Current Status of and Future Prospects for Drug-Eluting Stents and Scaffolds in Infrapopliteal Arteries

<b>Background:</b> Chronic limb-threatening ischaemia can be a debilitating disease and may result in limb amputation if untreated. Atherosclerotic disease of the infra-popliteal arteries is particularly challenging to treat due to the small caliber of the vessels and the heavy burden of...

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Main Authors: Elizabeth Lim, Ramon L. Varcoe
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Journal of Clinical Medicine
Subjects:
Online Access:https://www.mdpi.com/2077-0383/13/6/1757
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author Elizabeth Lim
Ramon L. Varcoe
author_facet Elizabeth Lim
Ramon L. Varcoe
author_sort Elizabeth Lim
collection DOAJ
description <b>Background:</b> Chronic limb-threatening ischaemia can be a debilitating disease and may result in limb amputation if untreated. Atherosclerotic disease of the infra-popliteal arteries is particularly challenging to treat due to the small caliber of the vessels and the heavy burden of atherosclerotic plaque. Percutaneous transluminal angioplasty is the conventional first-line approach and is advantageous due to its minimal invasiveness, repeatability, and cost-effectiveness but is limited by high rates of elastic recoil, dissection, and short- to mid-term re-stenosis. <b>Methods:</b> This review analyses the growing body of published and presented clinical data from multiple randomised controlled trials that have investigated the role of coronary drug-eluting stents in the treatment of infrapopliteal disease. <b>Results:</b> Coronary drug-eluting stents demonstrate superior primary patency compared with angioplasty and/or bare metal stenting alone but are limited to application in short-segment disease and have not been widely adopted due to the nature of the permanent implant. <b>Conclusions:</b> Newer devices like drug-eluting resorbable scaffolds are promising as they allow the restoration of vessel wall vasomotion without a residual foreign body and can be used to treat longer, complex lesions.
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spelling doaj.art-8f5e341a627949d2b65191b59062e2ba2024-03-27T13:48:14ZengMDPI AGJournal of Clinical Medicine2077-03832024-03-01136175710.3390/jcm13061757Current Status of and Future Prospects for Drug-Eluting Stents and Scaffolds in Infrapopliteal ArteriesElizabeth Lim0Ramon L. Varcoe1The Prince of Wales Hospital, Sydney, NSW 2031, AustraliaThe Prince of Wales Hospital, University of New South Wales, Sydney, NSW 2031, Australia<b>Background:</b> Chronic limb-threatening ischaemia can be a debilitating disease and may result in limb amputation if untreated. Atherosclerotic disease of the infra-popliteal arteries is particularly challenging to treat due to the small caliber of the vessels and the heavy burden of atherosclerotic plaque. Percutaneous transluminal angioplasty is the conventional first-line approach and is advantageous due to its minimal invasiveness, repeatability, and cost-effectiveness but is limited by high rates of elastic recoil, dissection, and short- to mid-term re-stenosis. <b>Methods:</b> This review analyses the growing body of published and presented clinical data from multiple randomised controlled trials that have investigated the role of coronary drug-eluting stents in the treatment of infrapopliteal disease. <b>Results:</b> Coronary drug-eluting stents demonstrate superior primary patency compared with angioplasty and/or bare metal stenting alone but are limited to application in short-segment disease and have not been widely adopted due to the nature of the permanent implant. <b>Conclusions:</b> Newer devices like drug-eluting resorbable scaffolds are promising as they allow the restoration of vessel wall vasomotion without a residual foreign body and can be used to treat longer, complex lesions.https://www.mdpi.com/2077-0383/13/6/1757critical limb-threatening ischaemiadrug-eluting stentsendovascularbioresorbable scaffold
spellingShingle Elizabeth Lim
Ramon L. Varcoe
Current Status of and Future Prospects for Drug-Eluting Stents and Scaffolds in Infrapopliteal Arteries
Journal of Clinical Medicine
critical limb-threatening ischaemia
drug-eluting stents
endovascular
bioresorbable scaffold
title Current Status of and Future Prospects for Drug-Eluting Stents and Scaffolds in Infrapopliteal Arteries
title_full Current Status of and Future Prospects for Drug-Eluting Stents and Scaffolds in Infrapopliteal Arteries
title_fullStr Current Status of and Future Prospects for Drug-Eluting Stents and Scaffolds in Infrapopliteal Arteries
title_full_unstemmed Current Status of and Future Prospects for Drug-Eluting Stents and Scaffolds in Infrapopliteal Arteries
title_short Current Status of and Future Prospects for Drug-Eluting Stents and Scaffolds in Infrapopliteal Arteries
title_sort current status of and future prospects for drug eluting stents and scaffolds in infrapopliteal arteries
topic critical limb-threatening ischaemia
drug-eluting stents
endovascular
bioresorbable scaffold
url https://www.mdpi.com/2077-0383/13/6/1757
work_keys_str_mv AT elizabethlim currentstatusofandfutureprospectsfordrugelutingstentsandscaffoldsininfrapoplitealarteries
AT ramonlvarcoe currentstatusofandfutureprospectsfordrugelutingstentsandscaffoldsininfrapoplitealarteries