A Closer Look at ACE2 Signaling Pathway and Processing during COVID-19 Infection: Identifying Possible Targets
Since the identification of its role as the functional receptor for SARS-CoV in 2003 and for SARS-CoV-2 in 2020, ACE2 has been studied in depth to understand COVID-19 susceptibility and severity. ACE2 is a widely expressed protein, and it plays a major regulatory role in the renin–angiotensin–aldost...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/11/1/13 |
| _version_ | 1797436621036978176 |
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| author | Pia V. Sodhi Francoise Sidime David D. Tarazona Faviola Valdivia Kelly S. Levano |
| author_facet | Pia V. Sodhi Francoise Sidime David D. Tarazona Faviola Valdivia Kelly S. Levano |
| author_sort | Pia V. Sodhi |
| collection | DOAJ |
| description | Since the identification of its role as the functional receptor for SARS-CoV in 2003 and for SARS-CoV-2 in 2020, ACE2 has been studied in depth to understand COVID-19 susceptibility and severity. ACE2 is a widely expressed protein, and it plays a major regulatory role in the renin–angiotensin–aldosterone System (RAAS). The key to understanding susceptibility and severity may be found in ACE2 variants. Some variants have been shown to affect binding affinity with SARS-CoV-2. In this review, we discuss the role of ACE2 in COVID-19 infection, highlighting the importance of ACE2 isoforms (soluble and membrane-bound) and explore how ACE2 variants may influence an individual’s susceptibility to SARS-CoV-2 infection and disease outcome. |
| first_indexed | 2024-03-09T11:05:17Z |
| format | Article |
| id | doaj.art-8f7d6c77c50544c4b69ecb85c1edb11b |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T11:05:17Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-8f7d6c77c50544c4b69ecb85c1edb11b2023-12-01T00:59:51ZengMDPI AGVaccines2076-393X2022-12-011111310.3390/vaccines11010013A Closer Look at ACE2 Signaling Pathway and Processing during COVID-19 Infection: Identifying Possible TargetsPia V. Sodhi0Francoise Sidime1David D. Tarazona2Faviola Valdivia3Kelly S. Levano4Ekarus, New York, NY 10023, USAEkarus, New York, NY 10023, USALaboratorio de Infecciones Respiratorias Agudas, Centro Nacional de Salud Pública, Instituto Nacional de Salud, Lima 15072, PeruLaboratorio de Infecciones Respiratorias Agudas, Centro Nacional de Salud Pública, Instituto Nacional de Salud, Lima 15072, PeruEkarus, New York, NY 10023, USASince the identification of its role as the functional receptor for SARS-CoV in 2003 and for SARS-CoV-2 in 2020, ACE2 has been studied in depth to understand COVID-19 susceptibility and severity. ACE2 is a widely expressed protein, and it plays a major regulatory role in the renin–angiotensin–aldosterone System (RAAS). The key to understanding susceptibility and severity may be found in ACE2 variants. Some variants have been shown to affect binding affinity with SARS-CoV-2. In this review, we discuss the role of ACE2 in COVID-19 infection, highlighting the importance of ACE2 isoforms (soluble and membrane-bound) and explore how ACE2 variants may influence an individual’s susceptibility to SARS-CoV-2 infection and disease outcome.https://www.mdpi.com/2076-393X/11/1/13COVID-19ACE2RAAS |
| spellingShingle | Pia V. Sodhi Francoise Sidime David D. Tarazona Faviola Valdivia Kelly S. Levano A Closer Look at ACE2 Signaling Pathway and Processing during COVID-19 Infection: Identifying Possible Targets Vaccines COVID-19 ACE2 RAAS |
| title | A Closer Look at ACE2 Signaling Pathway and Processing during COVID-19 Infection: Identifying Possible Targets |
| title_full | A Closer Look at ACE2 Signaling Pathway and Processing during COVID-19 Infection: Identifying Possible Targets |
| title_fullStr | A Closer Look at ACE2 Signaling Pathway and Processing during COVID-19 Infection: Identifying Possible Targets |
| title_full_unstemmed | A Closer Look at ACE2 Signaling Pathway and Processing during COVID-19 Infection: Identifying Possible Targets |
| title_short | A Closer Look at ACE2 Signaling Pathway and Processing during COVID-19 Infection: Identifying Possible Targets |
| title_sort | closer look at ace2 signaling pathway and processing during covid 19 infection identifying possible targets |
| topic | COVID-19 ACE2 RAAS |
| url | https://www.mdpi.com/2076-393X/11/1/13 |
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