Mechanistic Coupling of a Novel in silico Cotyledon Perfusion Model and a Physiologically Based Pharmacokinetic Model to Predict Fetal Acetaminophen Pharmacokinetics at Delivery

Mechanistic Coupling of a Novel in silico Cotyledon Perfusion Model and a Physiologically Based Pharmacokinetic Model to Predict Fetal Acetaminophen Pharmacokinetics at Delivery

Little is known about placental drug transfer and fetal pharmacokinetics despite increasing drug use in pregnant women. While physiologically based pharmacokinetic (PBPK) models can help in some cases to shed light on this knowledge gap, adequate parameterization of placental drug transfer remains c...

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Bibliographic Details
Main Authors: Paola Mian, Bridget Nolan, John N. van den Anker, Kristel van Calsteren, Karel Allegaert, Nisha Lakhi, André Dallmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pediatrics
Subjects:
acetaminophen
ex vivo cotyledon perfusion
physiologically-based pharmacokinetics
placental transfer
maternal-fetal
pregnancy
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2021.733520/full

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