Liquid Biopsy as a Prognostic and Theranostic Tool for the Management of Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinomas (PDAC) represent one of the deadliest cancers worldwide. Survival is still low due to diagnosis at an advanced stage and resistance to treatment. Herein, we review the main types of liquid biopsy able to help in both prognosis and adaptation of treatments.
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-01-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.788869/full |
| _version_ | 1828132825390383104 |
|---|---|
| author | Daniel C. Osei-Bordom Daniel C. Osei-Bordom Daniel C. Osei-Bordom Gagandeep Sachdeva Niki Christou Niki Christou Niki Christou |
| author_facet | Daniel C. Osei-Bordom Daniel C. Osei-Bordom Daniel C. Osei-Bordom Gagandeep Sachdeva Niki Christou Niki Christou Niki Christou |
| author_sort | Daniel C. Osei-Bordom |
| collection | DOAJ |
| description | Pancreatic ductal adenocarcinomas (PDAC) represent one of the deadliest cancers worldwide. Survival is still low due to diagnosis at an advanced stage and resistance to treatment. Herein, we review the main types of liquid biopsy able to help in both prognosis and adaptation of treatments. |
| first_indexed | 2024-04-11T17:09:15Z |
| format | Article |
| id | doaj.art-8f78e34bd7d149df82eb47886fd2260f |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-11T17:09:15Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-8f78e34bd7d149df82eb47886fd2260f2022-12-22T04:12:56ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-01-01810.3389/fmed.2021.788869788869Liquid Biopsy as a Prognostic and Theranostic Tool for the Management of Pancreatic Ductal AdenocarcinomaDaniel C. Osei-Bordom0Daniel C. Osei-Bordom1Daniel C. Osei-Bordom2Gagandeep Sachdeva3Niki Christou4Niki Christou5Niki Christou6Department of General Surgery, Queen Elizabeth Hospital, University Hospitals Birmingham, Birmingham, United KingdomInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United KingdomNational Institute for Health Research (NIHR) Birmingham Biomedical Research Centre, Centre for Liver and Gastroenterology Research, University of Birmingham, Birmingham, United KingdomInstitute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United KingdomDepartment of General Surgery, Queen Elizabeth Hospital, University Hospitals Birmingham, Birmingham, United KingdomDepartment of General Surgery, University Hospital of Limoges, Limoges, FranceEA3842 CAPTuR Laboratory “Cell Activation Control, Tumor Progression and Therapeutic Resistance”, Faculty of Medicine, Limoges, FrancePancreatic ductal adenocarcinomas (PDAC) represent one of the deadliest cancers worldwide. Survival is still low due to diagnosis at an advanced stage and resistance to treatment. Herein, we review the main types of liquid biopsy able to help in both prognosis and adaptation of treatments.https://www.frontiersin.org/articles/10.3389/fmed.2021.788869/fullpancreatic ductal adenocarcinomaliquid biopsyexosomesprognosispersonalized treatmentcirculating free DNA (cfDNA) |
| spellingShingle | Daniel C. Osei-Bordom Daniel C. Osei-Bordom Daniel C. Osei-Bordom Gagandeep Sachdeva Niki Christou Niki Christou Niki Christou Liquid Biopsy as a Prognostic and Theranostic Tool for the Management of Pancreatic Ductal Adenocarcinoma Frontiers in Medicine pancreatic ductal adenocarcinoma liquid biopsy exosomes prognosis personalized treatment circulating free DNA (cfDNA) |
| title | Liquid Biopsy as a Prognostic and Theranostic Tool for the Management of Pancreatic Ductal Adenocarcinoma |
| title_full | Liquid Biopsy as a Prognostic and Theranostic Tool for the Management of Pancreatic Ductal Adenocarcinoma |
| title_fullStr | Liquid Biopsy as a Prognostic and Theranostic Tool for the Management of Pancreatic Ductal Adenocarcinoma |
| title_full_unstemmed | Liquid Biopsy as a Prognostic and Theranostic Tool for the Management of Pancreatic Ductal Adenocarcinoma |
| title_short | Liquid Biopsy as a Prognostic and Theranostic Tool for the Management of Pancreatic Ductal Adenocarcinoma |
| title_sort | liquid biopsy as a prognostic and theranostic tool for the management of pancreatic ductal adenocarcinoma |
| topic | pancreatic ductal adenocarcinoma liquid biopsy exosomes prognosis personalized treatment circulating free DNA (cfDNA) |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.788869/full |
| work_keys_str_mv | AT danielcoseibordom liquidbiopsyasaprognosticandtheranostictoolforthemanagementofpancreaticductaladenocarcinoma AT danielcoseibordom liquidbiopsyasaprognosticandtheranostictoolforthemanagementofpancreaticductaladenocarcinoma AT danielcoseibordom liquidbiopsyasaprognosticandtheranostictoolforthemanagementofpancreaticductaladenocarcinoma AT gagandeepsachdeva liquidbiopsyasaprognosticandtheranostictoolforthemanagementofpancreaticductaladenocarcinoma AT nikichristou liquidbiopsyasaprognosticandtheranostictoolforthemanagementofpancreaticductaladenocarcinoma AT nikichristou liquidbiopsyasaprognosticandtheranostictoolforthemanagementofpancreaticductaladenocarcinoma AT nikichristou liquidbiopsyasaprognosticandtheranostictoolforthemanagementofpancreaticductaladenocarcinoma |