Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes

Abstract Background Genetic studies have associated thousands of enhancers with breast cancer (BC). However, the vast majority have not been functionally characterized. Thus, it remains unclear how BC-associated enhancers contribute to cancer. Results Here, we perform single-cell CRISPRi screens of...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Yihan Wang, Daniel A. Armendariz, Lei Wang, Huan Zhao, Shiqi Xie, Gary C. Hon
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: BMC 2025-01-01
Cyfres:Genome Biology
Pynciau:
Mynediad Ar-lein:https://doi.org/10.1186/s13059-025-03474-0