Promoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC)

Promoter hypomethylation mediated upregulation of MicroRNA-10b-3p targets FOXO3 to promote the progression of esophageal squamous cell carcinoma (ESCC)

Abstract Background Esophageal cancer is a high incident cancer worldwide with poor survival and limited therapeutic options. Alterations of microRNAs are common in cancers, and many of these micro RNAs are potential therapeutic and diagnostic targets to treat these cancers. miR-10b-3p located in ch...

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Bibliographic Details
Main Authors: Yi-fang Lu, Jia-rui Yu, Zhao Yang, Guan-xia Zhu, Peng Gao, Huan Wang, Si-yuan Chen, Jie Zhang, Mei-yue Liu, Yi Niu, Xiao-mei Wei, Wei Wang, Feng-jin Ye, Li-xin Zhang, Yue Zhao, Guo-gui Sun
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
microRNAs
Esophageal squamous cell carcinoma
Hypomethylation
Biomarker
Therapeutic target
Online Access:http://link.springer.com/article/10.1186/s13046-018-0966-1

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