Mechanistic considerations and biomarkers level in nickel-induced neurodegenerative diseases: An updated systematic review
The environment has been implicated to be a strong determinant of brain health with higher risk of neurodegeneration. The drastic rise in the prevalence of neurodegenerative diseases (NDDs) including Alzheimer’s disease (AD), Parkinson’s disease (PD), autism spectrum disorder (ASD), multiple scleros...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
|
| Series: | IBRO Neuroscience Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242122000501 |
| _version_ | 1811293171505692672 |
|---|---|
| author | Chidinma Promise Anyachor Donatus Baridoo Dooka Chinna Nneka Orish Cecilia Nwadiuto Amadi Beatrice Bocca Flavia Ruggieri Marta Senofonte Chiara Frazzoli Orish E. Orisakwe |
| author_facet | Chidinma Promise Anyachor Donatus Baridoo Dooka Chinna Nneka Orish Cecilia Nwadiuto Amadi Beatrice Bocca Flavia Ruggieri Marta Senofonte Chiara Frazzoli Orish E. Orisakwe |
| author_sort | Chidinma Promise Anyachor |
| collection | DOAJ |
| description | The environment has been implicated to be a strong determinant of brain health with higher risk of neurodegeneration. The drastic rise in the prevalence of neurodegenerative diseases (NDDs) including Alzheimer’s disease (AD), Parkinson’s disease (PD), autism spectrum disorder (ASD), multiple sclerosis (MS) etc., supports the idea that environmental factors may play a major role in NDDs aetiology. Nickel is one of the listed environmental metals reported to pose a serious threat to human health. This paper reported available studies on nickel level in NDDs covering both animal and human studies. Different databases were searched for articles reporting the main neurotoxicity mechanisms and the concentration of nickel in fluids and tissues of NDDs patients compared to controls. Data were extracted and synthesized by ensuring the articles were related to nickel and NDDs. Various mechanisms were reported as oxidative stress, disturbances in mitochondrial membrane potential, trace elements homeostasis destabilization, etc. Nickel was found elevated in biological fluids as blood, serum/plasma and CSF and in the brain of NDDs, as a consequence of unintentional exposure thorough nickel-contaminated air, food, water, and skin contact. In addition, after exposure to nickel, the concentration of markers of lipid peroxidation were increased, while some antioxidant defence systems decreased. Thus, the reduction in the exposure to nickel contaminant may hold a promise in reducing the incidence of NDDs. |
| first_indexed | 2024-04-13T04:57:09Z |
| format | Article |
| id | doaj.art-8f71bad76eb44694b9a5ac03591f058d |
| institution | Directory Open Access Journal |
| issn | 2667-2421 |
| language | English |
| last_indexed | 2024-04-13T04:57:09Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj.art-8f71bad76eb44694b9a5ac03591f058d2022-12-22T03:01:27ZengElsevierIBRO Neuroscience Reports2667-24212022-12-0113136146Mechanistic considerations and biomarkers level in nickel-induced neurodegenerative diseases: An updated systematic reviewChidinma Promise Anyachor0Donatus Baridoo Dooka1Chinna Nneka Orish2Cecilia Nwadiuto Amadi3Beatrice Bocca4Flavia Ruggieri5Marta Senofonte6Chiara Frazzoli7Orish E. Orisakwe8African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, 5323 Port Harcourt, Rivers State, NigeriaAfrican Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, 5323 Port Harcourt, Rivers State, NigeriaDepartment of Anatomy, College of Health Sciences University of Port Harcourt, PMB, 5323 Port Harcourt, Rivers State, Nigeria; Corresponding author.Department of Experimental Pharmacology & Toxicology, Faculty of Pharmacy, University of Port Harcourt, PMB, 5323 Port Harcourt, Rivers State, NigeriaDepartment of Environment and Health, Istituto Superiore di Sanità, Rome, ItalyDepartment of Environment and Health, Istituto Superiore di Sanità, Rome, ItalyDepartment of Environment and Health, Istituto Superiore di Sanità, Rome, ItalyDepartment for Cardiovascular, Endocrine-Metabolic Diseases, and Aging, Istituto Superiore di Sanità, Rome Viale Regina Elena, 29900161 Roma, ItalyAfrican Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, 5323 Port Harcourt, Rivers State, Nigeria; Department of Anatomy, College of Health Sciences University of Port Harcourt, PMB, 5323 Port Harcourt, Rivers State, Nigeria; Corresponding author