<i>Bis</i>(Tryptophan) Amphiphiles Form Ion Conducting Pores and Enhance Antimicrobial Activity against Resistant Bacteria

<i>Bis</i>(Tryptophan) Amphiphiles Form Ion Conducting Pores and Enhance Antimicrobial Activity against Resistant Bacteria

The compounds referred to as <i>bis</i>(tryptophan)s (BTs) have shown activity as antimicrobials. The hypothesis that the activity of these novel amphiphiles results from insertion in bilayer membranes and transport of cations is supported by planar bilayer voltage-clamp studies reported...

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Bibliographic Details
Main Authors: Mohit Patel, Saeedeh Negin, Joseph Meisel, Shanheng Yin, Michael Gokel, Hannah Gill, George Gokel
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Antibiotics
Subjects:
adjuvant
amino acids
amphiphile
antimicrobial
bacteria
efflux pump
Online Access:https://www.mdpi.com/2079-6382/10/11/1391

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