Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action
Colorectal cancer (CRC) is the third most common malignant tumor in the world, and it is prone to recurrence and metastasis during treatment. Aerobic glycolysis is one of the main characteristics of tumor cell metabolism in CRC. Tumor cells rely on glycolysis to rapidly consume glucose and to obtain...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1257450/full |
| _version_ | 1827860837623136256 |
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| author | Lu Zhan Fangting Su Qiang Li Yueqiang Wen Feng Wei Zhelin He Xiaoyan Chen Xiang Yin Jian Wang Yilin Cai Yuxia Gong Yu Chen Xiao Ma Jinhao Zeng Jinhao Zeng |
| author_facet | Lu Zhan Fangting Su Qiang Li Yueqiang Wen Feng Wei Zhelin He Xiaoyan Chen Xiang Yin Jian Wang Yilin Cai Yuxia Gong Yu Chen Xiao Ma Jinhao Zeng Jinhao Zeng |
| author_sort | Lu Zhan |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is the third most common malignant tumor in the world, and it is prone to recurrence and metastasis during treatment. Aerobic glycolysis is one of the main characteristics of tumor cell metabolism in CRC. Tumor cells rely on glycolysis to rapidly consume glucose and to obtain more lactate and intermediate macromolecular products so as to maintain growth and proliferation. The regulation of the CRC glycolysis pathway is closely associated with several signal transduction pathways and transcription factors including phosphatidylinositol 3-kinases/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR), adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK), hypoxia-inducible factor-1 (HIF-1), myc, and p53. Targeting the glycolytic pathway has become one of the key research aspects in CRC therapy. Many phytochemicals were shown to exert anti-CRC activity by targeting the glycolytic pathway. Here, we review the effects and mechanisms of phytochemicals on CRC glycolytic pathways, providing a new method of drug development. |
| first_indexed | 2024-03-12T13:28:36Z |
| format | Article |
| id | doaj.art-8f5a7bf7079e45faa29c4c576b92d7f4 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-12T13:28:36Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-8f5a7bf7079e45faa29c4c576b92d7f42023-08-24T23:09:58ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-08-011410.3389/fphar.2023.12574501257450Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of actionLu Zhan0Fangting Su1Qiang Li2Yueqiang Wen3Feng Wei4Zhelin He5Xiaoyan Chen6Xiang Yin7Jian Wang8Yilin Cai9Yuxia Gong10Yu Chen11Xiao Ma12Jinhao Zeng13Jinhao Zeng14Department of Oncology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Oncology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Oncology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Oncology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaGuang’an Hospital of Traditional Chinese Medicine, Guang’an, ChinaGuang’an Hospital of Traditional Chinese Medicine, Guang’an, ChinaGuang’an Hospital of Traditional Chinese Medicine, Guang’an, ChinaGuang’an Hospital of Traditional Chinese Medicine, Guang’an, ChinaDepartment of Oncology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Oncology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Oncology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Gastroenterology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaColorectal cancer (CRC) is the third most common malignant tumor in the world, and it is prone to recurrence and metastasis during treatment. Aerobic glycolysis is one of the main characteristics of tumor cell metabolism in CRC. Tumor cells rely on glycolysis to rapidly consume glucose and to obtain more lactate and intermediate macromolecular products so as to maintain growth and proliferation. The regulation of the CRC glycolysis pathway is closely associated with several signal transduction pathways and transcription factors including phosphatidylinositol 3-kinases/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR), adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK), hypoxia-inducible factor-1 (HIF-1), myc, and p53. Targeting the glycolytic pathway has become one of the key research aspects in CRC therapy. Many phytochemicals were shown to exert anti-CRC activity by targeting the glycolytic pathway. Here, we review the effects and mechanisms of phytochemicals on CRC glycolytic pathways, providing a new method of drug development.https://www.frontiersin.org/articles/10.3389/fphar.2023.1257450/fullcolorectal cancerwarburg effectglycolysisphytochemicalsmolecular pathways |
| spellingShingle | Lu Zhan Fangting Su Qiang Li Yueqiang Wen Feng Wei Zhelin He Xiaoyan Chen Xiang Yin Jian Wang Yilin Cai Yuxia Gong Yu Chen Xiao Ma Jinhao Zeng Jinhao Zeng Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action Frontiers in Pharmacology colorectal cancer warburg effect glycolysis phytochemicals molecular pathways |
| title | Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action |
| title_full | Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action |
| title_fullStr | Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action |
| title_full_unstemmed | Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action |
| title_short | Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action |
| title_sort | phytochemicals targeting glycolysis in colorectal cancer therapy effects and mechanisms of action |
| topic | colorectal cancer warburg effect glycolysis phytochemicals molecular pathways |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1257450/full |
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