Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts

Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts

Triple Negative Breast Cancer (TNBC) is aggressive, metastatic and drug-resistant, limiting the spectrum of effective therapeutic options for breast cancer patients. To date, anti-angiogenic agents have had limited success in the treatment of systemic breast cancer, possibly due to the exacerbation...

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Bibliographic Details
Main Authors:	Eva-Maria E. Hedlund, Paul C. McDonald, Oksana Nemirovsky, Shannon Awrey, Lasse D.E. Jensen, Shoukat Dedhar
Format:	Article
Language:	English
Published:	MDPI AG 2019-07-01
Series:	Cancers
Subjects:	angiogenesis carbonic anhydrase IX hypoxia metastasis resistance sunitinib triple negative breast cancer
Online Access:	https://www.mdpi.com/2072-6694/11/7/1002

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