Effect of lansoprazole on human sperm motility, sperm viability, seminal nitric oxide production, and seminal calcium chelation
Lansoprazole is a proton-pump inhibitor that is commonly used to treat many gastric illnesses. However, little is known about its effect on sperm function. Here, we investigated the in vitro effect of LP on human sperm motility, viability, nitric oxide (NO) production, and the ability of LP to chela...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Research in Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2018;volume=13;issue=5;spage=460;epage=468;aulast=Banihani |
| _version_ | 1818864622819606528 |
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| author | Saleem Ali Banihani Falak Hisham Khasawneh |
| author_facet | Saleem Ali Banihani Falak Hisham Khasawneh |
| author_sort | Saleem Ali Banihani |
| collection | DOAJ |
| description | Lansoprazole is a proton-pump inhibitor that is commonly used to treat many gastric illnesses. However, little is known about its effect on sperm function. Here, we investigated the in vitro effect of LP on human sperm motility, viability, nitric oxide (NO) production, and the ability of LP to chelate seminal calcium. Seventy-two semen samples from normozoospermic men were tested in this study. The effects of LP at 0.375, 0.75, 1.5, and 3 μg/mL on sperm motility and viability as well as at 3 μg/mL on NO production and calcium chelation in semen were assessed. Lansoprazole at 3 μg/mL significantly decreased total and progressive sperm motility (P = 0.0021, P = 0.0256, respectively), but not sperm viability (P = 0.8763). In addition, semen samples supplemented with 3 μg/mL LP had insignificant changes (P = 0.9085) in nitrite concentrations. Moreover, LP exhibited a significant (P < 0.0001) calcium chelation effect in semen. In conclusion, LP reduced sperm motility, but not viability. The reduction in sperm motility may be due to the calcium chelating effect of LP and/or decreased Na+/K+-ATPase activity, but not an alteration in NO production. Besides, none of the tested parameters was found to be correlated with male age. |
| first_indexed | 2024-12-19T10:34:35Z |
| format | Article |
| id | doaj.art-8f588748179246eaa31f627d01353fbf |
| institution | Directory Open Access Journal |
| issn | 1735-5362 1735-9414 |
| language | English |
| last_indexed | 2024-12-19T10:34:35Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Research in Pharmaceutical Sciences |
| spelling | doaj.art-8f588748179246eaa31f627d01353fbf2022-12-21T20:25:39ZengWolters Kluwer Medknow PublicationsResearch in Pharmaceutical Sciences1735-53621735-94142018-01-0113546046810.4103/1735-5362.236839Effect of lansoprazole on human sperm motility, sperm viability, seminal nitric oxide production, and seminal calcium chelationSaleem Ali BanihaniFalak Hisham KhasawnehLansoprazole is a proton-pump inhibitor that is commonly used to treat many gastric illnesses. However, little is known about its effect on sperm function. Here, we investigated the in vitro effect of LP on human sperm motility, viability, nitric oxide (NO) production, and the ability of LP to chelate seminal calcium. Seventy-two semen samples from normozoospermic men were tested in this study. The effects of LP at 0.375, 0.75, 1.5, and 3 μg/mL on sperm motility and viability as well as at 3 μg/mL on NO production and calcium chelation in semen were assessed. Lansoprazole at 3 μg/mL significantly decreased total and progressive sperm motility (P = 0.0021, P = 0.0256, respectively), but not sperm viability (P = 0.8763). In addition, semen samples supplemented with 3 μg/mL LP had insignificant changes (P = 0.9085) in nitrite concentrations. Moreover, LP exhibited a significant (P < 0.0001) calcium chelation effect in semen. In conclusion, LP reduced sperm motility, but not viability. The reduction in sperm motility may be due to the calcium chelating effect of LP and/or decreased Na+/K+-ATPase activity, but not an alteration in NO production. Besides, none of the tested parameters was found to be correlated with male age.http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2018;volume=13;issue=5;spage=460;epage=468;aulast=Banihanihuman semen; lansoprazole; nitric oxide; sperm motility; sperm viability |
| spellingShingle | Saleem Ali Banihani Falak Hisham Khasawneh Effect of lansoprazole on human sperm motility, sperm viability, seminal nitric oxide production, and seminal calcium chelation Research in Pharmaceutical Sciences human semen; lansoprazole; nitric oxide; sperm motility; sperm viability |
| title | Effect of lansoprazole on human sperm motility, sperm viability, seminal nitric oxide production, and seminal calcium chelation |
| title_full | Effect of lansoprazole on human sperm motility, sperm viability, seminal nitric oxide production, and seminal calcium chelation |
| title_fullStr | Effect of lansoprazole on human sperm motility, sperm viability, seminal nitric oxide production, and seminal calcium chelation |
| title_full_unstemmed | Effect of lansoprazole on human sperm motility, sperm viability, seminal nitric oxide production, and seminal calcium chelation |
| title_short | Effect of lansoprazole on human sperm motility, sperm viability, seminal nitric oxide production, and seminal calcium chelation |
| title_sort | effect of lansoprazole on human sperm motility sperm viability seminal nitric oxide production and seminal calcium chelation |
| topic | human semen; lansoprazole; nitric oxide; sperm motility; sperm viability |
| url | http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2018;volume=13;issue=5;spage=460;epage=468;aulast=Banihani |
| work_keys_str_mv | AT saleemalibanihani effectoflansoprazoleonhumanspermmotilityspermviabilityseminalnitricoxideproductionandseminalcalciumchelation AT falakhishamkhasawneh effectoflansoprazoleonhumanspermmotilityspermviabilityseminalnitricoxideproductionandseminalcalciumchelation |