Role of Neutrophils on the Ocular Surface
The ocular surface is a gateway that contacts the outside and receives stimulation from the outside. The corneal innate immune system is composed of many types of cells, including epithelial cells, fibroblasts, natural killer cells, macrophages, neutrophils, dendritic cells, mast cells, basophils, e...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/19/10386 |
| _version_ | 1797516350627774464 |
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| author | Yongseok Mun Jin Sun Hwang Young Joo Shin |
| author_facet | Yongseok Mun Jin Sun Hwang Young Joo Shin |
| author_sort | Yongseok Mun |
| collection | DOAJ |
| description | The ocular surface is a gateway that contacts the outside and receives stimulation from the outside. The corneal innate immune system is composed of many types of cells, including epithelial cells, fibroblasts, natural killer cells, macrophages, neutrophils, dendritic cells, mast cells, basophils, eosinophils, mucin, and lysozyme. Neutrophil infiltration and degranulation occur on the ocular surface. Degranulation, neutrophil extracellular traps formation, called NETosis, and autophagy in neutrophils are involved in the pathogenesis of ocular surface diseases. It is necessary to understand the role of neutrophils on the ocular surface. Furthermore, there is a need for research on therapeutic agents targeting neutrophils and neutrophil extracellular trap formation for ocular surface diseases. |
| first_indexed | 2024-03-10T07:00:01Z |
| format | Article |
| id | doaj.art-8f5fe684080d4ea885f0da004d75cf31 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T07:00:01Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8f5fe684080d4ea885f0da004d75cf312023-11-22T16:08:47ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-09-0122191038610.3390/ijms221910386Role of Neutrophils on the Ocular SurfaceYongseok Mun0Jin Sun Hwang1Young Joo Shin2Department of Ophthalmology, Hallym University Medical Center, Hallym University College of Medicine, Seoul 07442, KoreaDepartment of Ophthalmology, Hallym University Medical Center, Hallym University College of Medicine, Seoul 07442, KoreaDepartment of Ophthalmology, Hallym University Medical Center, Hallym University College of Medicine, Seoul 07442, KoreaThe ocular surface is a gateway that contacts the outside and receives stimulation from the outside. The corneal innate immune system is composed of many types of cells, including epithelial cells, fibroblasts, natural killer cells, macrophages, neutrophils, dendritic cells, mast cells, basophils, eosinophils, mucin, and lysozyme. Neutrophil infiltration and degranulation occur on the ocular surface. Degranulation, neutrophil extracellular traps formation, called NETosis, and autophagy in neutrophils are involved in the pathogenesis of ocular surface diseases. It is necessary to understand the role of neutrophils on the ocular surface. Furthermore, there is a need for research on therapeutic agents targeting neutrophils and neutrophil extracellular trap formation for ocular surface diseases.https://www.mdpi.com/1422-0067/22/19/10386ocular surface diseasedry eye syndromeneutrophilneutrophil extracellular trap |
| spellingShingle | Yongseok Mun Jin Sun Hwang Young Joo Shin Role of Neutrophils on the Ocular Surface International Journal of Molecular Sciences ocular surface disease dry eye syndrome neutrophil neutrophil extracellular trap |
| title | Role of Neutrophils on the Ocular Surface |
| title_full | Role of Neutrophils on the Ocular Surface |
| title_fullStr | Role of Neutrophils on the Ocular Surface |
| title_full_unstemmed | Role of Neutrophils on the Ocular Surface |
| title_short | Role of Neutrophils on the Ocular Surface |
| title_sort | role of neutrophils on the ocular surface |
| topic | ocular surface disease dry eye syndrome neutrophil neutrophil extracellular trap |
| url | https://www.mdpi.com/1422-0067/22/19/10386 |
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