3D Multicellular Stem-Like Human Breast Tumor Spheroids Enhance Tumorigenicity of Orthotopic Xenografts in Athymic Nude Rat Model

3D Multicellular Stem-Like Human Breast Tumor Spheroids Enhance Tumorigenicity of Orthotopic Xenografts in Athymic Nude Rat Model

Therapeutic targeting of stem cells needs to be strategically developed to control tumor growth and prevent metastatic burden successfully. Breast cancer presents a unique clinical problem because of the variety of cellular subtypes present, including cancer stem cells (CSCs). The development of 3D...

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Bibliographic Details
Main Authors: Reza Bayat Mokhtari, Bessi Qorri, Manpreet Sambi, Narges Baluch, Sushil Kumar, Bikul Das, Myron R. Szewczuk, Herman Yeger, Hai-Ling Margaret Cheng
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
multicellular 3D spheroid culture
orthotopic tumor xenograft
cancer stem cells
Online Access:https://www.mdpi.com/2072-6694/13/11/2784

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