COVID-19 Affects Serum Brain-Derived Neurotrophic Factor and Neurofilament Light Chain in Aged Men: Implications for Morbidity and Mortality
Background and Methods: Severe COVID-19 is known to induce neurological damage (NeuroCOVID), mostly in aged individuals, by affecting brain-derived neurotrophic factor (BDNF), matrix metalloproteinases (MMP) 2 and 9 and the neurofilament light chain (NFL) pathways. Thus, the aim of this pilot study...
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MDPI AG
2023-02-01
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| Online Access: | https://www.mdpi.com/2073-4409/12/4/655 |
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| author | Carla Petrella Maria Antonella Zingaropoli Flavio Maria Ceci Patrizia Pasculli Tiziana Latronico Grazia Maria Liuzzi Maria Rosa Ciardi Antonio Angeloni Evaristo Ettorre Michela Menghi Christian Barbato Giampiero Ferraguti Antonio Minni Marco Fiore |
| author_facet | Carla Petrella Maria Antonella Zingaropoli Flavio Maria Ceci Patrizia Pasculli Tiziana Latronico Grazia Maria Liuzzi Maria Rosa Ciardi Antonio Angeloni Evaristo Ettorre Michela Menghi Christian Barbato Giampiero Ferraguti Antonio Minni Marco Fiore |
| author_sort | Carla Petrella |
| collection | DOAJ |
| description | Background and Methods: Severe COVID-19 is known to induce neurological damage (NeuroCOVID), mostly in aged individuals, by affecting brain-derived neurotrophic factor (BDNF), matrix metalloproteinases (MMP) 2 and 9 and the neurofilament light chain (NFL) pathways. Thus, the aim of this pilot study was to investigate BDNF, MMP-2, MMP-9, and NFL in the serum of aged men affected by COVID-19 at the beginning of the hospitalization period and characterized by different outcomes, i.e., attending a hospital ward or an intensive care unit (ICU) or with a fatal outcome. As a control group, we used a novelty of the study, unexposed age-matched men. We also correlated these findings with the routine blood parameters of the recruited individuals. Results: We found in COVID-19 individuals with severe or lethal outcomes disrupted serum BDNF, NFL, and MMP-2 presence and gross changes in ALT, GGT, LDH, IL-6, ferritin, and CRP. We also confirmed and extended previous data, using ROC analyses, showing that the ratio MMPs (2 and 9) versus BDNF and NFL might be a useful tool to predict a fatal COVID-19 outcome. Conclusions: Serum BDNF and NFL and/or their ratios with MMP-2 and MMP-9 could represent early predictors of NeuroCOVID in aged men. |
| first_indexed | 2024-03-11T09:01:02Z |
| format | Article |
| id | doaj.art-8f699157280146779d0396ef0c992752 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T09:01:02Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-8f699157280146779d0396ef0c9927522023-11-16T19:45:23ZengMDPI AGCells2073-44092023-02-0112465510.3390/cells12040655COVID-19 Affects Serum Brain-Derived Neurotrophic Factor and Neurofilament Light Chain in Aged Men: Implications for Morbidity and MortalityCarla Petrella0Maria Antonella Zingaropoli1Flavio Maria Ceci2Patrizia Pasculli3Tiziana Latronico4Grazia Maria Liuzzi5Maria Rosa Ciardi6Antonio Angeloni7Evaristo Ettorre8Michela Menghi9Christian Barbato10Giampiero Ferraguti11Antonio Minni12Marco Fiore13Institute of Biochemistry and Cell Biology (IBBC-CNR), Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale del Policlinico 155, 00185 Rome, ItalyDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale del Policlinico 155, 00185 Rome, ItalyDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari “Aldo Moro”, 70121 Bari, ItalyDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari “Aldo Moro”, 70121 Bari, ItalyDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale del Policlinico 155, 00185 Rome, ItalyDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Clinical, Internal Medicine, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Rome, ItalyInstitute of Biochemistry and Cell Biology (IBBC-CNR), Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Sensory Organs, Sapienza University of Rome, 00185 Rome, ItalyInstitute of Biochemistry and Cell Biology (IBBC-CNR), Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, ItalyBackground and Methods: Severe COVID-19 is known to induce neurological damage (NeuroCOVID), mostly in aged individuals, by affecting brain-derived neurotrophic factor (BDNF), matrix metalloproteinases (MMP) 2 and 9 and the neurofilament light chain (NFL) pathways. Thus, the aim of this pilot study was to investigate BDNF, MMP-2, MMP-9, and NFL in the serum of aged men affected by COVID-19 at the beginning of the hospitalization period and characterized by different outcomes, i.e., attending a hospital ward or an intensive care unit (ICU) or with a fatal outcome. As a control group, we used a novelty of the study, unexposed age-matched men. We also correlated these findings with the routine blood parameters of the recruited individuals. Results: We found in COVID-19 individuals with severe or lethal outcomes disrupted serum BDNF, NFL, and MMP-2 presence and gross changes in ALT, GGT, LDH, IL-6, ferritin, and CRP. We also confirmed and extended previous data, using ROC analyses, showing that the ratio MMPs (2 and 9) versus BDNF and NFL might be a useful tool to predict a fatal COVID-19 outcome. Conclusions: Serum BDNF and NFL and/or their ratios with MMP-2 and MMP-9 could represent early predictors of NeuroCOVID in aged men.https://www.mdpi.com/2073-4409/12/4/655BDNFNFLNGFMMP-2MMP-9NeuroCOVID |
| spellingShingle | Carla Petrella Maria Antonella Zingaropoli Flavio Maria Ceci Patrizia Pasculli Tiziana Latronico Grazia Maria Liuzzi Maria Rosa Ciardi Antonio Angeloni Evaristo Ettorre Michela Menghi Christian Barbato Giampiero Ferraguti Antonio Minni Marco Fiore COVID-19 Affects Serum Brain-Derived Neurotrophic Factor and Neurofilament Light Chain in Aged Men: Implications for Morbidity and Mortality Cells BDNF NFL NGF MMP-2 MMP-9 NeuroCOVID |
| title | COVID-19 Affects Serum Brain-Derived Neurotrophic Factor and Neurofilament Light Chain in Aged Men: Implications for Morbidity and Mortality |
| title_full | COVID-19 Affects Serum Brain-Derived Neurotrophic Factor and Neurofilament Light Chain in Aged Men: Implications for Morbidity and Mortality |
| title_fullStr | COVID-19 Affects Serum Brain-Derived Neurotrophic Factor and Neurofilament Light Chain in Aged Men: Implications for Morbidity and Mortality |
| title_full_unstemmed | COVID-19 Affects Serum Brain-Derived Neurotrophic Factor and Neurofilament Light Chain in Aged Men: Implications for Morbidity and Mortality |
| title_short | COVID-19 Affects Serum Brain-Derived Neurotrophic Factor and Neurofilament Light Chain in Aged Men: Implications for Morbidity and Mortality |
| title_sort | covid 19 affects serum brain derived neurotrophic factor and neurofilament light chain in aged men implications for morbidity and mortality |
| topic | BDNF NFL NGF MMP-2 MMP-9 NeuroCOVID |
| url | https://www.mdpi.com/2073-4409/12/4/655 |
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