Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems
Abstract Over the last decade, scientists have dreamed about the development of a bioresorbable technology that exploits a new class of electrical, optical, and sensing components able to operate in physiological conditions for a prescribed time and then disappear, being made of materials that fully...
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| Format: | Article |
| Language: | English |
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Wiley
2020-02-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.201902872 |
| _version_ | 1811215059109543936 |
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| author | Antonino A. La Mattina Stefano Mariani Giuseppe Barillaro |
| author_facet | Antonino A. La Mattina Stefano Mariani Giuseppe Barillaro |
| author_sort | Antonino A. La Mattina |
| collection | DOAJ |
| description | Abstract Over the last decade, scientists have dreamed about the development of a bioresorbable technology that exploits a new class of electrical, optical, and sensing components able to operate in physiological conditions for a prescribed time and then disappear, being made of materials that fully dissolve in vivo with biologically benign byproducts upon external stimulation. The final goal is to engineer these components into transient implantable systems that directly interact with organs, tissues, and biofluids in real‐time, retrieve clinical parameters, and provide therapeutic actions tailored to the disease and patient clinical evolution, and then biodegrade without the need for device‐retrieving surgery that may cause tissue lesion or infection. Here, the major results achieved in bioresorbable technology are critically reviewed, with a bottom‐up approach that starts from a rational analysis of dissolution chemistry and kinetics, and biocompatibility of bioresorbable materials, then moves to in vivo performance and stability of electrical and optical bioresorbable components, and eventually focuses on the integration of such components into bioresorbable systems for clinically relevant applications. Finally, the technology readiness levels (TRLs) achieved for the different bioresorbable devices and systems are assessed, hence the open challenges are analyzed and future directions for advancing the technology are envisaged. |
| first_indexed | 2024-04-12T06:15:04Z |
| format | Article |
| id | doaj.art-8f589ae30e3c45f0a5d5524144bd8438 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-12T06:15:04Z |
| publishDate | 2020-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-8f589ae30e3c45f0a5d5524144bd84382022-12-22T03:44:31ZengWileyAdvanced Science2198-38442020-02-0174n/an/a10.1002/advs.201902872Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring SystemsAntonino A. La Mattina0Stefano Mariani1Giuseppe Barillaro2Dipartimento di Ingegneria dell'Informazione Università di Pisa Via G. Caruso 16 56122 Pisa ItalyDipartimento di Ingegneria dell'Informazione Università di Pisa Via G. Caruso 16 56122 Pisa ItalyDipartimento di Ingegneria dell'Informazione Università di Pisa Via G. Caruso 16 56122 Pisa ItalyAbstract Over the last decade, scientists have dreamed about the development of a bioresorbable technology that exploits a new class of electrical, optical, and sensing components able to operate in physiological conditions for a prescribed time and then disappear, being made of materials that fully dissolve in vivo with biologically benign byproducts upon external stimulation. The final goal is to engineer these components into transient implantable systems that directly interact with organs, tissues, and biofluids in real‐time, retrieve clinical parameters, and provide therapeutic actions tailored to the disease and patient clinical evolution, and then biodegrade without the need for device‐retrieving surgery that may cause tissue lesion or infection. Here, the major results achieved in bioresorbable technology are critically reviewed, with a bottom‐up approach that starts from a rational analysis of dissolution chemistry and kinetics, and biocompatibility of bioresorbable materials, then moves to in vivo performance and stability of electrical and optical bioresorbable components, and eventually focuses on the integration of such components into bioresorbable systems for clinically relevant applications. Finally, the technology readiness levels (TRLs) achieved for the different bioresorbable devices and systems are assessed, hence the open challenges are analyzed and future directions for advancing the technology are envisaged.https://doi.org/10.1002/advs.201902872biodegradable sensorsbioresorbable materialsimplanted devicesmaterial dissolutiontransient electronics |
| spellingShingle | Antonino A. La Mattina Stefano Mariani Giuseppe Barillaro Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems Advanced Science biodegradable sensors bioresorbable materials implanted devices material dissolution transient electronics |
| title | Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems |
| title_full | Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems |
| title_fullStr | Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems |
| title_full_unstemmed | Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems |
| title_short | Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems |
| title_sort | bioresorbable materials on the rise from electronic components and physical sensors to in vivo monitoring systems |
| topic | biodegradable sensors bioresorbable materials implanted devices material dissolution transient electronics |
| url | https://doi.org/10.1002/advs.201902872 |
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