Clinical, Histophatological, Laboratory, and Elastographic Findings and Treatment Outcome in Patients with Autoimmune Hepatitis in Sari, Iran
Background and purpose: Autoimmune hepatitis is a chronic liver inflammatory disease of unknown etiology that is more common in women. The goal of this study was to investigate the clinical, histopathological, laboratory, and elastography findings and outcome in patients with autoimmune hepatitis an...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mazandaran University of Medical Sciences
2022-05-01
|
| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-17062-en.html |
| _version_ | 1797893234755633152 |
|---|---|
| author | Mahboobe Ebrahimi Hafez tirgar Fakheri Tarang Taghvaei Iradj Maleki Vahid Hosseini Arash Kazemi Veisari Zohre Bari Hajar Shokri-Afra Sepehr tirgar Fakheri |
| author_facet | Mahboobe Ebrahimi Hafez tirgar Fakheri Tarang Taghvaei Iradj Maleki Vahid Hosseini Arash Kazemi Veisari Zohre Bari Hajar Shokri-Afra Sepehr tirgar Fakheri |
| author_sort | Mahboobe Ebrahimi |
| collection | DOAJ |
| description | Background and purpose: Autoimmune hepatitis is a chronic liver inflammatory disease of unknown etiology that is more common in women. The goal of this study was to investigate the clinical, histopathological, laboratory, and elastography findings and outcome in patients with autoimmune hepatitis and verifying the factors associated with treatment response in Sari, Iran.
Materials and methods: This research is a descriptive study in which demographic, clinical, histopathological, laboratory and elastographic information of 136 autoimmune hepatitis patients referred to Imam Khomeini Hospital and specialized gastrointestinal clinics in Sari during the years 2019-2021 was recorded in a pre-designed questionnaire.
Results: In the study of the relationship between demographic, laboratory, histopathological, elastographic, and clinical factors with response to treatment, only prothrombin time (PT) and platelet (PLT) count had a significant relationship with response to treatment (p < 0.05). In fact, thrombocytopenia and high PT led to poor treatment response and high PT was associated with a higher probability of recurrence. There was also a significant relationship between cirrhosis and non-cirrhosis at the time of diagnosis with response to treatment (p < 0.05). People with cirrhosis experienced less response to treatment. None of the factors mentioned were related to the new cirrhosis (p < 0.05). In the study of the relationship between the results of the initial and subsequent liver fibroscan during the follow-up, the reduction of fibrosis following treatment was clearly seen.
Conclusion: Liver elastography is recommended for fibrosis evaluation during treatment and follow-up. |
| first_indexed | 2024-04-10T06:49:38Z |
| format | Article |
| id | doaj.art-8f55ff91ab774a06a67a9317d002a07e |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T06:49:38Z |
| publishDate | 2022-05-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-8f55ff91ab774a06a67a9317d002a07e2023-02-28T08:45:25ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792022-05-0132209163174Clinical, Histophatological, Laboratory, and Elastographic Findings and Treatment Outcome in Patients with Autoimmune Hepatitis in Sari, IranMahboobe Ebrahimi0Hafez tirgar Fakheri1Tarang Taghvaei2Iradj Maleki3Vahid Hosseini4Arash Kazemi Veisari5Zohre Bari6Hajar Shokri-Afra7Sepehr tirgar Fakheri8 Assistant Professor, Gut and Liver Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Professor, Gut and Liver Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Gut and Liver Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Gut and Liver Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Associate Professor, Gut and Liver Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Assistant Professor, Gut and Liver Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Assistant Professor, Gut and Liver Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran PhD in Clinical Biochemistry, Gut and Liver Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran General Physician, Gut and Liver Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Background and purpose: Autoimmune hepatitis is a chronic liver inflammatory disease of unknown etiology that is more common in women. The goal of this study was to investigate the clinical, histopathological, laboratory, and