Predictive value of serum progesterone level on β-hCG check day in women with previous repeated miscarriages after in vitro fertilization.
To evaluate the predictive value of the progesterone level at the beta-human chorionic gonadotropin (β-hCG) check day for ongoing pregnancy maintenance in in vitro fertilization (IVF) cycles in women with previous unexplained repeated miscarriages.One hundred and forty-eight women, with visible gest...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5510853?pdf=render |
| _version_ | 1819063560276279296 |
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| author | Yong Jin Kim Jung Ho Shin Jun Yong Hur Hoon Kim Seung-Yup Ku Chang Suk Suh |
| author_facet | Yong Jin Kim Jung Ho Shin Jun Yong Hur Hoon Kim Seung-Yup Ku Chang Suk Suh |
| author_sort | Yong Jin Kim |
| collection | DOAJ |
| description | To evaluate the predictive value of the progesterone level at the beta-human chorionic gonadotropin (β-hCG) check day for ongoing pregnancy maintenance in in vitro fertilization (IVF) cycles in women with previous unexplained repeated miscarriages.One hundred and forty-eight women, with visible gestational sac after IVF, were recruited in this observational study. All subjects had unexplained recurrent miscarriages in more than two previous IVF cycles. The progesterone level at the β-hCG check day (i.e. 14 days after oocyte retrieval) was assessed. The area under the curve (AUC) of the progesterone level was evaluated to predict the ongoing pregnancy or miscarriage outcomes.The overall ongoing pregnancy rate was 60.8% (90/148). The cut-off value with β-hCG levels higher than 126.5 mIU/mL and with progesterone levels higher than 25.2 ng/mL could be the predictive factors for ongoing pregnancy maintenance (AUC = 0.788 and 0.826; sensitivity = 0.788 and 0.723; specificity = 0.689 and 0.833; P < 0.0001 and P < 0.0001, respectively). The miscarriage rates were 19.5% (15/77) in the women with β-hCG > 126.5 mIU/mL and 13.0% (10/77) in those with > 25.2 ng/mL. In the comparison of the ROC curves between both values, a similar significance was found. The subjects with β-hCG > 126.5 mIU/mL and progesterone > 25.2 ng/mL showed higher ongoing pregnancy rates [98.0% (49/50) vs. 41.8% (41/98)] than those with β-hCG ≤ 126.5 mIU/mL or progesterone ≤ 25.2 ng/mL.The progesterone level at 14 days after oocyte retrieval can be a good predictive marker for ongoing pregnancy maintenance in women with repeated IVF failure with miscarriage, together with the β-hCG level. The combined cut-off value of progesterone > 25.2 ng/mL and β-hCG > 126.5 mIU/mL may suggest a good prognosis. |
| first_indexed | 2024-12-21T15:16:37Z |
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| id | doaj.art-8f568803f14549069a49d7a805895c22 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T15:16:37Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-8f568803f14549069a49d7a805895c222022-12-21T18:59:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01127e018122910.1371/journal.pone.0181229Predictive value of serum progesterone level on β-hCG check day in women with previous repeated miscarriages after in vitro fertilization.Yong Jin KimJung Ho ShinJun Yong HurHoon KimSeung-Yup KuChang Suk SuhTo evaluate the predictive value of the progesterone level at the beta-human chorionic gonadotropin (β-hCG) check day for ongoing pregnancy maintenance in in vitro fertilization (IVF) cycles in women with previous unexplained repeated miscarriages.One hundred and forty-eight women, with visible gestational sac after IVF, were recruited in this observational study. All subjects had unexplained recurrent miscarriages in more than two previous IVF cycles. The progesterone level at the β-hCG check day (i.e. 14 days after oocyte retrieval) was assessed. The area under the curve (AUC) of the progesterone level was evaluated to predict the ongoing pregnancy or miscarriage outcomes.The overall ongoing pregnancy rate was 60.8% (90/148). The cut-off value with β-hCG levels higher than 126.5 mIU/mL and with progesterone levels higher than 25.2 ng/mL could be the predictive factors for ongoing pregnancy maintenance (AUC = 0.788 and 0.826; sensitivity = 0.788 and 0.723; specificity = 0.689 and 0.833; P < 0.0001 and P < 0.0001, respectively). The miscarriage rates were 19.5% (15/77) in the women with β-hCG > 126.5 mIU/mL and 13.0% (10/77) in those with > 25.2 ng/mL. In the comparison of the ROC curves between both values, a similar significance was found. The subjects with β-hCG > 126.5 mIU/mL and progesterone > 25.2 ng/mL showed higher ongoing pregnancy rates [98.0% (49/50) vs. 41.8% (41/98)] than those with β-hCG ≤ 126.5 mIU/mL or progesterone ≤ 25.2 ng/mL.The progesterone level at 14 days after oocyte retrieval can be a good predictive marker for ongoing pregnancy maintenance in women with repeated IVF failure with miscarriage, together with the β-hCG level. The combined cut-off value of progesterone > 25.2 ng/mL and β-hCG > 126.5 mIU/mL may suggest a good prognosis.http://europepmc.org/articles/PMC5510853?pdf=render |
| spellingShingle | Yong Jin Kim Jung Ho Shin Jun Yong Hur Hoon Kim Seung-Yup Ku Chang Suk Suh Predictive value of serum progesterone level on β-hCG check day in women with previous repeated miscarriages after in vitro fertilization. PLoS ONE |
| title | Predictive value of serum progesterone level on β-hCG check day in women with previous repeated miscarriages after in vitro fertilization. |
| title_full | Predictive value of serum progesterone level on β-hCG check day in women with previous repeated miscarriages after in vitro fertilization. |
| title_fullStr | Predictive value of serum progesterone level on β-hCG check day in women with previous repeated miscarriages after in vitro fertilization. |
| title_full_unstemmed | Predictive value of serum progesterone level on β-hCG check day in women with previous repeated miscarriages after in vitro fertilization. |
| title_short | Predictive value of serum progesterone level on β-hCG check day in women with previous repeated miscarriages after in vitro fertilization. |
| title_sort | predictive value of serum progesterone level on β hcg check day in women with previous repeated miscarriages after in vitro fertilization |
| url | http://europepmc.org/articles/PMC5510853?pdf=render |
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