Sanitation and diarrhoea in infancy and CRP level at 18 years: the birth-to-twenty plus cohort
Background: Cardiometabolic disease is associated with chronic low-grade inflammation. While low birthweight, childhood stunting and rapid weight gain predict higher adult high-sensitivity C-reactive protein (hs-CRP) concentrations, associations between childhood infections and adulthood CRP are inc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-07-01
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| Series: | Annals of Human Biology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/03014460.2019.1657496 |
| _version_ | 1827818325696053248 |
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| author | Rihlat Said-Mohamed Aryeh D. Stein John M. Pettifor Shane A. Norris |
| author_facet | Rihlat Said-Mohamed Aryeh D. Stein John M. Pettifor Shane A. Norris |
| author_sort | Rihlat Said-Mohamed |
| collection | DOAJ |
| description | Background: Cardiometabolic disease is associated with chronic low-grade inflammation. While low birthweight, childhood stunting and rapid weight gain predict higher adult high-sensitivity C-reactive protein (hs-CRP) concentrations, associations between childhood infections and adulthood CRP are inconsistent. Aim: To assess the associations between sanitation, diarrhoea and a combined score of both from birth to age 2 years and hs-CRP at age 18 years, independently of early life nutrition and adult adiposity. Subjects and methods: This study collected data on sanitation and diarrhoea episodes from birth to 2 years on 756 participants of the Birth-to-Twenty Plus cohort, a birth cohort initiated in South Africa in 1990, and calculated a combined score of both variables. Anthropometry was measured at 2 years and 18 years and hs-CRP at 18 years. Results: Of the participants, 29.5% had no access to indoor flush sanitation and 38.2% experienced ≥1 diarrhoea episode between birth and 2 years. Not having access to indoor flush sanitation and experiencing ≥1 diarrhoea episodes were associated with 1.50 mg/L and 1.52 mg/L higher hs-CRP, respectively. Prevalence of both burdens in infancy was associated with a 2.18 mg/L higher hs-CRP. Conclusion: In this population, poor sanitation and diarrhoea in early life predict elevated CRP in young adulthood, independently of early life nutrition and adiposity. |
| first_indexed | 2024-03-12T00:46:12Z |
| format | Article |
| id | doaj.art-8f69091512ed46a5a6b7d91c0f490ee0 |
| institution | Directory Open Access Journal |
| issn | 0301-4460 1464-5033 |
| language | English |
| last_indexed | 2024-03-12T00:46:12Z |
| publishDate | 2019-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Human Biology |
| spelling | doaj.art-8f69091512ed46a5a6b7d91c0f490ee02023-09-14T15:36:11ZengTaylor & Francis GroupAnnals of Human Biology0301-44601464-50332019-07-0146541542410.1080/03014460.2019.16574961657496Sanitation and diarrhoea in infancy and CRP level at 18 years: the birth-to-twenty plus cohortRihlat Said-Mohamed0Aryeh D. Stein1John M. Pettifor2Shane A. Norris3University of WitwatersrandUniversity of WitwatersrandUniversity of WitwatersrandUniversity of WitwatersrandBackground: Cardiometabolic disease is associated with chronic low-grade inflammation. While low birthweight, childhood stunting and rapid weight gain predict higher adult high-sensitivity C-reactive protein (hs-CRP) concentrations, associations between childhood infections and adulthood CRP are inconsistent. Aim: To assess the associations between sanitation, diarrhoea and a combined score of both from birth to age 2 years and hs-CRP at age 18 years, independently of early life nutrition and adult adiposity. Subjects and methods: This study collected data on sanitation and diarrhoea episodes from birth to 2 years on 756 participants of the Birth-to-Twenty Plus cohort, a birth cohort initiated in South Africa in 1990, and calculated a combined score of both variables. Anthropometry was measured at 2 years and 18 years and hs-CRP at 18 years. Results: Of the participants, 29.5% had no access to indoor flush sanitation and 38.2% experienced ≥1 diarrhoea episode between birth and 2 years. Not having access to indoor flush sanitation and experiencing ≥1 diarrhoea episodes were associated with 1.50 mg/L and 1.52 mg/L higher hs-CRP, respectively. Prevalence of both burdens in infancy was associated with a 2.18 mg/L higher hs-CRP. Conclusion: In this population, poor sanitation and diarrhoea in early life predict elevated CRP in young adulthood, independently of early life nutrition and adiposity.http://dx.doi.org/10.1080/03014460.2019.1657496infectiongrowthlow-grade inflammationadiposityafrica |
| spellingShingle | Rihlat Said-Mohamed Aryeh D. Stein John M. Pettifor Shane A. Norris Sanitation and diarrhoea in infancy and CRP level at 18 years: the birth-to-twenty plus cohort Annals of Human Biology infection growth low-grade inflammation adiposity africa |
| title | Sanitation and diarrhoea in infancy and CRP level at 18 years: the birth-to-twenty plus cohort |
| title_full | Sanitation and diarrhoea in infancy and CRP level at 18 years: the birth-to-twenty plus cohort |
| title_fullStr | Sanitation and diarrhoea in infancy and CRP level at 18 years: the birth-to-twenty plus cohort |
| title_full_unstemmed | Sanitation and diarrhoea in infancy and CRP level at 18 years: the birth-to-twenty plus cohort |
| title_short | Sanitation and diarrhoea in infancy and CRP level at 18 years: the birth-to-twenty plus cohort |
| title_sort | sanitation and diarrhoea in infancy and crp level at 18 years the birth to twenty plus cohort |
| topic | infection growth low-grade inflammation adiposity africa |
| url | http://dx.doi.org/10.1080/03014460.2019.1657496 |
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