A Review of the Mechanism of Vascular Endothelial Injury in Immunoglobulin A Vasculitis
Immunoglobulin A (IgA) vasculitis (IgAV), also known as Henoch-Schönlein purpura, is the most common form of childhood vasculitis. It is characterized by cutaneous hemorrhage, resulting from red blood cell leakage into the skin or mucosae, possibly caused by damage to small blood vessels. These acut...
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| Format: | Article |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.833954/full |
| _version_ | 1818992298921295872 |
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| author | Shanshan Xu Shanshan Han Yanlin Dai Long Wang Xia Zhang Ying Ding |
| author_facet | Shanshan Xu Shanshan Han Yanlin Dai Long Wang Xia Zhang Ying Ding |
| author_sort | Shanshan Xu |
| collection | DOAJ |
| description | Immunoglobulin A (IgA) vasculitis (IgAV), also known as Henoch-Schönlein purpura, is the most common form of childhood vasculitis. It is characterized by cutaneous hemorrhage, resulting from red blood cell leakage into the skin or mucosae, possibly caused by damage to small blood vessels. These acute symptoms usually disappear without treatment. Endothelial cells are distributed on the inner surfaces of blood vessels and lymphatic vessels, and have important functions in metabolism and endocrine function, as well as being the primary targets of external stimuli and endogenous immune activity. Injury to endothelial cells is a feature of IgA vasculitis. Endothelial cell damage may be related to the deposition of immune complexes, the activation of complement, inflammatory factors, and chemokines, oxidative stress, hemodynamics, and coagulation factors. Both epigenetic mechanisms and genetic diversity provide a genetic background for endothelial cell injury. Here, research on the role of endothelial cells in allergic IgA vasculitis is reviewed. |
| first_indexed | 2024-12-20T20:23:57Z |
| format | Article |
| id | doaj.art-8f734809bec543819b1f01bb898dfdd0 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-20T20:23:57Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-8f734809bec543819b1f01bb898dfdd02022-12-21T19:27:30ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-03-011310.3389/fphys.2022.833954833954A Review of the Mechanism of Vascular Endothelial Injury in Immunoglobulin A VasculitisShanshan Xu0Shanshan Han1Yanlin Dai2Long Wang3Xia Zhang4Ying Ding5Pediatric Kidney Disease Center, Henan University of Traditional Chinese Medicine, Zhengzhou, ChinaPediatric Kidney Disease Center, Henan University of Traditional Chinese Medicine, Zhengzhou, ChinaPediatric Kidney Disease Center, Henan University of Traditional Chinese Medicine, Zhengzhou, ChinaPediatric Kidney Disease Center, Henan University of Traditional Chinese Medicine, Zhengzhou, ChinaPediatric Kidney Disease Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, ChinaPediatric Kidney Disease Center, Henan University of Traditional Chinese Medicine, Zhengzhou, ChinaImmunoglobulin A (IgA) vasculitis (IgAV), also known as Henoch-Schönlein purpura, is the most common form of childhood vasculitis. It is characterized by cutaneous hemorrhage, resulting from red blood cell leakage into the skin or mucosae, possibly caused by damage to small blood vessels. These acute symptoms usually disappear without treatment. Endothelial cells are distributed on the inner surfaces of blood vessels and lymphatic vessels, and have important functions in metabolism and endocrine function, as well as being the primary targets of external stimuli and endogenous immune activity. Injury to endothelial cells is a feature of IgA vasculitis. Endothelial cell damage may be related to the deposition of immune complexes, the activation of complement, inflammatory factors, and chemokines, oxidative stress, hemodynamics, and coagulation factors. Both epigenetic mechanisms and genetic diversity provide a genetic background for endothelial cell injury. Here, research on the role of endothelial cells in allergic IgA vasculitis is reviewed.https://www.frontiersin.org/articles/10.3389/fphys.2022.833954/fullsystem of complementvascular endothelial injurymetabolomics markersgene polymorphismsimmunoglobulin A vasculitis |
| spellingShingle | Shanshan Xu Shanshan Han Yanlin Dai Long Wang Xia Zhang Ying Ding A Review of the Mechanism of Vascular Endothelial Injury in Immunoglobulin A Vasculitis Frontiers in Physiology system of complement vascular endothelial injury metabolomics markers gene polymorphisms immunoglobulin A vasculitis |
| title | A Review of the Mechanism of Vascular Endothelial Injury in Immunoglobulin A Vasculitis |
| title_full | A Review of the Mechanism of Vascular Endothelial Injury in Immunoglobulin A Vasculitis |
| title_fullStr | A Review of the Mechanism of Vascular Endothelial Injury in Immunoglobulin A Vasculitis |
| title_full_unstemmed | A Review of the Mechanism of Vascular Endothelial Injury in Immunoglobulin A Vasculitis |
| title_short | A Review of the Mechanism of Vascular Endothelial Injury in Immunoglobulin A Vasculitis |
| title_sort | review of the mechanism of vascular endothelial injury in immunoglobulin a vasculitis |
| topic | system of complement vascular endothelial injury metabolomics markers gene polymorphisms immunoglobulin A vasculitis |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.833954/full |
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