at: African Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB, 5323 Port Harcourt, Rivers State, Nigeria.The environment has been implicated to be a strong determinant of brain health with higher risk of neurodegeneration. The drastic rise in the prevalence of neurodegenerative diseases (NDDs) including Alzheimer’s disease (AD), Parkinson’s disease (PD), autism spectrum disorder (ASD), multiple sclerosis (MS) etc., supports the idea that environmental factors may play a major role in NDDs aetiology. Nickel is one of the listed environmental metals reported to pose a serious threat to human health. This paper reported available studies on nickel level in NDDs covering both animal and human studies. Different databases were searched for articles reporting the main neurotoxicity mechanisms and the concentration of nickel in fluids and tissues of NDDs patients compared to controls. Data were extracted and synthesized by ensuring the articles were related to nickel and NDDs. Various mechanisms were reported as oxidative stress, disturbances in mitochondrial membrane potential, trace elements homeostasis destabilization, etc. Nickel was found elevated in biological fluids as blood, serum/plasma and CSF and in the brain of NDDs, as a consequence of unintentional exposure thorough nickel-contaminated air, food, water, and skin contact. In addition, after exposure to nickel, the concentration of markers of lipid peroxidation were increased, while some antioxidant defence systems decreased. Thus, the reduction in the exposure to nickel contaminant may hold a promise in reducing the incidence of NDDs.http://www.sciencedirect.com/science/article/pii/S2667242122000501NickelEnvironmental exposureNeurotoxicityOxidative stressMitochondrial dysfunctionsBiomarkers |
| spellingShingle | Chidinma Promise Anyachor Donatus Baridoo Dooka Chinna Nneka Orish Cecilia Nwadiuto Amadi Beatrice Bocca Flavia Ruggieri Marta Senofonte Chiara Frazzoli Orish E. Orisakwe Mechanistic considerations and biomarkers level in nickel-induced neurodegenerative diseases: An updated systematic review IBRO Neuroscience Reports Nickel Environmental exposure Neurotoxicity Oxidative stress Mitochondrial dysfunctions Biomarkers |
| title | Mechanistic considerations and biomarkers level in nickel-induced neurodegenerative diseases: An updated systematic review |
| title_full | Mechanistic considerations and biomarkers level in nickel-induced neurodegenerative diseases: An updated systematic review |
| title_fullStr | Mechanistic considerations and biomarkers level in nickel-induced neurodegenerative diseases: An updated systematic review |
| title_full_unstemmed | Mechanistic considerations and biomarkers level in nickel-induced neurodegenerative diseases: An updated systematic review |
| title_short | Mechanistic considerations and biomarkers level in nickel-induced neurodegenerative diseases: An updated systematic review |
| title_sort | mechanistic considerations and biomarkers level in nickel induced neurodegenerative diseases an updated systematic review |
| topic | Nickel Environmental exposure Neurotoxicity Oxidative stress Mitochondrial dysfunctions Biomarkers |
| url | http://www.sciencedirect.com/science/article/pii/S2667242122000501 |
| work_keys_str_mv | AT chidinmapromiseanyachor mechanisticconsiderationsandbiomarkerslevelinnickelinducedneurodegenerativediseasesanupdatedsystematicreview AT donatusbaridoodooka mechanisticconsiderationsandbiomarkerslevelinnickelinducedneurodegenerativediseasesanupdatedsystematicreview AT chinnannekaorish mechanisticconsiderationsandbiomarkerslevelinnickelinducedneurodegenerativediseasesanupdatedsystematicreview AT cecilianwadiutoamadi mechanisticconsiderationsandbiomarkerslevelinnickelinducedneurodegenerativediseasesanupdatedsystematicreview AT beatricebocca mechanisticconsiderationsandbiomarkerslevelinnickelinducedneurodegenerativediseasesanupdatedsystematicreview AT flaviaruggieri mechanisticconsiderationsandbiomarkerslevelinnickelinducedneurodegenerativediseasesanupdatedsystematicreview AT martasenofonte mechanisticconsiderationsandbiomarkerslevelinnickelinducedneurodegenerativediseasesanupdatedsystematicreview AT chiarafrazzoli mechanisticconsiderationsandbiomarkerslevelinnickelinducedneurodegenerativediseasesanupdatedsystematicreview AT orisheorisakwe mechanisticconsiderationsandbiomarkerslevelinnickelinducedneurodegenerativediseasesanupdatedsystematicreview |