Effects of different radical distal gastrectomy on postoperative inflammatory response and nutritional status in patients with gastric cancer
ObjectivesThe inflammatory response caused by gastric cancer surgery and the low nutritional status of patients with gastric cancer can cause growth of tumour cells, reduce immunity, and increase tumour burden. We investigated the effects of different surgical methods on postoperative inflammatory r...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2023.1112473/full |
| _version_ | 1827989984140853248 |
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| author | Xuefei Cheng Chuandong Wang Chuandong Wang Yi Liu Xiaojuan Zhang Liyuan Zhou Liyuan Zhou Zhizun Lin Zhizun Lin Wei Zeng Wei Zeng Lihang Liu Lihang Liu Changshun Yang Changshun Yang Weihua Li Weihua Li |
| author_facet | Xuefei Cheng Chuandong Wang Chuandong Wang Yi Liu Xiaojuan Zhang Liyuan Zhou Liyuan Zhou Zhizun Lin Zhizun Lin Wei Zeng Wei Zeng Lihang Liu Lihang Liu Changshun Yang Changshun Yang Weihua Li Weihua Li |
| author_sort | Xuefei Cheng |
| collection | DOAJ |
| description | ObjectivesThe inflammatory response caused by gastric cancer surgery and the low nutritional status of patients with gastric cancer can cause growth of tumour cells, reduce immunity, and increase tumour burden. We investigated the effects of different surgical methods on postoperative inflammatory response and nutritional status in patients with distal gastric cancer.MethodsClinical data of 249 patients who underwent radical distal gastrectomy for distal gastric cancer from February 2014 to April 2017 were retrospectively analysed. Patients were divided according to the surgical method (open distal gastrectomy [ODG], laparoscopic-assisted distal gastrectomy [LADG] and total laparoscopic distal gastrectomy [TLDG]). Characteristics of different surgical procedures, including inflammation parameters and nutritional indicators, and different time points (preoperatively, 1 day postoperatively, and 1 week postoperatively) were compared using non-parametric test analysis.ResultsAt postoperative day 1, white blood cell count [WBC], neutrophil count [N], neutrophil/lymphocyte ratio [NLR], and platelet/lymphocyte ratio [PLR] increased in the three groups, and ΔN and ΔNLR were significant; the smallest change was observed in TLDG (P < 0.05). Albumin [A]and prognostic nutrition index [PNI] significantly decreased; the smallest ΔA and ΔPNI, which were statistically significant, were noted in TLDG. One week postoperatively, WBC, N, NLR, and PLR decreased, and WBC, N, and NLR showed significant difference. A and PNI of the three groups increased after 1 week, and A and PNI showed significant differences.ConclusionPostoperative inflammatory response and nutritional status of patients with distal gastric cancer are associated with the surgical technique. TLDG has little influence on the inflammatory response and nutritional level compared with LADG and ODG. |
| first_indexed | 2024-04-10T00:28:54Z |
| format | Article |
| id | doaj.art-8f718b6e59fa42a3aa8578f446a9b1d8 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-10T00:28:54Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-8f718b6e59fa42a3aa8578f446a9b1d82023-03-15T04:54:32ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2023-03-011010.3389/fsurg.2023.11124731112473Effects of different radical distal gastrectomy on postoperative inflammatory response and nutritional status in patients with gastric cancerXuefei Cheng0Chuandong Wang1Chuandong Wang2Yi Liu3Xiaojuan Zhang4Liyuan Zhou5Liyuan Zhou6Zhizun Lin7Zhizun Lin8Wei Zeng9Wei Zeng10Lihang Liu11Lihang Liu12Changshun Yang13Changshun Yang14Weihua Li15Weihua Li16Shengli Clinical Medical College, Fujian Medical University, Fuzhou, ChinaShengli Clinical Medical College, Fujian Medical University, Fuzhou, ChinaDepartment of Surgical Oncology, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Endoscopy, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaFuzong Clinical Medical College, Fujian Medical University, Fuzhou, ChinaShengli Clinical Medical College, Fujian Medical University, Fuzhou, ChinaDepartment of Surgical Oncology, Fujian Provincial Hospital, Fuzhou, ChinaShengli Clinical Medical College, Fujian Medical University, Fuzhou, ChinaDepartment of Surgical Oncology, Fujian Provincial Hospital, Fuzhou, ChinaShengli