Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis
Atherosclerosis (AS) is universally defined as chronic vascular inflammation induced by dyslipidaemia, obesity, hypertension, diabetes and other risk factors. Extracellular vesicles as information transmitters regulate intracellular interactions and their important cargo circular RNAs are involved i...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-04-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.804247/full |
| _version_ | 1818364567506386944 |
|---|---|
| author | Cheng Wen Bowei Li Lei Nie Ling Mao Yuanpeng Xia |
| author_facet | Cheng Wen Bowei Li Lei Nie Ling Mao Yuanpeng Xia |
| author_sort | Cheng Wen |
| collection | DOAJ |
| description | Atherosclerosis (AS) is universally defined as chronic vascular inflammation induced by dyslipidaemia, obesity, hypertension, diabetes and other risk factors. Extracellular vesicles as information transmitters regulate intracellular interactions and their important cargo circular RNAs are involved in the pathological process of AS. In this review, we summarize the current data to elucidate the emerging roles of extracellular vesicle-derived circular RNAs (EV-circRNAs) in AS and the mechanism by which EV-circRNAs affect the development of AS. Additionally, we discuss their vital role in the progression from risk factors to AS and highlight their great potential for use as diagnostic biomarkers of and novel therapeutic strategies for AS. |
| first_indexed | 2024-12-13T22:06:25Z |
| format | Article |
| id | doaj.art-8f73fbaf68ae44b5af13b700286ed115 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-13T22:06:25Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-8f73fbaf68ae44b5af13b700286ed1152022-12-21T23:29:50ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-04-011010.3389/fcell.2022.804247804247Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in AtherosclerosisCheng WenBowei LiLei NieLing MaoYuanpeng XiaAtherosclerosis (AS) is universally defined as chronic vascular inflammation induced by dyslipidaemia, obesity, hypertension, diabetes and other risk factors. Extracellular vesicles as information transmitters regulate intracellular interactions and their important cargo circular RNAs are involved in the pathological process of AS. In this review, we summarize the current data to elucidate the emerging roles of extracellular vesicle-derived circular RNAs (EV-circRNAs) in AS and the mechanism by which EV-circRNAs affect the development of AS. Additionally, we discuss their vital role in the progression from risk factors to AS and highlight their great potential for use as diagnostic biomarkers of and novel therapeutic strategies for AS.https://www.frontiersin.org/articles/10.3389/fcell.2022.804247/fullatherosclerosisextracellular vesiclecircular RNA (circRNA)Biomarker (BM)therapy |
| spellingShingle | Cheng Wen Bowei Li Lei Nie Ling Mao Yuanpeng Xia Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis Frontiers in Cell and Developmental Biology atherosclerosis extracellular vesicle circular RNA (circRNA) Biomarker (BM) therapy |
| title | Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis |
| title_full | Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis |
| title_fullStr | Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis |
| title_full_unstemmed | Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis |
| title_short | Emerging Roles of Extracellular Vesicle-Delivered Circular RNAs in Atherosclerosis |
| title_sort | emerging roles of extracellular vesicle delivered circular rnas in atherosclerosis |
| topic | atherosclerosis extracellular vesicle circular RNA (circRNA) Biomarker (BM) therapy |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.804247/full |
| work_keys_str_mv | AT chengwen emergingrolesofextracellularvesicledeliveredcircularrnasinatherosclerosis AT boweili emergingrolesofextracellularvesicledeliveredcircularrnasinatherosclerosis AT leinie emergingrolesofextracellularvesicledeliveredcircularrnasinatherosclerosis AT lingmao emergingrolesofextracellularvesicledeliveredcircularrnasinatherosclerosis AT yuanpengxia emergingrolesofextracellularvesicledeliveredcircularrnasinatherosclerosis |