The role of 18F-FDG PET/CT in patients with synchronous multiple primary malignant neoplasms occurring at the same time
BackgroundSynchronous multiple primary malignant neoplasms occurring at the same time (SMPMNS) are not currently uncommon in clinical oncological practice; however, the diagnostic performance of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for SMPMNS needs...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1068055/full |
| _version_ | 1828124930070282240 |
|---|---|
| author | Zhe Huang Luo Wan Ling Qi Ai Fang Jin Feng Xiang Liao Qian Liu Qing Yun Zeng |
| author_facet | Zhe Huang Luo Wan Ling Qi Ai Fang Jin Feng Xiang Liao Qian Liu Qing Yun Zeng |
| author_sort | Zhe Huang Luo |
| collection | DOAJ |
| description | BackgroundSynchronous multiple primary malignant neoplasms occurring at the same time (SMPMNS) are not currently uncommon in clinical oncological practice; however, the diagnostic performance of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for SMPMNS needs further elucidation.PurposeThis study aimed to evaluate the application of 18F-FDG PET/CT in patients with SMPMNS.Materials and methodsThe clinical and imaging data of 37 patients with SMPMNS who had undergone 18F-FDG PET/CT from October 2010 to December 2020 were retrospectively analyzed. The kappa consistency test was applied to evaluate the consistency of the diagnostic performance between PET/CT and conventional imaging (CI). The sensitivity, specificity, and accuracy of PET/CT and CI in the detection of metastatic lesions were compared.ResultsThis retrospective diagnostic study included 74 lesions identified in 37 patients with SMPMNS, with 94.6% of patients having double primary tumors. Of the incidences of SMPMNS, 18.9% occurred in the same organ system, with respiratory tumors being the most common type of neoplasm (43.2%) and the lung being the most common primary site (40.5%). The overall survival of SMPMNS patients without metastases was longer than that of those with metastases (χ2 = 12.627, p = 0.000). The maximum standardized uptake value (SUVmax), the SUVmax ratio (larger SUVmax/smaller SUVmax), and the difference index of SUVmax (DISUVmax) [(larger SUVmax − smaller SUVmax)/larger SUVmax] of the primary lesions ranged from 0.9 to 41.7 (average = 12.3 ± 7.9), from 0.3 to 26.7 (average = 4.4 ± 6.9), and from 0.0% to 96.3% (average = 50.3% ± 29.3%), respectively. With regard to diagnostic accuracy, PET/CT and CI showed poor consistency (κ = 0.096, p = 0.173). For the diagnosis of primary lesions (diagnosed and misdiagnosed), PET/CT and CI also showed poor consistency (κ = 0.277, p = 0.000), but the diagnostic performance of PET/CT was better than that of CI. In the diagnosis of metastases, the patient-based sensitivity, specificity, and accuracy of PET/CT were 100.0%, 81.8%, and 89.2%, respectively, while those of CI were 73.3%, 100.0%, 89.2%, respectively. The sensitivity and specificity values were significantly different, with PET/CT having higher sensitivity (p = 0.02) and CI showing higher specificity (p = 0.02).Conclusions18F-FDG PET/CT improves the diagnostic performance for SMPMNS and is a good imaging modality for patients with SMPMNS. |
| first_indexed | 2024-04-11T15:11:53Z |
| format | Article |
| id | doaj.art-8f6235111b394bb48ca4ad6bf87de389 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T15:11:53Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-8f6235111b394bb48ca4ad6bf87de3892022-12-22T04:16:36ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-12-011210.3389/fonc.2022.10680551068055The role of 18F-FDG PET/CT in patients with synchronous multiple primary malignant neoplasms occurring at the same timeZhe Huang Luo0Wan Ling Qi1Ai Fang Jin2Feng Xiang Liao3Qian Liu4Qing Yun Zeng5Department of Nuclear Medicine, Jiangxi Provincial People’s Hospital (The First Affiliated Hospital of Nanchang Medical College), Nanchang, ChinaDepartment of Nuclear Medicine, Jiangxi Provincial People’s Hospital (The First Affiliated Hospital of Nanchang Medical College), Nanchang, ChinaDepartment of Nuclear Medicine, Jiangxi Provincial People’s Hospital (The First Affiliated Hospital of Nanchang Medical College), Nanchang, ChinaDepartment of Nuclear Medicine, Jiangxi Provincial People’s Hospital (The First Affiliated Hospital of Nanchang Medical College), Nanchang, ChinaDepartment of Pathology, Jiangxi Provincial People’s Hospital (The First Affiliated Hospital of Nanchang Medical College), Nanchang, ChinaDepartment of Nuclear Medicine, Jiangxi Provincial People’s Hospital (The First Affiliated Hospital of Nanchang Medical College), Nanchang, ChinaBackgroundSynchronous multiple primary malignant neoplasms occurring at the same time (SMPMNS) are not currently uncommon in clinical oncological practice; however, the diagnostic performance of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for SMPMNS needs further elucidation.PurposeThis study aimed to evaluate the application of 18F-FDG PET/CT in patients with SMPMNS.Materials and methodsThe clinical and imaging data of 37 patients with SMPMNS who had