Clinical Medical College, Fujian Medical University, Fuzhou, ChinaDepartment of Surgical Oncology, Fujian Provincial Hospital, Fuzhou, ChinaShengli Clinical Medical College, Fujian Medical University, Fuzhou, ChinaDepartment of Surgical Oncology, Fujian Provincial Hospital, Fuzhou, ChinaShengli Clinical Medical College, Fujian Medical University, Fuzhou, ChinaDepartment of Surgical Oncology, Fujian Provincial Hospital, Fuzhou, ChinaShengli Clinical Medical College, Fujian Medical University, Fuzhou, ChinaDepartment of Surgical Oncology, Fujian Provincial Hospital, Fuzhou, ChinaObjectivesThe inflammatory response caused by gastric cancer surgery and the low nutritional status of patients with gastric cancer can cause growth of tumour cells, reduce immunity, and increase tumour burden. We investigated the effects of different surgical methods on postoperative inflammatory response and nutritional status in patients with distal gastric cancer.MethodsClinical data of 249 patients who underwent radical distal gastrectomy for distal gastric cancer from February 2014 to April 2017 were retrospectively analysed. Patients were divided according to the surgical method (open distal gastrectomy [ODG], laparoscopic-assisted distal gastrectomy [LADG] and total laparoscopic distal gastrectomy [TLDG]). Characteristics of different surgical procedures, including inflammation parameters and nutritional indicators, and different time points (preoperatively, 1 day postoperatively, and 1 week postoperatively) were compared using non-parametric test analysis.ResultsAt postoperative day 1, white blood cell count [WBC], neutrophil count [N], neutrophil/lymphocyte ratio [NLR], and platelet/lymphocyte ratio [PLR] increased in the three groups, and ΔN and ΔNLR were significant; the smallest change was observed in TLDG (P < 0.05). Albumin [A]and prognostic nutrition index [PNI] significantly decreased; the smallest ΔA and ΔPNI, which were statistically significant, were noted in TLDG. One week postoperatively, WBC, N, NLR, and PLR decreased, and WBC, N, and NLR showed significant difference. A and PNI of the three groups increased after 1 week, and A and PNI showed significant differences.ConclusionPostoperative inflammatory response and nutritional status of patients with distal gastric cancer are associated with the surgical technique. TLDG has little influence on the inflammatory response and nutritional level compared with LADG and ODG.https://www.frontiersin.org/articles/10.3389/fsurg.2023.1112473/fullgastric cancertotal laparoscopic surgeryinflammationnutritional statusneutrophil/Lymphocyte ratioprognostic nutrition index |
| spellingShingle | Xuefei Cheng Chuandong Wang Chuandong Wang Yi Liu Xiaojuan Zhang Liyuan Zhou Liyuan Zhou Zhizun Lin Zhizun Lin Wei Zeng Wei Zeng Lihang Liu Lihang Liu Changshun Yang Changshun Yang Weihua Li Weihua Li Effects of different radical distal gastrectomy on postoperative inflammatory response and nutritional status in patients with gastric cancer Frontiers in Surgery gastric cancer total laparoscopic surgery inflammation nutritional status neutrophil/Lymphocyte ratio prognostic nutrition index |
| title | Effects of different radical distal gastrectomy on postoperative inflammatory response and nutritional status in patients with gastric cancer |
| title_full | Effects of different radical distal gastrectomy on postoperative inflammatory response and nutritional status in patients with gastric cancer |
| title_fullStr | Effects of different radical distal gastrectomy on postoperative inflammatory response and nutritional status in patients with gastric cancer |
| title_full_unstemmed | Effects of different radical distal gastrectomy on postoperative inflammatory response and nutritional status in patients with gastric cancer |
| title_short | Effects of different radical distal gastrectomy on postoperative inflammatory response and nutritional status in patients with gastric cancer |
| title_sort | effects of different radical distal gastrectomy on postoperative inflammatory response and nutritional status in patients with gastric cancer |
| topic | gastric cancer total laparoscopic surgery inflammation nutritional status neutrophil/Lymphocyte ratio prognostic nutrition index |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2023.1112473/full |
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