Synergistic effects of silver nanoparticles and cisplatin in combating inflammation and hyperplasia of airway stents
Anti-inflammatory and antihyperplasia activities are essential requirements for the successful use of airway stents. In this work, silver nanoparticles (AgNPs) and cisplatin (DDP) were combined in a synergistic modification strategy to improve the surface function of airway stents. Using polycaprola...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-03-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X21003637 |
| _version_ | 1827280706807529472 |
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| author | Zhaonan Li Chuan Tian Dechao Jiao Jing Li Yahua Li Xueliang Zhou Huiping Zhao Yanan Zhao Xinwei Han |
| author_facet | Zhaonan Li Chuan Tian Dechao Jiao Jing Li Yahua Li Xueliang Zhou Huiping Zhao Yanan Zhao Xinwei Han |
| author_sort | Zhaonan Li |
| collection | DOAJ |
| description | Anti-inflammatory and antihyperplasia activities are essential requirements for the successful use of airway stents. In this work, silver nanoparticles (AgNPs) and cisplatin (DDP) were combined in a synergistic modification strategy to improve the surface function of airway stents. Using polycaprolactone (PCL) as a drug carrier, a dual-functional PCL-AgNPs-DDP fiber film-coated airway stent was fabricated by electrospinning. The physicochemical and biological properties of the obtained fiber films were examined. The ATR-FTIR, XPS, SEM-EDS and TEM results suggested that AgNPs and DDP could be successfully immobilized onto the airway stent surface. The drug release and surface degradation results revealed that AgNPs and DDP can undergo sustained release from films for 30 d, and the weight loss was approximately 50% after 35 d. In addition, the dual-functional fiber film suppressed human embryonic lung fibroblast growth and exhibited excellent antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. Furthermore, the effectiveness of the dual-functional fiber film-coated airway stent was evaluated by application to the trachea of New Zealand rabbits. The in vivo results indicated that PCL-AgNPs-DDP fiber film-coated airway stent can significantly inhibit granulation tissue formation and collagen deposition, reduced the expression of IL-8, TNF-α, IL-1α, PCNA, α-SMA and CD68, and ultimately achieved anti-inflammatory and antihyperplasia effects. Hence, this study provides a dual-functional surface-coated airway stent to address the clinical complications associated with respiratory tract inflammation and granulation tissue hyperplasia, thus inhibiting tracheal stenosis. |
| first_indexed | 2024-04-24T08:45:29Z |
| format | Article |
| id | doaj.art-8f7d12937ed343498be6c8014a3570a8 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:45:29Z |
| publishDate | 2022-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-8f7d12937ed343498be6c8014a3570a82024-04-16T13:36:49ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2022-03-019266280Synergistic effects of silver nanoparticles and cisplatin in combating inflammation and hyperplasia of airway stentsZhaonan Li0Chuan Tian1Dechao Jiao2Jing Li3Yahua Li4Xueliang Zhou5Huiping Zhao6Yanan Zhao7Xinwei Han8Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450001, PR ChinaDepartment of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450001, PR ChinaDepartment of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450001, PR ChinaDepartment of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450001, PR ChinaDepartment of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450001, PR ChinaDepartment of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450001, PR ChinaDepartment of Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450001, PR ChinaDepartment of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450001, PR China; Corresponding author. Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou, 450000, PR China.Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450001, PR China; Corresponding author. Department of Interventional Radiology, First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou, 450000, PR China.Anti-inflammatory and antihyperplasia activities are essential requirements for the successful use of airway stents. In this work, silver nanoparticles (AgNPs) and cisplatin (DDP) were combined in a synergistic modification strategy to improve the surface function of airway stents. Using polycaprolactone (PCL) as a drug carrier, a dual-functional PCL-AgNPs-DDP fiber film-coated airway stent was fabricated by electrospinning. The physicochemical and biological properties of the obtained fiber films were examined. The ATR-FTIR, XPS, SEM-EDS and TEM results suggested that AgNPs and DDP could be successfully immobilized onto the airway stent surface. The drug release and surface degradation results revealed that AgNPs and DDP can undergo sustained release from films for 30 d, and the weight loss was approximately 50% after 35 d. In addition, the dual-functional fiber film suppressed human embryonic lung fibroblast growth and exhibited excellent antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. Furthermore, the effectiveness of the dual-functional fiber film-coated airway stent was evaluated by application to the trachea of New Zealand rabbits. The in vivo results indicated that PCL-AgNPs-DDP fiber film-coated airway stent can significantly inhibit granulation tissue formation and collagen deposition, reduced the expression of IL-8, TNF-α, IL-1α, PCNA, α-SMA and CD68, and ultimately achieved anti-inflammatory and antihyperplasia effects. Hence, this study provides a dual-functional surface-coated airway stent to address the clinical complications associated with respiratory tract inflammation and granulation tissue hyperplasia, thus inhibiting tracheal stenosis.http://www.sciencedirect.com/science/article/pii/S2452199X21003637Anti-inflammatoryAntihyperplasiaAirway stentSilver nanoparticleCisplatin |
| spellingShingle | Zhaonan Li Chuan Tian Dechao Jiao Jing Li Yahua Li Xueliang Zhou Huiping Zhao Yanan Zhao Xinwei Han Synergistic effects of silver nanoparticles and cisplatin in combating inflammation and hyperplasia of airway stents Bioactive Materials Anti-inflammatory Antihyperplasia Airway stent Silver nanoparticle Cisplatin |
| title | Synergistic effects of silver nanoparticles and cisplatin in combating inflammation and hyperplasia of airway stents |
| title_full | Synergistic effects of silver nanoparticles and cisplatin in combating inflammation and hyperplasia of airway stents |
| title_fullStr | Synergistic effects of silver nanoparticles and cisplatin in combating inflammation and hyperplasia of airway stents |
| title_full_unstemmed | Synergistic effects of silver nanoparticles and cisplatin in combating inflammation and hyperplasia of airway stents |
| title_short | Synergistic effects of silver nanoparticles and cisplatin in combating inflammation and hyperplasia of airway stents |
| title_sort | synergistic effects of silver nanoparticles and cisplatin in combating inflammation and hyperplasia of airway stents |
| topic | Anti-inflammatory Antihyperplasia Airway stent Silver nanoparticle Cisplatin |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X21003637 |
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