Prospects for the use of statins in antiviral therapy
Inhibitors of hydroxymethylglutaryl-CoA reductase, in addition to suppressing cholesterol synthesis, have an antiviral effect. Clinical studies have shown antiviral efficacy of statins against COVID-19, HCV, HBV, RSV, HIV, influenza viruses. The ability of statins to inhibit influenza viruses, COVID...
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| Format: | Article |
| Language: | Russian |
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Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy
2023-03-01
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| Series: | Клиническая микробиология и антимикробная химиотерапия |
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| Online Access: | https://cmac-journal.ru/publication/2023/1/cmac-2023-t25-n1-p56/cmac-2023-t25-n1-p56.pdf |
| _version_ | 1797824046997438464 |
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| author | Mustafin R.N. |
| author_facet | Mustafin R.N. |
| author_sort | Mustafin R.N. |
| collection | DOAJ |
| description | Inhibitors of hydroxymethylglutaryl-CoA reductase, in addition to suppressing cholesterol synthesis, have an antiviral effect. Clinical studies have shown antiviral efficacy of statins against COVID-19, HCV, HBV, RSV, HIV, influenza viruses. The ability of statins to inhibit influenza viruses, COVID-19, RSV, HIV, as well as Ebola, Zika, Dengue, Coxsackie, rotaviruses, ADV, HDV, HHV was experimentally confirmed. Statins can also enhance the effects of antiviral drugs, making them more effective in treating infections. Therefore, the use of statins in the complex therapy of viral infections is promising. In addition, the role of influenza viruses, T-cell leukemia and herpesviruses, HIV, HBV, HCV, HPV in the development of atherosclerosis has been identified, so the use of statins in complex treatment is also necessary to correct endothelial dysfunction that occurs under the influence of viruses. Since the activity of retroelements that are evolutionarily related to exogenous viruses increases with aging, it has been suggested that retrotransposons can also be targets for statins. This is evidenced by a change in the expression of non-coding RNAs under the action of statins, since the key sources of non-coding RNAs are retroelements. This property may be an additional factor in the prescription of statins to increase life expectancy, in addition to the prevention and treatment of atherosclerosis, since pathological activation of retroelements are the causes of aging. Viruses, like retroelements, are involved in the pathogenesis of malignant neoplasms, in the treatment of which statins have shown their effectiveness and the ability to enhance the effect of anticancer drugs, overcoming chemoresistance (similar to the potentiation of antiviral drugs). One of the mechanisms of this activity of statins may be their effect on retroelements and viruses. |
| first_indexed | 2024-03-13T10:33:10Z |
| format | Article |
| id | doaj.art-8f76915092054105831758df6e42ea81 |
| institution | Directory Open Access Journal |
| issn | 1684-4386 2686-9586 |
| language | Russian |
| last_indexed | 2024-03-13T10:33:10Z |
| publishDate | 2023-03-01 |
| publisher | Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy |
| record_format | Article |
| series | Клиническая микробиология и антимикробная химиотерапия |
| spelling | doaj.art-8f76915092054105831758df6e42ea812023-05-18T08:45:18ZrusInterregional Association for Clinical Microbiology and Antimicrobial ChemotherapyКлиническая микробиология и антимикробная химиотерапия1684-43862686-95862023-03-01251566710.36488/cmac.2023.1.56-67cmac-2023-t25-n1-p56Prospects for the use of statins in antiviral therapyMustafin R.N.0Bashkir State Medical University, Ufa, RussiaInhibitors of hydroxymethylglutaryl-CoA reductase, in addition to suppressing cholesterol synthesis, have an antiviral effect. Clinical studies have shown antiviral efficacy of statins against COVID-19, HCV, HBV, RSV, HIV, influenza viruses. The ability of statins to inhibit influenza viruses, COVID-19, RSV, HIV, as well as Ebola, Zika, Dengue, Coxsackie, rotaviruses, ADV, HDV, HHV was experimentally confirmed. Statins can also enhance the effects of antiviral drugs, making them more effective in treating infections. Therefore, the use of statins in the complex therapy of viral infections is promising. In addition, the role of influenza viruses, T-cell leukemia and herpesviruses, HIV, HBV, HCV, HPV in the development of atherosclerosis has been identified, so the use of statins in complex treatment is also necessary to correct endothelial dysfunction that occurs under the influence of viruses. Since the activity of retroelements that are evolutionarily related to exogenous viruses increases with aging, it has been suggested that retrotransposons can also be targets for statins. This is evidenced by a change in the expression of non-coding RNAs under the action of statins, since the key sources of non-coding RNAs are retroelements. This property may be an additional factor in the prescription of statins to increase life expectancy, in addition to the prevention and treatment of atherosclerosis, since pathological activation of retroelements are the causes of aging. Viruses, like retroelements, are involved in the pathogenesis of malignant neoplasms, in the treatment of which statins have shown their effectiveness and the ability to enhance the effect of anticancer drugs, overcoming chemoresistance (similar to the potentiation of antiviral drugs). One of the mechanisms of this activity of statins may be their effect on retroelements and viruses.https://cmac-journal.ru/publication/2023/1/cmac-2023-t25-n1-p56/cmac-2023-t25-n1-p56.pdfatherosclerosisvirusesmevalonateretroelementsstatins |
| spellingShingle | Mustafin R.N. Prospects for the use of statins in antiviral therapy Клиническая микробиология и антимикробная химиотерапия atherosclerosis viruses mevalonate retroelements statins |
| title | Prospects for the use of statins in antiviral therapy |
| title_full | Prospects for the use of statins in antiviral therapy |
| title_fullStr | Prospects for the use of statins in antiviral therapy |
| title_full_unstemmed | Prospects for the use of statins in antiviral therapy |
| title_short | Prospects for the use of statins in antiviral therapy |
| title_sort | prospects for the use of statins in antiviral therapy |
| topic | atherosclerosis viruses mevalonate retroelements statins |
| url | https://cmac-journal.ru/publication/2023/1/cmac-2023-t25-n1-p56/cmac-2023-t25-n1-p56.pdf |
| work_keys_str_mv | AT mustafinrn prospectsfortheuseofstatinsinantiviraltherapy |