Assessment of psychiatric comorbidities and serotonergic or noradrenergic medication use on blood pressure using 24‐hour ambulatory blood pressure monitoring
Abstract In this study, the authors aimed to assess both nighttime and daytime blood pressure (BP) variability using 24‐hour ambulatory BP monitoring (ABPM) in persons with and without psychiatric conditions and with or without selective serotonin reuptake inhibitors (SSRIs) or serotonin‐norepinephr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-08-01
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| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.14311 |
| _version_ | 1797645172495876096 |
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| author | Shehzad K. Niazi Sobia H. Memon Elizabeth R. Lesser Emily Brennan Nabeel Aslam |
| author_facet | Shehzad K. Niazi Sobia H. Memon Elizabeth R. Lesser Emily Brennan Nabeel Aslam |
| author_sort | Shehzad K. Niazi |
| collection | DOAJ |
| description | Abstract In this study, the authors aimed to assess both nighttime and daytime blood pressure (BP) variability using 24‐hour ambulatory BP monitoring (ABPM) in persons with and without psychiatric conditions and with or without selective serotonin reuptake inhibitors (SSRIs) or serotonin‐norepinephrine reuptake inhibitors (SNRIs) treatment. In this retrospective study, patients who underwent psychiatric evaluation and ABPM within 6 months of each other between January 1, 2012 and December 31, 2017 were identified using billing data. Participants were divided into three groups—participants with no psychiatric diagnosis and no psychiatric medicine (−Diagnosis/−Medication), those with psychiatric diagnosis and on SSRIs/SNRIs (+Diagnosis/+Medication), and psychiatric diagnosis but no psychiatric medications (+Diagnosis/−Medication). Day and nighttime systolic and diastolic BPs were compared between groups controlling for relevant variables using multivariable linear regression models. A total of 475 participants met inclusion criteria including 135 in the −Diagnosis/−Medication group, 232 in the +Diagnosis/+Medication group, and 108 in the +Diagnosis/−Medication group. In adjusted multivariable analysis, the +Diagnosis/+Medication group had higher nighttime systolic BP (median 120 vs 110 mm (Hg); p = .01) and nighttime diastolic BP (median 68 vs 63 mm (Hg); p = .006) as compared to −Diagnosis/−Medication. No statistically significant differences in BPs between the −Diagnosis/−Medication and +Diagnosis/−Medication groups were observed, after adjustment. Use of SSRIs/SNRIs was associated with significantly higher nocturnal systolic and diastolic BP among patients with psychiatric diagnosis using SSRIs/SNRIs but not associated with psychiatric diagnosis without SSRI/SNRI use. SSRIs/SNRIs use may be associated with higher BP levels and this merits future prospective studies using ABPM to assess day and nighttime BP changes with SSRIs/SNRIs use. |
| first_indexed | 2024-03-11T14:43:31Z |
| format | Article |
| id | doaj.art-8f5c171633ca4d47938332ef3dc12381 |
| institution | Directory Open Access Journal |
| issn | 1524-6175 1751-7176 |
| language | English |
| last_indexed | 2024-03-11T14:43:31Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj.art-8f5c171633ca4d47938332ef3dc123812023-10-30T13:26:33ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762021-08-012381599160710.1111/jch.14311Assessment of psychiatric comorbidities and serotonergic or noradrenergic medication use on blood pressure using 24‐hour ambulatory blood pressure monitoringShehzad K. Niazi0Sobia H. Memon1Elizabeth R. Lesser2Emily Brennan3Nabeel Aslam4Department of Psychiatry & Psychology Mayo Clinic Florida Jacksonville Florida USADepartment of Medicine Division of Nephrology & Hypertension Mayo Clinic Florida Jacksonville Florida USADepartment of Biostatistics Health Science Research Mayo Clinic Florida Jacksonville Florida USAMayo Clinic Robert D. & Patricia E. Kern Center of Science of Health Care Delivery Jacksonville Florida