Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord

Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord

Dextromethorphan (DM) is a dextrorotary morphinan and a widely used component of cough medicine. Relatively high doses of DM in combination with quinidine are used for the treatment of mood disorders for patients with multiple sclerosis (MS). However, at lower doses, morphinans exert anti-inflammato...

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Bibliographic Details
Main Authors: Olga V. Chechneva, Florian Mayrhofer, Daniel J. Daugherty, David E. Pleasure, Jau-Shyong Hong, Wenbin Deng
Format: Article
Language:English
Published: Elsevier 2011-10-01
Series:Neurobiology of Disease
Subjects:
Low dose dextromethorphan
EAE
NOX2 NADPH oxidase
Microglia
CNS infiltration
Demyelination
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111002026

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