Risk of thyroid cancer in a lung cancer screening population of the National Lung Screening Trial according to the presence of incidental thyroid nodules detected on low-dose chest CT
Purpose This study evaluated thyroid cancer risk in a lung cancer screening population according to the presence of an incidental thyroid nodule (ITN) detected on low-dose chest computed tomography (LDCT). Methods Of 47,837 subjects who underwent LDCT, a lung cancer screening population according to...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Ultrasound in Medicine
2023-04-01
|
| Series: | Ultrasonography |
| Subjects: | |
| Online Access: | http://www.e-ultrasonography.org/upload/usg-22111.pdf |
| _version_ | 1797853462962110464 |
|---|---|
| author | Hyobin Seo Kwang Nam Jin Ji Sang Park Koung Mi Kang Eun Kyung Lee Ji Ye Lee Roh-Eul Yoo Young Joo Park Ji-hoon Kim |
| author_facet | Hyobin Seo Kwang Nam Jin Ji Sang Park Koung Mi Kang Eun Kyung Lee Ji Ye Lee Roh-Eul Yoo Young Joo Park Ji-hoon Kim |
| author_sort | Hyobin Seo |
| collection | DOAJ |
| description | Purpose This study evaluated thyroid cancer risk in a lung cancer screening population according to the presence of an incidental thyroid nodule (ITN) detected on low-dose chest computed tomography (LDCT). Methods Of 47,837 subjects who underwent LDCT, a lung cancer screening population according to the National Lung Screening Trial results was retrospectively enrolled. The prevalence of ITN on LDCT was calculated, and the ultrasonography (US)/fine-needle aspiration (FNA)–based risk of thyroid cancer according to the presence of ITN on LDCT was compared using the Fisher exact or Student t-test as appropriate. Results Of the 2,329 subjects (female:male=44:2,285; mean age, 60.9±4.9 years), the prevalence of ITN on LDCT was 4.8% (111/2,329). The incidence of thyroid cancer was 0.8% (18/2,329, papillary thyroid microcarcinomas [PTMCs]) and was higher in the ITN-positive group than in the ITN-negative group (3.6% [4/111] vs. 0.6% [14/2,218], P=0.009). Among the 2,011 subjects who underwent both LDCT and thyroid US, all risks were higher (P<0.001) in the ITNpositive group than in the ITN-negative group: presence of thyroid nodule on US, 94.1% (95/101) vs. 48.6% (928/1,910); recommendation of FNA according to the American Thyroid Association guideline and Korean Thyroid Imaging Reporting and Data System guideline, 41.2% (42/101) vs. 2.4% (46/1,910) and 39.6% (40/101) vs. 1.9% (37/1,910), respectively. Conclusion Despite a higher risk of thyroid cancer in the LDCT ITN-positive group than in the ITN-negative group in a lung cancer screening population, all cancers were PTMCs. A heavy smoking history may not necessitate thorough screening US for thyroid incidentalomas. |
| first_indexed | 2024-04-09T19:51:01Z |
| format | Article |
| id | doaj.art-8f67f64a910b41e9b331e39596c64be7 |
| institution | Directory Open Access Journal |
| issn | 2288-5943 |
| language | English |
| last_indexed | 2024-04-09T19:51:01Z |
| publishDate | 2023-04-01 |
| publisher | Korean Society of Ultrasound in Medicine |
| record_format | Article |
| series | Ultrasonography |
| spelling | doaj.art-8f67f64a910b41e9b331e39596c64be72023-04-03T06:45:11ZengKorean Society of Ultrasound in MedicineUltrasonography2288-59432023-04-0142227528510.14366/usg.221111653Risk of thyroid cancer in a lung cancer screening population of the National Lung Screening Trial according to the presence of incidental thyroid nodules detected on low-dose chest CTHyobin Seo0Kwang Nam Jin1Ji Sang Park2Koung Mi Kang3Eun Kyung Lee4Ji Ye Lee5Roh-Eul Yoo6Young Joo Park7Ji-hoon Kim8 Department of Radiology, Human Medical Imaging & Intervention Center, Seoul, Korea Department of Radiology, SMG-SNU Boramae Medical Center, Seoul, Korea Department of Radiology, Konkuk University Chungju Hospital, Chungju, Korea Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea Department of Radiology, Gangnam Center, Seoul National University Hospital Healthcare System, Seoul, Korea Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, KoreaPurpose This study evaluated thyroid cancer risk in a lung cancer screening population according to the presence of an incidental thyroid nodule (ITN) detected on low-dose chest computed tomography (LDCT). Methods Of 47,837 subjects who underwent LDCT, a lung cancer screening population according to the National Lung Screening Trial results was retrospectively enrolled. The prevalence of ITN on LDCT was calculated, and the ultrasonography (US)/fine-needle aspiration (FNA)–based risk of thyroid cancer according to the presence of ITN on LDCT was compared using