Repurposing—a ray of hope in tackling extensively drug resistance in tuberculosis
Tuberculosis (TB) remains a serious concern more than two decades on from when the World Health Organization declared it a global health emergency. The alarming rise of antibiotic resistance in Mycobacterium tuberculosis, the etiological agent of TB, has made it exceedingly difficult to control the...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-03-01
|
| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971214017494 |
| _version_ | 1818483458031222784 |
|---|---|
| author | Arundhati Maitra Sadé Bates Trupti Kolvekar Padma V. Devarajan Juan D. Guzman Sanjib Bhakta |
| author_facet | Arundhati Maitra Sadé Bates Trupti Kolvekar Padma V. Devarajan Juan D. Guzman Sanjib Bhakta |
| author_sort | Arundhati Maitra |
| collection | DOAJ |
| description | Tuberculosis (TB) remains a serious concern more than two decades on from when the World Health Organization declared it a global health emergency. The alarming rise of antibiotic resistance in Mycobacterium tuberculosis, the etiological agent of TB, has made it exceedingly difficult to control the disease with the existing portfolio of anti-TB chemotherapy. The development of effective drugs with novel mechanism(s) of action is thus of paramount importance to tackle drug resistance. The development of novel chemical entities requires more than 10 years of research, requiring high-risk investment to become commercially available. Repurposing pre-existing drugs offers a solution to circumvent this mammoth investment in time and funds. In this context, several drugs with known safety and toxicity profiles have been evaluated against the TB pathogen and found to be efficacious against its different physiological states. As the endogenous targets of these drugs in the TB bacillus are most likely to be novel, there is minimal chance of cross-resistance with front-line anti-TB drugs. Also, reports that some of these drugs may potentially have multiple targets means that the possibility of the development of resistance against them is minimal. Thus repurposing existing molecules offers immense promise to tackle extensively drug-resistant TB infections. |
| first_indexed | 2024-12-10T15:42:14Z |
| format | Article |
| id | doaj.art-8f6b0c1894a044d1928e25536552c70f |
| institution | Directory Open Access Journal |
| issn | 1201-9712 1878-3511 |
| language | English |
| last_indexed | 2024-12-10T15:42:14Z |
| publishDate | 2015-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-8f6b0c1894a044d1928e25536552c70f2022-12-22T01:43:04ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112015-03-0132C505510.1016/j.ijid.2014.12.031Repurposing—a ray of hope in tackling extensively drug resistance in tuberculosisArundhati Maitra0Sadé Bates1Trupti Kolvekar2Padma V. Devarajan3Juan D. Guzman4Sanjib Bhakta5Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, London, UKMycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, London, UKMycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, London, UKDepartment of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N. P. Marg, Matunga, Mumbai, IndiaDepartamento de Química y Biología, División de Ciencias Básicas, Universidad del Norte, Barranquilla, ColombiaMycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, London, UKTuberculosis (TB) remains a serious concern more than two decades on from when the World Health Organization declared it a global health emergency. The alarming rise of antibiotic resistance in Mycobacterium tuberculosis, the etiological agent of TB, has made it exceedingly difficult to control the disease with the existing portfolio of anti-TB chemotherapy. The development of effective drugs with novel mechanism(s) of action is thus of paramount importance to tackle drug resistance. The development of novel chemical entities requires more than 10 years of research, requiring high-risk investment to become commercially available. Repurposing pre-existing drugs offers a solution to circumvent this mammoth investment in time and funds. In this context, several drugs with known safety and toxicity profiles have been evaluated against the TB pathogen and found to be efficacious against its different physiological states. As the endogenous targets of these drugs in the TB bacillus are most likely to be novel, there is minimal chance of cross-resistance with front-line anti-TB drugs. Also, reports that some of these drugs may potentially have multiple targets means that the possibility of the development of resistance against them is minimal. Thus repurposing existing molecules offers immense promise to tackle extensively drug-resistant TB infections.http://www.sciencedirect.com/science/article/pii/S1201971214017494Tuberculosis (TB)Mycobacterium tuberculosisAntibiotic resistanceRepurposingRepositioningWhole-cell phenotypic screening |
| spellingShingle | Arundhati Maitra Sadé Bates Trupti Kolvekar Padma V. Devarajan Juan D. Guzman Sanjib Bhakta Repurposing—a ray of hope in tackling extensively drug resistance in tuberculosis International Journal of Infectious Diseases Tuberculosis (TB) Mycobacterium tuberculosis Antibiotic resistance Repurposing Repositioning Whole-cell phenotypic screening |
| title | Repurposing—a ray of hope in tackling extensively drug resistance in tuberculosis |
| title_full | Repurposing—a ray of hope in tackling extensively drug resistance in tuberculosis |
| title_fullStr | Repurposing—a ray of hope in tackling extensively drug resistance in tuberculosis |
| title_full_unstemmed | Repurposing—a ray of hope in tackling extensively drug resistance in tuberculosis |
| title_short | Repurposing—a ray of hope in tackling extensively drug resistance in tuberculosis |
| title_sort | repurposing a ray of hope in tackling extensively drug resistance in tuberculosis |
| topic | Tuberculosis (TB) Mycobacterium tuberculosis Antibiotic resistance Repurposing Repositioning Whole-cell phenotypic screening |
| url | http://www.sciencedirect.com/science/article/pii/S1201971214017494 |
| work_keys_str_mv | AT arundhatimaitra repurposingarayofhopeintacklingextensivelydrugresistanceintuberculosis AT sadebates repurposingarayofhopeintacklingextensivelydrugresistanceintuberculosis AT truptikolvekar repurposingarayofhopeintacklingextensivelydrugresistanceintuberculosis AT padmavdevarajan repurposingarayofhopeintacklingextensivelydrugresistanceintuberculosis AT juandguzman repurposingarayofhopeintacklingextensivelydrugresistanceintuberculosis AT sanjibbhakta repurposingarayofhopeintacklingextensivelydrugresistanceintuberculosis |