Evolving Risk of Acute Kidney Injury in COVID-19 Hospitalized Patients: A Single Center Retrospective Study
<i>Background and Objectives</i>: Within a year, COVID-19 has advanced from an outbreak to a pandemic, spreading rapidly and globally with devastating impact. The pathophysiological link between COVID-19 and acute kidney injury (AKI) is currently being debated among scientists. While som...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/3/443 |
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| author | Fahad D. Algahtani Mohamed T. Elabbasy Fares Alshammari Amira Atta Ayman M. El-Fateh Mohamed E. Ghoniem |
| author_facet | Fahad D. Algahtani Mohamed T. Elabbasy Fares Alshammari Amira Atta Ayman M. El-Fateh Mohamed E. Ghoniem |
| author_sort | Fahad D. Algahtani |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Within a year, COVID-19 has advanced from an outbreak to a pandemic, spreading rapidly and globally with devastating impact. The pathophysiological link between COVID-19 and acute kidney injury (AKI) is currently being debated among scientists. While some studies have concluded that the mechanisms of AKI in COVID-19 patients are complex and not fully understood, others have claimed that AKI is a rare complication of COVID-19-related disorders. Considering this information gap and its possible influence on COVID-19-associated AKI management, our study aimed to explore the prevalence of AKI and to identify possible risk factors associated with AKI development among COVID-19 hospitalized patients. <i>Materials and Methods</i>: A retrospective cohort study included 83 laboratory-confirmed COVID-19 patients hospitalized at the isolation department in a tertiary hospital in Zagazig City, Egypt between June and August 2020. Patients younger than 18 years of age, those diagnosed with end-stage kidney disease, or those on nephrotoxic medications were excluded. All study participants had a complete blood count, liver and renal function tests, hemostasis parameters examined, inflammatory markers, serum electrolytes, routine urinalysis, arterial blood gas, and non-enhanced chest and abdominal computer tomography (CT) scans. <i>Results</i>: Of the 83 patients, AKI developed in 24 (28.9%) of them, of which 70.8% were in stage 1, 8.3% in stage 2, and 20.8% in stage 3. Patients with AKI were older than patients without AKI, with hypertension and diabetes being the most common comorbidities. Risk factors for AKI include increased age, hypertension, diabetes mellitus, and a higher sequential organ failure assessment (SOFA) score. <i>Conclusions</i>: AKI occurs in a considerable percentage of patients with COVID-19, especially in elderly males, those with hypertension, diabetes, and a higher sequential organ failure assessment (SOFA) score. Hence, the presence of AKI should be taken into account as an important index within the risk spectrum of disease severity for COVID-19 patients. |
| first_indexed | 2024-03-09T13:23:31Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T13:23:31Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj.art-8f743ba1567c483e9452fde19cf649052023-11-30T21:27:06ZengMDPI AGMedicina1010-660X1648-91442022-03-0158344310.3390/medicina58030443Evolving Risk of Acute Kidney Injury in COVID-19 Hospitalized Patients: A Single Center Retrospective StudyFahad D. Algahtani0Mohamed T. Elabbasy1Fares Alshammari2Amira Atta3Ayman M. El-Fateh4Mohamed E. Ghoniem5Department of Public Health, College of Public Health and Health Informatics, University of Ha’il, Ha’il 2440, Saudi ArabiaDepartment of Public Health, College of Public Health and Health Informatics, University of Ha’il, Ha’il 2440, Saudi ArabiaDepartment of Health Informatics, College of Public Health and Health Informatics, University of Ha’il, Ha’il 2440, Saudi ArabiaDepartment of Health Informatics, College of Public Health and Health Informatics, University of Ha’il, Ha’il 2440, Saudi ArabiaDepartment of Internal Medicine, AL-AHRAR Teaching Hospital, Zagazig 44919, EgyptDepartment of Internal Medicine, College of Medicine, University of Ha’il, Ha’il 2240, Saudi Arabia<i>Background and Objectives</i>: Within a year, COVID-19 has advanced from an outbreak to a pandemic, spreading rapidly and globally with devastating impact. The pathophysiological link between COVID-19 and acute kidney injury (AKI) is currently being debated among scientists. While some studies have concluded that the mechanisms of AKI in COVID-19 patients are complex and not fully understood, others have claimed that AKI is a rare complication of COVID-19-related disorders. Considering this information gap and its possible influence on COVID-19-associated AKI management, our study aimed to explore the prevalence of AKI and to identify possible risk factors associated with AKI development among COVID-19 hospitalized patients. <i>Materials and Methods</i>: A retrospective cohort study included 83 laboratory-confirmed COVID-19 patients hospitalized at the isolation department in a tertiary hospital in Zagazig City, Egypt between June and August 2020. Patients younger than 18 years of age, those diagnosed with end-stage kidney disease, or those on nephrotoxic medications were excluded. All study participants had a complete blood count, liver and renal function tests, hemostasis parameters examined, inflammatory markers, serum electrolytes, routine urinalysis, arterial blood gas, and non-enhanced chest and abdominal computer tomography (CT) scans. <i>Results</i>: Of the 83 patients, AKI developed in 24 (28.9%) of them, of which 70.8% were in stage 1, 8.3% in stage 2, and 20.8% in stage 3. Patients with AKI were older than patients without AKI, with hypertension and diabetes being the most common comorbidities. Risk factors for AKI include increased age, hypertension, diabetes mellitus, and a higher sequential organ failure assessment (SOFA) score. <i>Conclusions</i>: AKI occurs in a considerable percentage of patients with COVID-19, especially in elderly males, those with hypertension, diabetes, and a higher sequential organ failure assessment (SOFA) score. Hence, the presence of AKI should be taken into account as an important index within the risk spectrum of disease severity for COVID-19 patients.https://www.mdpi.com/1648-9144/58/3/443coronavirus disease (COVID-19)acute kidney injury (AKI)sequential organ failure assessment (SOFA) |
| spellingShingle | Fahad D. Algahtani Mohamed T. Elabbasy Fares Alshammari Amira Atta Ayman M. El-Fateh Mohamed E. Ghoniem Evolving Risk of Acute Kidney Injury in COVID-19 Hospitalized Patients: A Single Center Retrospective Study Medicina coronavirus disease (COVID-19) acute kidney injury (AKI) sequential organ failure assessment (SOFA) |
| title | Evolving Risk of Acute Kidney Injury in COVID-19 Hospitalized Patients: A Single Center Retrospective Study |
| title_full | Evolving Risk of Acute Kidney Injury in COVID-19 Hospitalized Patients: A Single Center Retrospective Study |
| title_fullStr | Evolving Risk of Acute Kidney Injury in COVID-19 Hospitalized Patients: A Single Center Retrospective Study |
| title_full_unstemmed | Evolving Risk of Acute Kidney Injury in COVID-19 Hospitalized Patients: A Single Center Retrospective Study |
| title_short | Evolving Risk of Acute Kidney Injury in COVID-19 Hospitalized Patients: A Single Center Retrospective Study |
| title_sort | evolving risk of acute kidney injury in covid 19 hospitalized patients a single center retrospective study |
| topic | coronavirus disease (COVID-19) acute kidney injury (AKI) sequential organ failure assessment (SOFA) |
| url | https://www.mdpi.com/1648-9144/58/3/443 |
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