Data on the transcriptional regulation of DNA damage induced apoptosis suppressor (DDIAS) by ERK5/MEF2B pathway in lung cancer cells
The data included in this article are associated with the article entitled “DNA-damage-induced apoptosis suppressor (DDIAS) is upregulated via ERK5/MEF2B signaling and promotes β-catenin-mediated invasion” (J.Y. Im, S.H. Yoon, B.K. Kim, H.S. Ban, K.J. Won, K.S. Chung, K.E. Jung, M. Won) [1]. Quantit...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-12-01
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| Series: | Data in Brief |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340916305674 |
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| author | Joo-Young Im Sung-Hoon Yoon Bo-Kyung Kim Hyun Seung Ban Kyoung-Jae Won Kyung-Sook Chung Kyeong Eun Jung Misun Won |
| author_facet | Joo-Young Im Sung-Hoon Yoon Bo-Kyung Kim Hyun Seung Ban Kyoung-Jae Won Kyung-Sook Chung Kyeong Eun Jung Misun Won |
| author_sort | Joo-Young Im |
| collection | DOAJ |
| description | The data included in this article are associated with the article entitled “DNA-damage-induced apoptosis suppressor (DDIAS) is upregulated via ERK5/MEF2B signaling and promotes β-catenin-mediated invasion” (J.Y. Im, S.H. Yoon, B.K. Kim, H.S. Ban, K.J. Won, K.S. Chung, K.E. Jung, M. Won) [1]. Quantitative RT-PCR data revealed that genetic or pharmacological inhibition of extracellular signal-regulated kinase 5 (ERK5) suppresses DDIAS transcription in response to epidermal growth factor (EGF) in Hela cells. p300 did not interact with myocyte enhancer factor 2B (MEF2B), a downstream target of ERK5 and affect transcription of DDIAS. Moreover, DDIAS transcription is activated by ERK5/MEF2B signaling on EGF exposure in the non-small cell lung cancer cells (NSCLC) NCI-H1703 and NCI-H1299. DDIAS knockdown suppresses lung cancer cell invasion by decreasing β-catenin protein level on EGF exposure. |
| first_indexed | 2024-12-23T20:18:43Z |
| format | Article |
| id | doaj.art-8f5a0921dc444bfc964f6f0c39e7c65d |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-23T20:18:43Z |
| publishDate | 2016-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-8f5a0921dc444bfc964f6f0c39e7c65d2022-12-21T17:32:36ZengElsevierData in Brief2352-34092016-12-019C25726110.1016/j.dib.2016.08.066Data on the transcriptional regulation of DNA damage induced apoptosis suppressor (DDIAS) by ERK5/MEF2B pathway in lung cancer cellsJoo-Young Im0Sung-Hoon Yoon1Bo-Kyung Kim2Hyun Seung Ban3Kyoung-Jae Won4Kyung-Sook Chung5Kyeong Eun Jung6Misun Won7Personalized Genomic Medicine Research Center, KRIBB, Daejeon 305-806, KoreaPersonalized Genomic Medicine Research Center, KRIBB, Daejeon 305-806, KoreaPersonalized Genomic Medicine Research Center, KRIBB, Daejeon 305-806, KoreaBiomedical Translational Research Center, KRIBB, Daejeon 305-806, KoreaPersonalized Genomic Medicine Research Center, KRIBB, Daejeon 305-806, KoreaBiomedical Translational Research Center, KRIBB, Daejeon 305-806, KoreaST Pharm. Co., LTD, Sihwa Industrial Complex 1, Kyunggido 429-848, KoreaPersonalized Genomic Medicine Research Center, KRIBB, Daejeon 305-806, KoreaThe data included in this article are associated with the article entitled “DNA-damage-induced apoptosis suppressor (DDIAS) is upregulated via ERK5/MEF2B signaling and promotes β-catenin-mediated invasion” (J.Y. Im, S.H. Yoon, B.K. Kim, H.S. Ban, K.J. Won, K.S. Chung, K.E. Jung, M. Won) [1]. Quantitative RT-PCR data revealed that genetic or pharmacological inhibition of extracellular signal-regulated kinase 5 (ERK5) suppresses DDIAS transcription in response to epidermal growth factor (EGF) in Hela cells. p300 did not interact with myocyte enhancer factor 2B (MEF2B), a downstream target of ERK5 and affect transcription of DDIAS. Moreover, DDIAS transcription is activated by ERK5/MEF2B signaling on EGF exposure in the non-small cell lung cancer cells (NSCLC) NCI-H1703 and NCI-H1299. DDIAS knockdown suppresses lung cancer cell invasion by decreasing β-catenin protein level on EGF exposure.http://www.sciencedirect.com/science/article/pii/S2352340916305674DDIASERK5MEF2BLung cancer |
| spellingShingle | Joo-Young Im Sung-Hoon Yoon Bo-Kyung Kim Hyun Seung Ban Kyoung-Jae Won Kyung-Sook Chung Kyeong Eun Jung Misun Won Data on the transcriptional regulation of DNA damage induced apoptosis suppressor (DDIAS) by ERK5/MEF2B pathway in lung cancer cells Data in Brief DDIAS ERK5 MEF2B Lung cancer |
| title | Data on the transcriptional regulation of DNA damage induced apoptosis suppressor (DDIAS) by ERK5/MEF2B pathway in lung cancer cells |
| title_full | Data on the transcriptional regulation of DNA damage induced apoptosis suppressor (DDIAS) by ERK5/MEF2B pathway in lung cancer cells |
| title_fullStr | Data on the transcriptional regulation of DNA damage induced apoptosis suppressor (DDIAS) by ERK5/MEF2B pathway in lung cancer cells |
| title_full_unstemmed | Data on the transcriptional regulation of DNA damage induced apoptosis suppressor (DDIAS) by ERK5/MEF2B pathway in lung cancer cells |
| title_short | Data on the transcriptional regulation of DNA damage induced apoptosis suppressor (DDIAS) by ERK5/MEF2B pathway in lung cancer cells |
| title_sort | data on the transcriptional regulation of dna damage induced apoptosis suppressor ddias by erk5 mef2b pathway in lung cancer cells |
| topic | DDIAS ERK5 MEF2B Lung cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2352340916305674 |
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