAPurpose: of Review: This evidence-based systematic review evaluated the safety of ketamine as regard the potential to provoke epilepsy to help better guide anesthesiologists in their practice. Recent findings: Ketamine, originally developed as a dissociative anesthetic, has gained attention for its potential therapeutic applications in various medical conditions, including epilepsy. Ketamine is generally well-tolerated and widely used in anesthesia, however, conflicting data are confusing the anesthesiologists regarding the potential risk of seizures associated with its use. The literature that claimed the proepileeptic property are inconsistent and the mechanism of action is unclear. Moreover, the case reports had been in same certain contexts, such as procedural sedation where ketamine was used as a single agent. On the other hand, the retrospective data analysis confirmed the positive role ketamine plays as antiepileptic agent. Summary: Many studies have shown promising results for the use of ketamine as antiepileptic agent. In case of epileptic patients, there is no contraindication for using ketamine, however, combining with benzodiazepine or propofol may enhance the safety.http://www.sciencedirect.com/science/article/pii/S240584402400464XKetamineEpilepsyAnesthesiaSedation |
| spellingShingle | Islam Mohammad Shehata Neveen A. Kohaf Mohamed W. ElSayed Kaveh Latifi Aya Moustafa Aboutaleb Alan David Kaye Ketamine: Pro or antiepileptic agent? A systematic review Heliyon Ketamine Epilepsy Anesthesia Sedation |
| title | Ketamine: Pro or antiepileptic agent? A systematic review |
| title_full | Ketamine: Pro or antiepileptic agent? A systematic review |
| title_fullStr | Ketamine: Pro or antiepileptic agent? A systematic review |
| title_full_unstemmed | Ketamine: Pro or antiepileptic agent? A systematic review |
| title_short | Ketamine: Pro or antiepileptic agent? A systematic review |
| title_sort | ketamine pro or antiepileptic agent a systematic review |
| topic | Ketamine Epilepsy Anesthesia Sedation |
| url | http://www.sciencedirect.com/science/article/pii/S240584402400464X |
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