Confirmation of canine acanthomatous ameloblastoma using RAS Q61R immunohistochemical staining of formalin-fixed paraffin-embedded tissues

Confirmation of canine acanthomatous ameloblastoma using RAS Q61R immunohistochemical staining of formalin-fixed paraffin-embedded tissues

Differentiating canine acanthomatous ameloblastoma (CAA) from oral squamous cell carcinoma (OSCC) based on routine histopathology can be challenging. We have previously shown that more than 95% of CAAs harbor an HRAS p.Q61R somatic mutation, while OSCCs carry either wild-type alleles or other MAPK p...

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Bibliographic Details
Main Authors: Santiago Peralta, Magdalena M. Marcinczyk, William P. Katt, Gerald E. Duhamel
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Veterinary Science
Subjects:
canine acanthomatous ameloblastoma
oral tumor
immunohistochemistry
HRAS
somatic mutation
SP174
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2023.1281022/full

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