Analysis of cardiovascular risk and carotid intima-media thickness in patients with psoriasis,
Abstract Background: Psoriasis is associated with atherosclerosis and increased cardiovascular risk. Currently, an automated ultrasound, called quantitative intima media thickness, has proven to be a useful method to evaluate subclinical atherosclerosis. Objectives: To compare increased cardiovasc...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Dermatologia
2020-07-01
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| Series: | Anais Brasileiros de Dermatologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/pdf/abd/v95n2/0365-0596-abd-95-02-0150.pdf |
| _version_ | 1811191564619218944 |
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| author | Elaine Cristina Faria Abrahão-Machado José Alexandre Mendonça Ana Carolina Belini Bazán Arruda Luciana Bertoldi Nucci Marcel Alex Soares dos Santos |
| author_facet | Elaine Cristina Faria Abrahão-Machado José Alexandre Mendonça Ana Carolina Belini Bazán Arruda Luciana Bertoldi Nucci Marcel Alex Soares dos Santos |
| author_sort | Elaine Cristina Faria Abrahão-Machado |
| collection | DOAJ |
| description | Abstract Background: Psoriasis is associated with atherosclerosis and increased cardiovascular risk. Currently, an automated ultrasound, called quantitative intima media thickness, has proven to be a useful method to evaluate subclinical atherosclerosis. Objectives: To compare increased cardiovascular risk in psoriasis patients receiving two types of treatments: Methotrexate and tumor necrosis factor inhibitor and to evaluate the correlation between the Framingham score and quantitative intima media thickness. Methods: Fifty patients with plaque psoriasis were selected from June 2017 to July 2018, divided into two groups, receiving methotrexate and tumor necrosis factor inhibitor. Measurement of abdominal circumference, blood pressure, body mass index and presence of metabolic syndrome were performed. Afterwards, the patients were evaluated for increased cardiovascular risk with the Framingham score and for the quantitative intima media thickness of the carotid arteries. Results: The mean age was 54.8 (±12.5) with a slight male predominance (58%). Overall, 84% of the patients had elevated waist circumference, 82% had a body mass index above ideal, and 50% had a metabolic syndrome. For the correlation between quantitative intima media thickness and Framingham Score, Pearson's linear correlation coefficient was 0.617 (p < 0.001), indicating a moderate to strong positive association. Study limitations: The protective effect of the therapies cited in relation to the increased cardiovascular risk was not evaluated. Conclusions: A moderate to strong positive association was found correlating the Framingham Score values with the quantitative intima media thickness measurement and it is not possible to state which drug has the highest increased cardiovascular risk. |
| first_indexed | 2024-04-11T20:17:11Z |
| format | Article |
| id | doaj.art-8f585cf1713b41ab804d67a342c3879e |
| institution | Directory Open Access Journal |
| issn | 0365-0596 |
| language | English |
| last_indexed | 2024-04-11T20:17:11Z |
| publishDate | 2020-07-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj.art-8f585cf1713b41ab804d67a342c3879e2022-12-22T04:04:55ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962020-07-0195215015710.1016/j.abd.2019.07.004Analysis of cardiovascular risk and carotid intima-media thickness in patients with psoriasis,Elaine Cristina Faria Abrahão-Machadohttps://orcid.org/0000-0003-1389-5977José Alexandre Mendonçahttps://orcid.org/0000-0003-1689-6705Ana Carolina Belini Bazán Arrudahttps://orcid.org/0000-0002-0371-2308Luciana Bertoldi Nuccihttps://orcid.org/0000-0002-5140-3622Marcel Alex Soares dos Santoshttps://orcid.org/0000-0002-5589-0931Abstract Background: Psoriasis is associated with atherosclerosis and increased cardiovascular risk. Currently, an automated ultrasound, called quantitative intima media thickness, has proven to be a useful method to evaluate subclinical atherosclerosis. Objectives: To compare increased cardiovascular risk in psoriasis patients receiving two types of treatments: Methotrexate and tumor necrosis factor inhibitor and to evaluate the correlation between the Framingham score and quantitative intima media thickness. Methods: Fifty patients with plaque psoriasis were selected from June 2017 to July 2018, divided into two groups, receiving methotrexate and tumor necrosis factor inhibitor. Measurement of abdominal circumference, blood pressure, body mass index and presence of metabolic syndrome were performed. Afterwards, the patients were evaluated for increased cardiovascular risk with the Framingham score and for the quantitative intima media thickness of the carotid arteries. Results: The mean age was 54.8 (±12.5) with a slight male predominance (58%). Overall, 84% of the patients had elevated waist circumference, 82% had a body mass index above ideal, and 50% had a metabolic syndrome. For the correlation between quantitative intima media thickness and Framingham Score, Pearson's linear correlation coefficient was 0.617 (p < 0.001), indicating a moderate to strong positive association. Study limitations: The protective effect of the therapies cited in relation to the increased cardiovascular risk was not evaluated. Conclusions: A moderate to strong positive association was found correlating the Framingham Score values with the quantitative intima media thickness measurement and it is not possible to state which drug has the highest increased cardiovascular risk.http://www.scielo.br/pdf/abd/v95n2/0365-0596-abd-95-02-0150.pdfCardiovascular diseasesCarotid intima-media thicknessMethotrexateMolecular targeted therapyPsoriasisUltrasonography |
| spellingShingle | Elaine Cristina Faria Abrahão-Machado José Alexandre Mendonça Ana Carolina Belini Bazán Arruda Luciana Bertoldi Nucci Marcel Alex Soares dos Santos Analysis of cardiovascular risk and carotid intima-media thickness in patients with psoriasis, Anais Brasileiros de Dermatologia Cardiovascular diseases Carotid intima-media thickness Methotrexate Molecular targeted therapy Psoriasis Ultrasonography |
| title | Analysis of cardiovascular risk and carotid intima-media thickness in patients with psoriasis, |
| title_full | Analysis of cardiovascular risk and carotid intima-media thickness in patients with psoriasis, |
| title_fullStr | Analysis of cardiovascular risk and carotid intima-media thickness in patients with psoriasis, |
| title_full_unstemmed | Analysis of cardiovascular risk and carotid intima-media thickness in patients with psoriasis, |
| title_short | Analysis of cardiovascular risk and carotid intima-media thickness in patients with psoriasis, |
| title_sort | analysis of cardiovascular risk and carotid intima media thickness in patients with psoriasis |
| topic | Cardiovascular diseases Carotid intima-media thickness Methotrexate Molecular targeted therapy Psoriasis Ultrasonography |
| url | http://www.scielo.br/pdf/abd/v95n2/0365-0596-abd-95-02-0150.pdf |
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