elastography findings and outcome in patients with autoimmune hepatitis and verifying the factors associated with treatment response in Sari, Iran. Materials and methods: This research is a descriptive study in which demographic, clinical, histopathological, laboratory and elastographic information of 136 autoimmune hepatitis patients referred to Imam Khomeini Hospital and specialized gastrointestinal clinics in Sari during the years 2019-2021 was recorded in a pre-designed questionnaire. Results: In the study of the relationship between demographic, laboratory, histopathological, elastographic, and clinical factors with response to treatment, only prothrombin time (PT) and platelet (PLT) count had a significant relationship with response to treatment (p < 0.05). In fact, thrombocytopenia and high PT led to poor treatment response and high PT was associated with a higher probability of recurrence. There was also a significant relationship between cirrhosis and non-cirrhosis at the time of diagnosis with response to treatment (p < 0.05). People with cirrhosis experienced less response to treatment. None of the factors mentioned were related to the new cirrhosis (p < 0.05). In the study of the relationship between the results of the initial and subsequent liver fibroscan during the follow-up, the reduction of fibrosis following treatment was clearly seen. Conclusion: Liver elastography is recommended for fibrosis evaluation during treatment and follow-up.http://jmums.mazums.ac.ir/article-1-17062-en.htmlliver cirrhosiselastographytreatment failuresremission inductionsrecurrence |
| spellingShingle | Mahboobe Ebrahimi Hafez tirgar Fakheri Tarang Taghvaei Iradj Maleki Vahid Hosseini Arash Kazemi Veisari Zohre Bari Hajar Shokri-Afra Sepehr tirgar Fakheri Clinical, Histophatological, Laboratory, and Elastographic Findings and Treatment Outcome in Patients with Autoimmune Hepatitis in Sari, Iran Journal of Mazandaran University of Medical Sciences liver cirrhosis elastography treatment failures remission inductions recurrence |
| title | Clinical, Histophatological, Laboratory, and Elastographic Findings and Treatment Outcome in Patients with Autoimmune Hepatitis in Sari, Iran |
| title_full | Clinical, Histophatological, Laboratory, and Elastographic Findings and Treatment Outcome in Patients with Autoimmune Hepatitis in Sari, Iran |
| title_fullStr | Clinical, Histophatological, Laboratory, and Elastographic Findings and Treatment Outcome in Patients with Autoimmune Hepatitis in Sari, Iran |
| title_full_unstemmed | Clinical, Histophatological, Laboratory, and Elastographic Findings and Treatment Outcome in Patients with Autoimmune Hepatitis in Sari, Iran |
| title_short | Clinical, Histophatological, Laboratory, and Elastographic Findings and Treatment Outcome in Patients with Autoimmune Hepatitis in Sari, Iran |
| title_sort | clinical histophatological laboratory and elastographic findings and treatment outcome in patients with autoimmune hepatitis in sari iran |
| topic | liver cirrhosis elastography treatment failures remission inductions recurrence |
| url | http://jmums.mazums.ac.ir/article-1-17062-en.html |
| work_keys_str_mv | AT mahboobeebrahimi clinicalhistophatologicallaboratoryandelastographicfindingsandtreatmentoutcomeinpatientswithautoimmunehepatitisinsariiran AT hafeztirgarfakheri clinicalhistophatologicallaboratoryandelastographicfindingsandtreatmentoutcomeinpatientswithautoimmunehepatitisinsariiran AT tarangtaghvaei clinicalhistophatologicallaboratoryandelastographicfindingsandtreatmentoutcomeinpatientswithautoimmunehepatitisinsariiran AT iradjmaleki clinicalhistophatologicallaboratoryandelastographicfindingsandtreatmentoutcomeinpatientswithautoimmunehepatitisinsariiran AT vahidhosseini clinicalhistophatologicallaboratoryandelastographicfindingsandtreatmentoutcomeinpatientswithautoimmunehepatitisinsariiran AT arashkazemiveisari clinicalhistophatologicallaboratoryandelastographicfindingsandtreatmentoutcomeinpatientswithautoimmunehepatitisinsariiran AT zohrebari clinicalhistophatologicallaboratoryandelastographicfindingsandtreatmentoutcomeinpatientswithautoimmunehepatitisinsariiran AT hajarshokriafra clinicalhistophatologicallaboratoryandelastographicfindingsandtreatmentoutcomeinpatientswithautoimmunehepatitisinsariiran AT sepehrtirgarfakheri clinicalhistophatologicallaboratoryandelastographicfindingsandtreatmentoutcomeinpatientswithautoimmunehepatitisinsariiran |