Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes

Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes

Abstract Background Genetic studies have associated thousands of enhancers with breast cancer (BC). However, the vast majority have not been functionally characterized. Thus, it remains unclear how BC-associated enhancers contribute to cancer. Results Here, we perform single-cell CRISPRi screens of...

Cijeli opis

Bibliografski detalji
Glavni autori: Yihan Wang, Daniel A. Armendariz, Lei Wang, Huan Zhao, Shiqi Xie, Gary C. Hon
Format: Članak
Jezik:English
Izdano: BMC 2025-01-01
Serija:Genome Biology
Teme:
Enhancers
Functional genomics
Cancer genomics
Regulatory networks
Breast cancer
Single-cell
Online pristup:https://doi.org/10.1186/s13059-025-03474-0

Internet

https://doi.org/10.1186/s13059-025-03474-0

Slični predmeti