the Fisher exact or Student t-test as appropriate. Results Of the 2,329 subjects (female:male=44:2,285; mean age, 60.9±4.9 years), the prevalence of ITN on LDCT was 4.8% (111/2,329). The incidence of thyroid cancer was 0.8% (18/2,329, papillary thyroid microcarcinomas [PTMCs]) and was higher in the ITN-positive group than in the ITN-negative group (3.6% [4/111] vs. 0.6% [14/2,218], P=0.009). Among the 2,011 subjects who underwent both LDCT and thyroid US, all risks were higher (P<0.001) in the ITNpositive group than in the ITN-negative group: presence of thyroid nodule on US, 94.1% (95/101) vs. 48.6% (928/1,910); recommendation of FNA according to the American Thyroid Association guideline and Korean Thyroid Imaging Reporting and Data System guideline, 41.2% (42/101) vs. 2.4% (46/1,910) and 39.6% (40/101) vs. 1.9% (37/1,910), respectively. Conclusion Despite a higher risk of thyroid cancer in the LDCT ITN-positive group than in the ITN-negative group in a lung cancer screening population, all cancers were PTMCs. A heavy smoking history may not necessitate thorough screening US for thyroid incidentalomas.http://www.e-ultrasonography.org/upload/usg-22111.pdfthyroid neoplasmsnational lung screening trialincidental thyroid nodulelow-dose chest ctultrasound |
| spellingShingle | Hyobin Seo Kwang Nam Jin Ji Sang Park Koung Mi Kang Eun Kyung Lee Ji Ye Lee Roh-Eul Yoo Young Joo Park Ji-hoon Kim Risk of thyroid cancer in a lung cancer screening population of the National Lung Screening Trial according to the presence of incidental thyroid nodules detected on low-dose chest CT Ultrasonography thyroid neoplasms national lung screening trial incidental thyroid nodule low-dose chest ct ultrasound |
| title | Risk of thyroid cancer in a lung cancer screening population of the National Lung Screening Trial according to the presence of incidental thyroid nodules detected on low-dose chest CT |
| title_full | Risk of thyroid cancer in a lung cancer screening population of the National Lung Screening Trial according to the presence of incidental thyroid nodules detected on low-dose chest CT |
| title_fullStr | Risk of thyroid cancer in a lung cancer screening population of the National Lung Screening Trial according to the presence of incidental thyroid nodules detected on low-dose chest CT |
| title_full_unstemmed | Risk of thyroid cancer in a lung cancer screening population of the National Lung Screening Trial according to the presence of incidental thyroid nodules detected on low-dose chest CT |
| title_short | Risk of thyroid cancer in a lung cancer screening population of the National Lung Screening Trial according to the presence of incidental thyroid nodules detected on low-dose chest CT |
| title_sort | risk of thyroid cancer in a lung cancer screening population of the national lung screening trial according to the presence of incidental thyroid nodules detected on low dose chest ct |
| topic | thyroid neoplasms national lung screening trial incidental thyroid nodule low-dose chest ct ultrasound |
| url | http://www.e-ultrasonography.org/upload/usg-22111.pdf |
| work_keys_str_mv | AT hyobinseo riskofthyroidcancerinalungcancerscreeningpopulationofthenationallungscreeningtrialaccordingtothepresenceofincidentalthyroidnodulesdetectedonlowdosechestct AT kwangnamjin riskofthyroidcancerinalungcancerscreeningpopulationofthenationallungscreeningtrialaccordingtothepresenceofincidentalthyroidnodulesdetectedonlowdosechestct AT jisangpark riskofthyroidcancerinalungcancerscreeningpopulationofthenationallungscreeningtrialaccordingtothepresenceofincidentalthyroidnodulesdetectedonlowdosechestct AT koungmikang riskofthyroidcancerinalungcancerscreeningpopulationofthenationallungscreeningtrialaccordingtothepresenceofincidentalthyroidnodulesdetectedonlowdosechestct AT eunkyunglee riskofthyroidcancerinalungcancerscreeningpopulationofthenationallungscreeningtrialaccordingtothepresenceofincidentalthyroidnodulesdetectedonlowdosechestct AT jiyelee riskofthyroidcancerinalungcancerscreeningpopulationofthenationallungscreeningtrialaccordingtothepresenceofincidentalthyroidnodulesdetectedonlowdosechestct AT roheulyoo riskofthyroidcancerinalungcancerscreeningpopulationofthenationallungscreeningtrialaccordingtothepresenceofincidentalthyroidnodulesdetectedonlowdosechestct AT youngjoopark riskofthyroidcancerinalungcancerscreeningpopulationofthenationallungscreeningtrialaccordingtothepresenceofincidentalthyroidnodulesdetectedonlowdosechestct AT jihoonkim riskofthyroidcancerinalungcancerscreeningpopulationofthenationallungscreeningtrialaccordingtothepresenceofincidentalthyroidnodulesdetectedonlowdosechestct |