ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells

ZNF185 is identified as a novel PKA substrate and found to be important for the organization of endothelial cell–cell junctions and suppression of vascular hyperpermeability by regulating the cAMP/PKA/RhoA signaling pathway.

Bibliographic Details
Main Authors: Soichiro Suzuki, Fumiaki Ando, Sae Kitagawa, Yu Hara, Tamami Fujiki, Shintaro Mandai, Koichiro Susa, Takayasu Mori, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04416-x
Description
Summary:ZNF185 is identified as a novel PKA substrate and found to be important for the organization of endothelial cell–cell junctions and suppression of vascular hyperpermeability by regulating the cAMP/PKA/RhoA signaling pathway.
ISSN:2399-3642