USADepartment of Medicine Division of Nephrology & Hypertension Mayo Clinic Florida Jacksonville Florida USAAbstract In this study, the authors aimed to assess both nighttime and daytime blood pressure (BP) variability using 24‐hour ambulatory BP monitoring (ABPM) in persons with and without psychiatric conditions and with or without selective serotonin reuptake inhibitors (SSRIs) or serotonin‐norepinephrine reuptake inhibitors (SNRIs) treatment. In this retrospective study, patients who underwent psychiatric evaluation and ABPM within 6 months of each other between January 1, 2012 and December 31, 2017 were identified using billing data. Participants were divided into three groups—participants with no psychiatric diagnosis and no psychiatric medicine (−Diagnosis/−Medication), those with psychiatric diagnosis and on SSRIs/SNRIs (+Diagnosis/+Medication), and psychiatric diagnosis but no psychiatric medications (+Diagnosis/−Medication). Day and nighttime systolic and diastolic BPs were compared between groups controlling for relevant variables using multivariable linear regression models. A total of 475 participants met inclusion criteria including 135 in the −Diagnosis/−Medication group, 232 in the +Diagnosis/+Medication group, and 108 in the +Diagnosis/−Medication group. In adjusted multivariable analysis, the +Diagnosis/+Medication group had higher nighttime systolic BP (median 120 vs 110 mm (Hg); p = .01) and nighttime diastolic BP (median 68 vs 63 mm (Hg); p = .006) as compared to −Diagnosis/−Medication. No statistically significant differences in BPs between the −Diagnosis/−Medication and +Diagnosis/−Medication groups were observed, after adjustment. Use of SSRIs/SNRIs was associated with significantly higher nocturnal systolic and diastolic BP among patients with psychiatric diagnosis using SSRIs/SNRIs but not associated with psychiatric diagnosis without SSRI/SNRI use. SSRIs/SNRIs use may be associated with higher BP levels and this merits future prospective studies using ABPM to assess day and nighttime BP changes with SSRIs/SNRIs use.https://doi.org/10.1111/jch.14311ambulatory blood pressure monitoringhypertensionpsychiatric diagnosisselective serotonin reuptake inhibitorsserotonin‐norepinephrine reuptake inhibitors |
| spellingShingle | Shehzad K. Niazi Sobia H. Memon Elizabeth R. Lesser Emily Brennan Nabeel Aslam Assessment of psychiatric comorbidities and serotonergic or noradrenergic medication use on blood pressure using 24‐hour ambulatory blood pressure monitoring The Journal of Clinical Hypertension ambulatory blood pressure monitoring hypertension psychiatric diagnosis selective serotonin reuptake inhibitors serotonin‐norepinephrine reuptake inhibitors |
| title | Assessment of psychiatric comorbidities and serotonergic or noradrenergic medication use on blood pressure using 24‐hour ambulatory blood pressure monitoring |
| title_full | Assessment of psychiatric comorbidities and serotonergic or noradrenergic medication use on blood pressure using 24‐hour ambulatory blood pressure monitoring |
| title_fullStr | Assessment of psychiatric comorbidities and serotonergic or noradrenergic medication use on blood pressure using 24‐hour ambulatory blood pressure monitoring |
| title_full_unstemmed | Assessment of psychiatric comorbidities and serotonergic or noradrenergic medication use on blood pressure using 24‐hour ambulatory blood pressure monitoring |
| title_short | Assessment of psychiatric comorbidities and serotonergic or noradrenergic medication use on blood pressure using 24‐hour ambulatory blood pressure monitoring |
| title_sort | assessment of psychiatric comorbidities and serotonergic or noradrenergic medication use on blood pressure using 24 hour ambulatory blood pressure monitoring |
| topic | ambulatory blood pressure monitoring hypertension psychiatric diagnosis selective serotonin reuptake inhibitors serotonin‐norepinephrine reuptake inhibitors |
| url | https://doi.org/10.1111/jch.14311 |
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