undergone 18F-FDG PET/CT from October 2010 to December 2020 were retrospectively analyzed. The kappa consistency test was applied to evaluate the consistency of the diagnostic performance between PET/CT and conventional imaging (CI). The sensitivity, specificity, and accuracy of PET/CT and CI in the detection of metastatic lesions were compared.ResultsThis retrospective diagnostic study included 74 lesions identified in 37 patients with SMPMNS, with 94.6% of patients having double primary tumors. Of the incidences of SMPMNS, 18.9% occurred in the same organ system, with respiratory tumors being the most common type of neoplasm (43.2%) and the lung being the most common primary site (40.5%). The overall survival of SMPMNS patients without metastases was longer than that of those with metastases (χ2 = 12.627, p = 0.000). The maximum standardized uptake value (SUVmax), the SUVmax ratio (larger SUVmax/smaller SUVmax), and the difference index of SUVmax (DISUVmax) [(larger SUVmax − smaller SUVmax)/larger SUVmax] of the primary lesions ranged from 0.9 to 41.7 (average = 12.3 ± 7.9), from 0.3 to 26.7 (average = 4.4 ± 6.9), and from 0.0% to 96.3% (average = 50.3% ± 29.3%), respectively. With regard to diagnostic accuracy, PET/CT and CI showed poor consistency (κ = 0.096, p = 0.173). For the diagnosis of primary lesions (diagnosed and misdiagnosed), PET/CT and CI also showed poor consistency (κ = 0.277, p = 0.000), but the diagnostic performance of PET/CT was better than that of CI. In the diagnosis of metastases, the patient-based sensitivity, specificity, and accuracy of PET/CT were 100.0%, 81.8%, and 89.2%, respectively, while those of CI were 73.3%, 100.0%, 89.2%, respectively. The sensitivity and specificity values were significantly different, with PET/CT having higher sensitivity (p = 0.02) and CI showing higher specificity (p = 0.02).Conclusions18F-FDG PET/CT improves the diagnostic performance for SMPMNS and is a good imaging modality for patients with SMPMNS.https://www.frontiersin.org/articles/10.3389/fonc.2022.1068055/fullsynchronous multiple primary malignant neoplasmspositron emission tomography/computed tomography18F-fluorodeoxyglucose (18F-FDG)conventional imagingdiagnostic performance |
| spellingShingle | Zhe Huang Luo Wan Ling Qi Ai Fang Jin Feng Xiang Liao Qian Liu Qing Yun Zeng The role of 18F-FDG PET/CT in patients with synchronous multiple primary malignant neoplasms occurring at the same time Frontiers in Oncology synchronous multiple primary malignant neoplasms positron emission tomography/computed tomography 18F-fluorodeoxyglucose (18F-FDG) conventional imaging diagnostic performance |
| title | The role of 18F-FDG PET/CT in patients with synchronous multiple primary malignant neoplasms occurring at the same time |
| title_full | The role of 18F-FDG PET/CT in patients with synchronous multiple primary malignant neoplasms occurring at the same time |
| title_fullStr | The role of 18F-FDG PET/CT in patients with synchronous multiple primary malignant neoplasms occurring at the same time |
| title_full_unstemmed | The role of 18F-FDG PET/CT in patients with synchronous multiple primary malignant neoplasms occurring at the same time |
| title_short | The role of 18F-FDG PET/CT in patients with synchronous multiple primary malignant neoplasms occurring at the same time |
| title_sort | role of 18f fdg pet ct in patients with synchronous multiple primary malignant neoplasms occurring at the same time |
| topic | synchronous multiple primary malignant neoplasms positron emission tomography/computed tomography 18F-fluorodeoxyglucose (18F-FDG) conventional imaging diagnostic performance |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1068055/full |
| work_keys_str_mv | AT zhehuangluo theroleof18ffdgpetctinpatientswithsynchronousmultipleprimarymalignantneoplasmsoccurringatthesametime AT wanlingqi theroleof18ffdgpetctinpatientswithsynchronousmultipleprimarymalignantneoplasmsoccurringatthesametime AT aifangjin theroleof18ffdgpetctinpatientswithsynchronousmultipleprimarymalignantneoplasmsoccurringatthesametime AT fengxiangliao theroleof18ffdgpetctinpatientswithsynchronousmultipleprimarymalignantneoplasmsoccurringatthesametime AT qianliu theroleof18ffdgpetctinpatientswithsynchronousmultipleprimarymalignantneoplasmsoccurringatthesametime AT qingyunzeng theroleof18ffdgpetctinpatientswithsynchronousmultipleprimarymalignantneoplasmsoccurringatthesametime AT zhehuangluo roleof18ffdgpetctinpatientswithsynchronousmultipleprimarymalignantneoplasmsoccurringatthesametime AT wanlingqi roleof18ffdgpetctinpatientswithsynchronousmultipleprimarymalignantneoplasmsoccurringatthesametime AT aifangjin roleof18ffdgpetctinpatientswithsynchronousmultipleprimarymalignantneoplasmsoccurringatthesametime AT fengxiangliao roleof18ffdgpetctinpatientswithsynchronousmultipleprimarymalignantneoplasmsoccurringatthesametime AT qianliu roleof18ffdgpetctinpatientswithsynchronousmultipleprimarymalignantneoplasmsoccurringatthesametime AT qingyunzeng roleof18ffdgpetctinpatientswithsynchronousmultipleprimarymalignantneoplasmsoccurringatthesametime |