Phytoimmunomodulators: A review of natural modulators for complex immune system
In the past few decades, the medicinal properties of plants and their effects on the human immune system are being studied extensively. Plants are an incredible source of traditional medicines that help cure various diseases, including altered immune mechanisms and are economical and benign compared...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023109984 |
| _version_ | 1827367166234591232 |
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| author | Partibha Hooda Rohit Malik Saurabh Bhatia Ahmed Al-Harrasi Asim Najmi Khalid Zoghebi Maryam A. Halawi Hafiz A. Makeen Syam Mohan |
| author_facet | Partibha Hooda Rohit Malik Saurabh Bhatia Ahmed Al-Harrasi Asim Najmi Khalid Zoghebi Maryam A. Halawi Hafiz A. Makeen Syam Mohan |
| author_sort | Partibha Hooda |
| collection | DOAJ |
| description | In the past few decades, the medicinal properties of plants and their effects on the human immune system are being studied extensively. Plants are an incredible source of traditional medicines that help cure various diseases, including altered immune mechanisms and are economical and benign compared to allopathic medicines. Reported data in written documents such as Traditional Chinese medicine, Indian Ayurvedic medicine support the supplementation of botanicals for immune defense reactions in the body and can lead to safe and effective immunity responses. Additionally, some botanicals are well-identified as magical herbal remedies because they act upon the pathogen directly and help boost the immunity of the host. Chemical compounds, also known as phytochemicals, obtained from these botanicals looked promising due to their effects on the human immune system by modulating the lymphocytes which subsequently reduce the chances of getting infected. This paper summarises most documented phytochemicals and how they act on the immune system, their properties and possible mechanisms, screening conventions, formulation guidelines, comparison with synthetic immunity-enhancers, marketed immunity-boosting products, and immune-booster role in the ongoing ghastly corona virus wave. However, it focuses mainly on plant metabolites as immunomodulators. In addition, it also sheds light on the current advancements and future possibilities in this field. From this thorough study, it can be stated that the plant-based secondary metabolites contribute significantly to immunity building and could prove to be valuable medicaments for the design and development of novel immunomodulators even for a pandemic like COVID-19. |
| first_indexed | 2024-03-08T09:02:39Z |
| format | Article |
| id | doaj.art-8f539227c506482c91be59ee8df0fa9e |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T09:02:39Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-8f539227c506482c91be59ee8df0fa9e2024-02-01T06:33:32ZengElsevierHeliyon2405-84402024-01-01101e23790Phytoimmunomodulators: A review of natural modulators for complex immune systemPartibha Hooda0Rohit Malik1Saurabh Bhatia2Ahmed Al-Harrasi3Asim Najmi4Khalid Zoghebi5Maryam A. Halawi6Hafiz A. Makeen7Syam Mohan8Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, IndiaGurugram Global College of Pharmacy, Gurugram, India; SRM Modi Nagar College of Pharmacy, SRMIST, Delhi-NCR Campus, Ghaziabad, India; Corresponding author. SRM Modi Nagar College of Pharmacy, SRMIST, Delhi-NCR Campus, Ghaziabad, India.School of Health Science, University of Petroleum and Energy Studies, Dehradun, Uttarakhand, India; Natural & Medical Sciences Research Centre, University of Nizwa, Birkat Al Mauz, OmanNatural & Medical Sciences Research Centre, University of Nizwa, Birkat Al Mauz, OmanDepartment of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, P.O. Box 114, Jazan, Saudi ArabiaDepartment of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, P.O. Box 114, Jazan, Saudi ArabiaDepartment of Clinical pharmacy, College of Pharmacy, Jazan University, P.O. Box 114, Jazan, Saudi ArabiaDepartment of Clinical pharmacy, College of Pharmacy, Jazan University, P.O. Box 114, Jazan, Saudi ArabiaSubstance Abuse and Toxicology Research Centre, Jazan University, Jazan, Saudi Arabia; Center for Global health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India; Corresponding author. Substance Abuse and Toxicology Research Centre, Jazan University, Jazan, Saudi Arabia.In the past few decades, the medicinal properties of plants and their effects on the human immune system are being studied extensively. Plants are an incredible source of traditional medicines that help cure various diseases, including altered immune mechanisms and are economical and benign compared to allopathic medicines. Reported data in written documents such as Traditional Chinese medicine, Indian Ayurvedic medicine support the supplementation of botanicals for immune defense reactions in the body and can lead to safe and effective immunity responses. Additionally, some botanicals are well-identified as magical herbal remedies because they act upon the pathogen directly and help boost the immunity of the host. Chemical compounds, also known as phytochemicals, obtained from these botanicals looked promising due to their effects on the human immune system by modulating the lymphocytes which subsequently reduce the chances of getting infected. This paper summarises most documented phytochemicals and how they act on the immune system, their properties and possible mechanisms, screening conventions, formulation guidelines, comparison with synthetic immunity-enhancers, marketed immunity-boosting products, and immune-booster role in the ongoing ghastly corona virus wave. However, it focuses mainly on plant metabolites as immunomodulators. In addition, it also sheds light on the current advancements and future possibilities in this field. From this thorough study, it can be stated that the plant-based secondary metabolites contribute significantly to immunity building and could prove to be valuable medicaments for the design and development of novel immunomodulators even for a pandemic like COVID-19.http://www.sciencedirect.com/science/article/pii/S2405844023109984PhytoimmunomodulatorsSecondary metabolitesAyurvedaTraditional Chinese medicineCOVID-19Immunomodulators |
| spellingShingle | Partibha Hooda Rohit Malik Saurabh Bhatia Ahmed Al-Harrasi Asim Najmi Khalid Zoghebi Maryam A. Halawi Hafiz A. Makeen Syam Mohan Phytoimmunomodulators: A review of natural modulators for complex immune system Heliyon Phytoimmunomodulators Secondary metabolites Ayurveda Traditional Chinese medicine COVID-19 Immunomodulators |
| title | Phytoimmunomodulators: A review of natural modulators for complex immune system |
| title_full | Phytoimmunomodulators: A review of natural modulators for complex immune system |
| title_fullStr | Phytoimmunomodulators: A review of natural modulators for complex immune system |
| title_full_unstemmed | Phytoimmunomodulators: A review of natural modulators for complex immune system |
| title_short | Phytoimmunomodulators: A review of natural modulators for complex immune system |
| title_sort | phytoimmunomodulators a review of natural modulators for complex immune system |
| topic | Phytoimmunomodulators Secondary metabolites Ayurveda Traditional Chinese medicine COVID-19 Immunomodulators |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023109984 |
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