Association of carotid intima-media thickness with the risk of sudden sensorineural hearing loss
Cardiovascular factors are associated with the pathophysiological features and risk of sudden sensorineural hearing loss (SSNHL). However, little is known about the link between carotid intima-media thickness (IMT), SSNHL risk, and their respective treatment outcomes. In this study, we retrospective...
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PeerJ Inc.
2020-06-01
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| author | Chun-Hsien Ho Teng-Yeow Tan Chung-Feng Hwang Wei-Che Lin Ching-Nung Wu Chao-Hui Yang |
| author_facet | Chun-Hsien Ho Teng-Yeow Tan Chung-Feng Hwang Wei-Che Lin Ching-Nung Wu Chao-Hui Yang |
| author_sort | Chun-Hsien Ho |
| collection | DOAJ |
| description | Cardiovascular factors are associated with the pathophysiological features and risk of sudden sensorineural hearing loss (SSNHL). However, little is known about the link between carotid intima-media thickness (IMT), SSNHL risk, and their respective treatment outcomes. In this study, we retrospectively reviewed 47 SSNHL cases and 33 control subjects from a single medical center and compared their demographic data and clinical characteristics, including their carotid IMT and audiological data. Of the 80 enrolled subjects, the proportion of those with high carotid IMT was greater in the SSNHL group (53.2%) than in the control group (21.2%), with an odds ratio (OR) of 4.22 (95% confidence interval (CI) [1.53–11.61], P = 0.004). Notably, high carotid IMT was more common in female SSNHL patients than females in the control group (54.2% vs. 12.5%; OR, 8.27 (95% CI [1.53–44.62]), P = 0.008), particularly in female patients ≥50 years of age (75% vs. 25%; OR, 9.0 (95% CI [1.27–63.9]), P = 0.032). The multivariate regression analyses showed the association between high carotid IMT and SSNHL with an adjusted OR of 4.655 (95% CI [1.348–16.076], P = 0.015), particularly in female SSNHL patients (adjusted OR, 9.818 (95% CI [1.064–90.587], P = 0.044). The carotid IMT was not associated with the treatment outcomes of SSNHL. Our results indicate that early-stage atherosclerosis may be associated with SSNHL, particularly in female patients more than 50 years old. |
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| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T08:09:38Z |
| publishDate | 2020-06-01 |
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| spelling | doaj.art-8f76db92c3c14d51a966d13b7815a0bb2023-12-02T23:30:14ZengPeerJ Inc.PeerJ2167-83592020-06-018e927610.7717/peerj.9276Association of carotid intima-media thickness with the risk of sudden sensorineural hearing lossChun-Hsien Ho0Teng-Yeow Tan1Chung-Feng Hwang2Wei-Che Lin3Ching-Nung Wu4Chao-Hui Yang5Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanCardiovascular factors are associated with the pathophysiological features and risk of sudden sensorineural hearing loss (SSNHL). However, little is known about the link between carotid intima-media thickness (IMT), SSNHL risk, and their respective treatment outcomes. In this study, we retrospectively reviewed 47 SSNHL cases and 33 control subjects from a single medical center and compared their demographic data and clinical characteristics, including their carotid IMT and audiological data. Of the 80 enrolled subjects, the proportion of those with high carotid IMT was greater in the SSNHL group (53.2%) than in the control group (21.2%), with an odds ratio (OR) of 4.22 (95% confidence interval (CI) [1.53–11.61], P = 0.004). Notably, high carotid IMT was more common in female SSNHL patients than females in the control group (54.2% vs. 12.5%; OR, 8.27 (95% CI [1.53–44.62]), P = 0.008), particularly in female patients ≥50 years of age (75% vs. 25%; OR, 9.0 (95% CI [1.27–63.9]), P = 0.032). The multivariate regression analyses showed the association between high carotid IMT and SSNHL with an adjusted OR of 4.655 (95% CI [1.348–16.076], P = 0.015), particularly in female SSNHL patients (adjusted OR, 9.818 (95% CI [1.064–90.587], P = 0.044). The carotid IMT was not associated with the treatment outcomes of SSNHL. Our results indicate that early-stage atherosclerosis may be associated with SSNHL, particularly in female patients more than 50 years old.https://peerj.com/articles/9276.pdfSudden sensorineural hearing lossCarotid intima-media thicknessAtherosclerosis |
| spellingShingle | Chun-Hsien Ho Teng-Yeow Tan Chung-Feng Hwang Wei-Che Lin Ching-Nung Wu Chao-Hui Yang Association of carotid intima-media thickness with the risk of sudden sensorineural hearing loss PeerJ Sudden sensorineural hearing loss Carotid intima-media thickness Atherosclerosis |
| title | Association of carotid intima-media thickness with the risk of sudden sensorineural hearing loss |
| title_full | Association of carotid intima-media thickness with the risk of sudden sensorineural hearing loss |
| title_fullStr | Association of carotid intima-media thickness with the risk of sudden sensorineural hearing loss |
| title_full_unstemmed | Association of carotid intima-media thickness with the risk of sudden sensorineural hearing loss |
| title_short | Association of carotid intima-media thickness with the risk of sudden sensorineural hearing loss |
| title_sort | association of carotid intima media thickness with the risk of sudden sensorineural hearing loss |
| topic | Sudden sensorineural hearing loss Carotid intima-media thickness Atherosclerosis |
| url | https://peerj.com/articles/9276.pdf |
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