Current Status of and Future Prospects for Drug-Eluting Stents and Scaffolds in Infrapopliteal Arteries
<b>Background:</b> Chronic limb-threatening ischaemia can be a debilitating disease and may result in limb amputation if untreated. Atherosclerotic disease of the infra-popliteal arteries is particularly challenging to treat due to the small caliber of the vessels and the heavy burden of...
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MDPI AG
2024-03-01
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Series: | Journal of Clinical Medicine |
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Online Access: | https://www.mdpi.com/2077-0383/13/6/1757 |
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author | Elizabeth Lim Ramon L. Varcoe |
author_facet | Elizabeth Lim Ramon L. Varcoe |
author_sort | Elizabeth Lim |
collection | DOAJ |
description | <b>Background:</b> Chronic limb-threatening ischaemia can be a debilitating disease and may result in limb amputation if untreated. Atherosclerotic disease of the infra-popliteal arteries is particularly challenging to treat due to the small caliber of the vessels and the heavy burden of atherosclerotic plaque. Percutaneous transluminal angioplasty is the conventional first-line approach and is advantageous due to its minimal invasiveness, repeatability, and cost-effectiveness but is limited by high rates of elastic recoil, dissection, and short- to mid-term re-stenosis. <b>Methods:</b> This review analyses the growing body of published and presented clinical data from multiple randomised controlled trials that have investigated the role of coronary drug-eluting stents in the treatment of infrapopliteal disease. <b>Results:</b> Coronary drug-eluting stents demonstrate superior primary patency compared with angioplasty and/or bare metal stenting alone but are limited to application in short-segment disease and have not been widely adopted due to the nature of the permanent implant. <b>Conclusions:</b> Newer devices like drug-eluting resorbable scaffolds are promising as they allow the restoration of vessel wall vasomotion without a residual foreign body and can be used to treat longer, complex lesions. |
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language | English |
last_indexed | 2024-04-24T18:08:15Z |
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spelling | doaj.art-8f5e341a627949d2b65191b59062e2ba2024-03-27T13:48:14ZengMDPI AGJournal of Clinical Medicine2077-03832024-03-01136175710.3390/jcm13061757Current Status of and Future Prospects for Drug-Eluting Stents and Scaffolds in Infrapopliteal ArteriesElizabeth Lim0Ramon L. Varcoe1The Prince of Wales Hospital, Sydney, NSW 2031, AustraliaThe Prince of Wales Hospital, University of New South Wales, Sydney, NSW 2031, Australia<b>Background:</b> Chronic limb-threatening ischaemia can be a debilitating disease and may result in limb amputation if untreated. Atherosclerotic disease of the infra-popliteal arteries is particularly challenging to treat due to the small caliber of the vessels and the heavy burden of atherosclerotic plaque. Percutaneous transluminal angioplasty is the conventional first-line approach and is advantageous due to its minimal invasiveness, repeatability, and cost-effectiveness but is limited by high rates of elastic recoil, dissection, and short- to mid-term re-stenosis. <b>Methods:</b> This review analyses the growing body of published and presented clinical data from multiple randomised controlled trials that have investigated the role of coronary drug-eluting stents in the treatment of infrapopliteal disease. <b>Results:</b> Coronary drug-eluting stents demonstrate superior primary patency compared with angioplasty and/or bare metal stenting alone but are limited to application in short-segment disease and have not been widely adopted due to the nature of the permanent implant. <b>Conclusions:</b> Newer devices like drug-eluting resorbable scaffolds are promising as they allow the restoration of vessel wall vasomotion without a residual foreign body and can be used to treat longer, complex lesions.https://www.mdpi.com/2077-0383/13/6/1757critical limb-threatening ischaemiadrug-eluting stentsendovascularbioresorbable scaffold |
spellingShingle | Elizabeth Lim Ramon L. Varcoe Current Status of and Future Prospects for Drug-Eluting Stents and Scaffolds in Infrapopliteal Arteries Journal of Clinical Medicine critical limb-threatening ischaemia drug-eluting stents endovascular bioresorbable scaffold |
title | Current Status of and Future Prospects for Drug-Eluting Stents and Scaffolds in Infrapopliteal Arteries |
title_full | Current Status of and Future Prospects for Drug-Eluting Stents and Scaffolds in Infrapopliteal Arteries |
title_fullStr | Current Status of and Future Prospects for Drug-Eluting Stents and Scaffolds in Infrapopliteal Arteries |
title_full_unstemmed | Current Status of and Future Prospects for Drug-Eluting Stents and Scaffolds in Infrapopliteal Arteries |
title_short | Current Status of and Future Prospects for Drug-Eluting Stents and Scaffolds in Infrapopliteal Arteries |
title_sort | current status of and future prospects for drug eluting stents and scaffolds in infrapopliteal arteries |
topic | critical limb-threatening ischaemia drug-eluting stents endovascular bioresorbable scaffold |
url | https://www.mdpi.com/2077-0383/13/6/1757 |
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