Fragment-Based Structural Optimization of a Natural Product Itampolin A as a p38α Inhibitor for Lung Cancer

Fragment-Based Structural Optimization of a Natural Product Itampolin A as a p38α Inhibitor for Lung Cancer

Marine animals and plants provide abundant secondary metabolites with antitumor activity. Itampolin A is a brominated natural tyrosine secondary metabolite that is isolated from the sponge Iotrochota purpurea. Recently, we have achieved the first total synthesis of this brominated tyrosine secondary...

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Bibliographic Details
Main Authors:	Jing-wei Liang, Ming-yang Wang, Shan Wang, Xin-yang Li, Fan-hao Meng
Format:	Article
Language:	English
Published:	MDPI AG 2019-01-01
Series:	Marine Drugs
Subjects:	itampolin A FBDD antitumor p38α novel inhibitor
Online Access:	http://www.mdpi.com/1660-3397/17/1/53

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