Antisense Gapmers with LNA-Wings and (<i>S</i>)-5′-<i>C</i>-Aminopropyl-2′-arabinofluoro-nucleosides Could Efficiently Suppress the Expression of <i>KNTC2</i>

Antisense Gapmers with LNA-Wings and (<i>S</i>)-5′-<i>C</i>-Aminopropyl-2′-arabinofluoro-nucleosides Could Efficiently Suppress the Expression of <i>KNTC2</i>

Previously reported (<i>S</i>)-5′-<i>C</i>-aminopropyl-2′-arabinofluoro-thymidine (<b>5ara-T</b>) and newly synthesized (<i>S</i>)-5′-<i>C</i>-aminopropyl-2′-arabinofluoro-5-methyl-cytidine (<b>5ara-<sup>Me</sup>C</b>...

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Bibliographic Details
Main Authors: Yujun Zhou, Shuichi Sakamoto, Yoshihito Ueno
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
antisense oligonucleotides
5′-aminopropyl group
2′-arabinofluoro group
RNase H
phosphorothioate
locked nucleic acid
Online Access:https://www.mdpi.com/1420-3049/27/21/7384

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