TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension
ABSTRACTBackground The triglyceride and glucose (TyG) index has been found to be significantly associated with a higher risk of mortality. However, there has been a lack of studies exploring the specific relationship between the TyG index and all-cause and cardiovascular mortality among middle-aged...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10641963.2023.2272581 |
| _version_ | 1797645309278420992 |
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| author | Jie Pang Linyan Qian Xiaoru Che Ping Lv Qiang Xu |
| author_facet | Jie Pang Linyan Qian Xiaoru Che Ping Lv Qiang Xu |
| author_sort | Jie Pang |
| collection | DOAJ |
| description | ABSTRACTBackground The triglyceride and glucose (TyG) index has been found to be significantly associated with a higher risk of mortality. However, there has been a lack of studies exploring the specific relationship between the TyG index and all-cause and cardiovascular mortality among middle-aged and elderly with hypertension.Methods A total of 3,614 participants with hypertension were enrolled from the National Health and Nutrition Examination Survey. The TyG index was calculated using the formula log [fasting triglycerides (mg/dL) x fasting glucose (mg/dL)/2]. The Cox proportional hazard ratios were used to evaluate the association between the TyG index and the risk of mortality.Results Over a follow-up period of 7.87 years, 991 all-cause death and 189 cardiovascular deaths occurred. Compared with the reference quartile, the multivariate-adjusted hazard ratios and 95% confidence intervals were 1.28 (1.07–1.53; p = .006) in the fourth quartile for all-cause mortality and 0.63 (0.42–0.96; p = .031) in the second quartile for cardiovascular mortality. Dose-response analysis indicated an L-shaped relationship.Conclusions The TyG index exhibited an L-shaped association with the risk of all-cause mortality among middle-aged and elderly with hypertension. |
| first_indexed | 2024-03-11T14:44:30Z |
| format | Article |
| id | doaj.art-8f71a74770ab4548842af78f0311b3fa |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T14:44:30Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-8f71a74770ab4548842af78f0311b3fa2023-10-30T12:26:46ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062023-12-0145110.1080/10641963.2023.2272581TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertensionJie Pang0Linyan Qian1Xiaoru Che2Ping Lv3Qiang Xu4Heart Center, Department of Cardiovascular Medicine, Zhejiang Provincical People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, ChinaHeart Center, Department of Cardiovascular Medicine, Zhejiang Provincical People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, ChinaHeart Center, Department of Cardiovascular Medicine, Zhejiang Provincical People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, ChinaHeart Center, Department of Cardiovascular Medicine, Zhejiang Provincical People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, ChinaHeart Center, Department of Cardiovascular Medicine, Zhejiang Provincical People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, ChinaABSTRACTBackground The triglyceride and glucose (TyG) index has been found to be significantly associated with a higher risk of mortality. However, there has been a lack of studies exploring the specific relationship between the TyG index and all-cause and cardiovascular mortality among middle-aged and elderly with hypertension.Methods A total of 3,614 participants with hypertension were enrolled from the National Health and Nutrition Examination Survey. The TyG index was calculated using the formula log [fasting triglycerides (mg/dL) x fasting glucose (mg/dL)/2]. The Cox proportional hazard ratios were used to evaluate the association between the TyG index and the risk of mortality.Results Over a follow-up period of 7.87 years, 991 all-cause death and 189 cardiovascular deaths occurred. Compared with the reference quartile, the multivariate-adjusted hazard ratios and 95% confidence intervals were 1.28 (1.07–1.53; p = .006) in the fourth quartile for all-cause mortality and 0.63 (0.42–0.96; p = .031) in the second quartile for cardiovascular mortality. Dose-response analysis indicated an L-shaped relationship.Conclusions The TyG index exhibited an L-shaped association with the risk of all-cause mortality among middle-aged and elderly with hypertension.https://www.tandfonline.com/doi/10.1080/10641963.2023.2272581Triglyceride glucose indexall-cause mortalitycardiovascular mortalityinsulin resistanceNHANES |
| spellingShingle | Jie Pang Linyan Qian Xiaoru Che Ping Lv Qiang Xu TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension Clinical and Experimental Hypertension Triglyceride glucose index all-cause mortality cardiovascular mortality insulin resistance NHANES |
| title | TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension |
| title_full | TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension |
| title_fullStr | TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension |
| title_full_unstemmed | TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension |
| title_short | TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension |
| title_sort | tyg index is a predictor of all cause mortality during the long term follow up in middle aged and elderly with hypertension |
| topic | Triglyceride glucose index all-cause mortality cardiovascular mortality insulin resistance NHANES |
| url | https://www.tandfonline.com/doi/10.1080/10641963.2023.2272581 |
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