Ixazomib Combined With Autologous Stem Cell Transplantation for POEMS Syndrome: A Case Report and Meta-Analysis
Objective: Polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes (POEMS) syndrome is a rare monoclonal plasma cell proliferation disorder. At present, there is no unified treatment for POEMS syndrome. Here, we describe one case with POEMS syndrome with obvious neurological symptoms d...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-12-01
|
| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338221123634 |
| _version_ | 1827978026488430592 |
|---|---|
| author | Ji Ma MD Xiaoyue Wang MM Hui Lu MM Zhihao Liang MM Liang Wang MD |
| author_facet | Ji Ma MD Xiaoyue Wang MM Hui Lu MM Zhihao Liang MM Liang Wang MD |
| author_sort | Ji Ma MD |
| collection | DOAJ |
| description | Objective: Polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes (POEMS) syndrome is a rare monoclonal plasma cell proliferation disorder. At present, there is no unified treatment for POEMS syndrome. Here, we describe one case with POEMS syndrome with obvious neurological symptoms diagnosed in September 2020. We made a meta-analysis to assess the efficacy of treatment strategies in recent years. Methods: We retrospectively analyzed the diagnosis and treatment of this patient, and searched relevant articles in PubMed, Embase, and MEDLINE databases using MedicalSubject Headings (MeSH) (eg, POEMS, Therapy, Drug Therapy, Biological Therapy, Combined Modality Therapy, Hematopoietic Stem Cell Transplantation, Immunotherapy, Molecular Targeted Therapy, Chemoradiotherapy, and Salvage Therapy) and free words, and performed the statistical analysis. Results: The patient's efficacy evaluation was complete response (CR) after treatment with ixazomib combined with autologous stem cell transplantation (ASCT). Overall, 20 articles consist of 6 clinical trials, 14 retrospective studies, and 936 patients were included in this meta-analysis. There was no significant difference in complete hematologic response (CR H ) rate between people who underwent ASCT and those who did not. However, ASCT might have a better survival rate. Conclusions: Ixazomib combined with ASCT therapy may be a safe and effective method for patients with POEMS syndrome. |
| first_indexed | 2024-04-09T21:15:17Z |
| format | Article |
| id | doaj.art-8f7c4f4b00f845d3a58a1824b288bbba |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-04-09T21:15:17Z |
| publishDate | 2022-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-8f7c4f4b00f845d3a58a1824b288bbba2023-03-28T11:05:10ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382022-12-012110.1177/15330338221123634Ixazomib Combined With Autologous Stem Cell Transplantation for POEMS Syndrome: A Case Report and Meta-AnalysisJi Ma MD0Xiaoyue Wang MM1Hui Lu MM2Zhihao Liang MM3Liang Wang MD4 Department of Medical Oncology, , , China Department of Hematology, , Dongying, China Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang, China Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang, China Department of Hematology, , Dongying, ChinaObjective: Polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes (POEMS) syndrome is a rare monoclonal plasma cell proliferation disorder. At present, there is no unified treatment for POEMS syndrome. Here, we describe one case with POEMS syndrome with obvious neurological symptoms diagnosed in September 2020. We made a meta-analysis to assess the efficacy of treatment strategies in recent years. Methods: We retrospectively analyzed the diagnosis and treatment of this patient, and searched relevant articles in PubMed, Embase, and MEDLINE databases using MedicalSubject Headings (MeSH) (eg, POEMS, Therapy, Drug Therapy, Biological Therapy, Combined Modality Therapy, Hematopoietic Stem Cell Transplantation, Immunotherapy, Molecular Targeted Therapy, Chemoradiotherapy, and Salvage Therapy) and free words, and performed the statistical analysis. Results: The patient's efficacy evaluation was complete response (CR) after treatment with ixazomib combined with autologous stem cell transplantation (ASCT). Overall, 20 articles consist of 6 clinical trials, 14 retrospective studies, and 936 patients were included in this meta-analysis. There was no significant difference in complete hematologic response (CR H ) rate between people who underwent ASCT and those who did not. However, ASCT might have a better survival rate. Conclusions: Ixazomib combined with ASCT therapy may be a safe and effective method for patients with POEMS syndrome.https://doi.org/10.1177/15330338221123634 |
| spellingShingle | Ji Ma MD Xiaoyue Wang MM Hui Lu MM Zhihao Liang MM Liang Wang MD Ixazomib Combined With Autologous Stem Cell Transplantation for POEMS Syndrome: A Case Report and Meta-Analysis Technology in Cancer Research & Treatment |
| title | Ixazomib Combined With Autologous Stem Cell Transplantation for POEMS Syndrome: A Case Report and Meta-Analysis |
| title_full | Ixazomib Combined With Autologous Stem Cell Transplantation for POEMS Syndrome: A Case Report and Meta-Analysis |
| title_fullStr | Ixazomib Combined With Autologous Stem Cell Transplantation for POEMS Syndrome: A Case Report and Meta-Analysis |
| title_full_unstemmed | Ixazomib Combined With Autologous Stem Cell Transplantation for POEMS Syndrome: A Case Report and Meta-Analysis |
| title_short | Ixazomib Combined With Autologous Stem Cell Transplantation for POEMS Syndrome: A Case Report and Meta-Analysis |
| title_sort | ixazomib combined with autologous stem cell transplantation for poems syndrome a case report and meta analysis |
| url | https://doi.org/10.1177/15330338221123634 |
| work_keys_str_mv | AT jimamd ixazomibcombinedwithautologousstemcelltransplantationforpoemssyndromeacasereportandmetaanalysis AT xiaoyuewangmm ixazomibcombinedwithautologousstemcelltransplantationforpoemssyndromeacasereportandmetaanalysis AT huilumm ixazomibcombinedwithautologousstemcelltransplantationforpoemssyndromeacasereportandmetaanalysis AT zhihaoliangmm ixazomibcombinedwithautologousstemcelltransplantationforpoemssyndromeacasereportandmetaanalysis AT liangwangmd ixazomibcombinedwithautologousstemcelltransplantationforpoemssyndromeacasereportandmetaanalysis |