Influence of pro-obesogenic dietary habits on stress-induced cognitive alterations in healthy adult volunteers
Stress is a fundamental biological response that can be associated with alterations in cognitive processes. Unhealthy dietary habits are proposed to modulate this effect, notably through their pro-inflammatory potential. This cross-sectional study aimed to evaluate the influence of an obesogenic die...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Neurobiology of Stress |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352289521000618 |
| _version_ | 1819239040337051648 |
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| author | Inês Delgado Sandra Dexpert Julie Sauvant John F. Cryan Lucile Capuron |
| author_facet | Inês Delgado Sandra Dexpert Julie Sauvant John F. Cryan Lucile Capuron |
| author_sort | Inês Delgado |
| collection | DOAJ |
| description | Stress is a fundamental biological response that can be associated with alterations in cognitive processes. Unhealthy dietary habits are proposed to modulate this effect, notably through their pro-inflammatory potential. This cross-sectional study aimed to evaluate the influence of an obesogenic dietary pattern with inflammatory potential on stress-induced cognitive alterations in healthy volunteers.Fifty healthy adult participants were stratified into two diet groups: obesogenic vs. non-obesogenic, based on their self-reported consumption of fat, sugar, and salt, assessed by the French National Program for Nutrition and Health questionnaire and a food frequency questionnaire. Serum high-sensitive C-reactive protein (hsCRP) was measured as a marker of systemic inflammation using ELISA. Verbal memory and sustained attention were evaluated through the Verbal Recognition Memory (VRM) test and the Rapid Visual Information Processing (RVP) test respectively, from the Cambridge Neuropsychological Test Automated Battery. Assessments were performed before and after exposure to the psychological stressor Trier Social Stress Test (TSST). Stress response was evaluated by subjective stress perception, salivary cortisol, blood pressure, and heart rate.Twenty-two participants (44%) presented an obesogenic diet. Systemic inflammation was significantly higher in the obesogenic diet group (p=0.005). The TSST induced a significant stress response, regardless of dietary habits (Time effect p < 0.001). In the whole sample, exposure to TSST was associated with cognitive changes in the form of impaired performance on the VRM test and overall improved RVP scores. However, the obesogenic diet group exhibited an increased total number of false alarms (Time x Diet: p=0.014) on the RVP test after TSST exposure as well as a greater impairment in immediate verbal recognition on the VRM test (Time x Diet: p=0.002). This effect was not associated with the inflammatory component of the obesogenic diet.These results suggest that an obesogenic diet may sensitize healthy individuals to the detrimental effects of acute stress on cognitive performance. |
| first_indexed | 2024-12-23T13:45:48Z |
| format | Article |
| id | doaj.art-8f545b967ad340e5840b05d90e377d8f |
| institution | Directory Open Access Journal |
| issn | 2352-2895 |
| language | English |
| last_indexed | 2024-12-23T13:45:48Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Stress |
| spelling | doaj.art-8f545b967ad340e5840b05d90e377d8f2022-12-21T17:44:43ZengElsevierNeurobiology of Stress2352-28952021-11-0115100353Influence of pro-obesogenic dietary habits on stress-induced cognitive alterations in healthy adult volunteersInês Delgado0Sandra Dexpert1Julie Sauvant2John F. Cryan3Lucile Capuron4Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33000, Bordeaux, FranceUniv. Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33000, Bordeaux, FranceUniv. Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33000, Bordeaux, FranceAPC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy & Neuroscience, University College Cork, Cork, IrelandUniv. Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33000, Bordeaux, France; Corresponding author. Laboratory of Nutrition and Integrative Neurobiology (NutriNeuro) University of Bordeaux, 146 rue Léo Saignat F-33076 Bordeaux, France.Stress is a fundamental biological response that can be associated with alterations in cognitive processes. Unhealthy dietary habits are proposed to modulate this effect, notably through their pro-inflammatory potential. This cross-sectional study aimed to evaluate the influence of an obesogenic dietary pattern with inflammatory potential on stress-induced cognitive alterations in healthy volunteers.Fifty healthy adult participants were stratified into two diet groups: obesogenic vs. non-obesogenic, based on their self-reported consumption of fat, sugar, and salt, assessed by the French National Program for Nutrition and Health questionnaire and a food frequency questionnaire. Serum high-sensitive C-reactive protein (hsCRP) was measured as a marker of systemic inflammation using ELISA. Verbal memory and sustained attention were evaluated through the Verbal Recognition Memory (VRM) test and the Rapid Visual Information Processing (RVP) test respectively, from the Cambridge Neuropsychological Test Automated Battery. Assessments were performed before and after exposure to the psychological stressor Trier Social Stress Test (TSST). Stress response was evaluated by subjective stress perception, salivary cortisol, blood pressure, and heart rate.Twenty-two participants (44%) presented an obesogenic diet. Systemic inflammation was significantly higher in the obesogenic diet group (p=0.005). The TSST induced a significant stress response, regardless of dietary habits (Time effect p < 0.001). In the whole sample, exposure to TSST was associated with cognitive changes in the form of impaired performance on the VRM test and overall improved RVP scores. However, the obesogenic diet group exhibited an increased total number of false alarms (Time x Diet: p=0.014) on the RVP test after TSST exposure as well as a greater impairment in immediate verbal recognition on the VRM test (Time x Diet: p=0.002). This effect was not associated with the inflammatory component of the obesogenic diet.These results suggest that an obesogenic diet may sensitize healthy individuals to the detrimental effects of acute stress on cognitive performance.http://www.sciencedirect.com/science/article/pii/S2352289521000618Obesogenic dietInflammationAcute stressVerbal memorySustained attention |
| spellingShingle | Inês Delgado Sandra Dexpert Julie Sauvant John F. Cryan Lucile Capuron Influence of pro-obesogenic dietary habits on stress-induced cognitive alterations in healthy adult volunteers Neurobiology of Stress Obesogenic diet Inflammation Acute stress Verbal memory Sustained attention |
| title | Influence of pro-obesogenic dietary habits on stress-induced cognitive alterations in healthy adult volunteers |
| title_full | Influence of pro-obesogenic dietary habits on stress-induced cognitive alterations in healthy adult volunteers |
| title_fullStr | Influence of pro-obesogenic dietary habits on stress-induced cognitive alterations in healthy adult volunteers |
| title_full_unstemmed | Influence of pro-obesogenic dietary habits on stress-induced cognitive alterations in healthy adult volunteers |
| title_short | Influence of pro-obesogenic dietary habits on stress-induced cognitive alterations in healthy adult volunteers |
| title_sort | influence of pro obesogenic dietary habits on stress induced cognitive alterations in healthy adult volunteers |
| topic | Obesogenic diet Inflammation Acute stress Verbal memory Sustained attention |
| url | http://www.sciencedirect.com/science/article/pii/S2352289521000618 |
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