Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial
Abstract Objective: This study aims to evaluate the clinical and biochemical (oxidative stress and pro-inflammatory mediators) effects of the gaseous ozone use accompanied by scaling and root planning (SRP) in periodontal treatment. Material and Methods: The study population consisted of 40 patien...
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| Format: | Article |
| Language: | English |
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University of São Paulo
2019-01-01
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| Series: | Journal of Applied Oral Science |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572019000100428&lng=en&tlng=en |
| _version_ | 1818612205390659584 |
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| author | Eltas Seydanur Dengizek Dundar Serkan Eltas Abubekir Karabulut Aysun Bay Otlu Onder Cicek Arife |
| author_facet | Eltas Seydanur Dengizek Dundar Serkan Eltas Abubekir Karabulut Aysun Bay Otlu Onder Cicek Arife |
| author_sort | Eltas Seydanur Dengizek |
| collection | DOAJ |
| description | Abstract Objective: This study aims to evaluate the clinical and biochemical (oxidative stress and pro-inflammatory mediators) effects of the gaseous ozone use accompanied by scaling and root planning (SRP) in periodontal treatment. Material and Methods: The study population consisted of 40 patients with chronic periodontitis (CP) randomly sorted into two groups of 20. The experimental group received SRP plus 3 watts gaseous ozone in two separate applications five days apart, whereas the control group received SRP plus placebo. Clinical periodontal parameters were assayed and saliva samples were taken before the initial and one month after the second treatment. Periodontal examination assessed plaque index (PI), gingival index (GI), probing depth, and clinical attachment level (CAL). Total antioxidant status (TAS), total oxidant status (TOS), nitric oxide (NO), 8-hydroxy-2'-deoxyguanosine (8-OHdG), myeloperoxidase (MPO), glutathione (GSH), malondialdehyde (MDA), and transforming growth factor-beta (TGF-β) levels were evaluated from saliva samples. Results: Changes following treatment in PI, GI, probing depth, and CAL scores were similar for both groups (p>0.05). Of note, TGF-β levels were observed to be higher in the treatment group than in controls (p<0.05). Changes in 8-OHdG, TAS, TOS, NO, MPO, GSH and MDA levels, however, were not significantly different between groups (p>0.05). Conclusion: The findings of this study indicate that SRP plus gaseous ozone versus SRP alone does not correlate to a significant improvement in periodontal recovery. |
| first_indexed | 2024-12-16T15:42:31Z |
| format | Article |
| id | doaj.art-8f62a8c178d4430ca47206d98bfcd4b4 |
| institution | Directory Open Access Journal |
| issn | 1678-7765 |
| language | English |
| last_indexed | 2024-12-16T15:42:31Z |
| publishDate | 2019-01-01 |
| publisher | University of São Paulo |
| record_format | Article |
| series | Journal of Applied Oral Science |
| spelling | doaj.art-8f62a8c178d4430ca47206d98bfcd4b42022-12-21T22:25:57ZengUniversity of São PauloJournal of Applied Oral Science1678-77652019-01-0127010.1590/1678-7757-2018-0108S1678-77572019000100428Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trialEltas Seydanur DengizekDundar SerkanEltas AbubekirKarabulut Aysun BayOtlu OnderCicek ArifeAbstract Objective: This study aims to evaluate the clinical and biochemical (oxidative stress and pro-inflammatory mediators) effects of the gaseous ozone use accompanied by scaling and root planning (SRP) in periodontal treatment. Material and Methods: The study population consisted of 40 patients with chronic periodontitis (CP) randomly sorted into two groups of 20. The experimental group received SRP plus 3 watts gaseous ozone in two separate applications five days apart, whereas the control group received SRP plus placebo. Clinical periodontal parameters were assayed and saliva samples were taken before the initial and one month after the second treatment. Periodontal examination assessed plaque index (PI), gingival index (GI), probing depth, and clinical attachment level (CAL). Total antioxidant status (TAS), total oxidant status (TOS), nitric oxide (NO), 8-hydroxy-2'-deoxyguanosine (8-OHdG), myeloperoxidase (MPO), glutathione (GSH), malondialdehyde (MDA), and transforming growth factor-beta (TGF-β) levels were evaluated from saliva samples. Results: Changes following treatment in PI, GI, probing depth, and CAL scores were similar for both groups (p>0.05). Of note, TGF-β levels were observed to be higher in the treatment group than in controls (p<0.05). Changes in 8-OHdG, TAS, TOS, NO, MPO, GSH and MDA levels, however, were not significantly different between groups (p>0.05). Conclusion: The findings of this study indicate that SRP plus gaseous ozone versus SRP alone does not correlate to a significant improvement in periodontal recovery.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572019000100428&lng=en&tlng=enChronic periodontitisInflammationOzonePeriodontal treatmentTGF-β |
| spellingShingle | Eltas Seydanur Dengizek Dundar Serkan Eltas Abubekir Karabulut Aysun Bay Otlu Onder Cicek Arife Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial Journal of Applied Oral Science Chronic periodontitis Inflammation Ozone Periodontal treatment TGF-β |
| title | Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial |
| title_full | Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial |
| title_fullStr | Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial |
| title_full_unstemmed | Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial |
| title_short | Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial |
| title_sort | evaluating clinical and laboratory effects of ozone in non surgical periodontal treatment a randomized controlled trial |
| topic | Chronic periodontitis Inflammation Ozone Periodontal treatment TGF-β |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572019000100428&lng=en&tlng=en |
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