Atypical intrinsic neural timescale in autism
How long neural information is stored in a local brain area reflects functions of that region and is often estimated by the magnitude of the autocorrelation of intrinsic neural signals in the area. Here, we investigated such intrinsic neural timescales in high-functioning adults with autism and exam...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-02-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/42256 |
| _version_ | 1811180547117940736 |
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| author | Takamitsu Watanabe Geraint Rees Naoki Masuda |
| author_facet | Takamitsu Watanabe Geraint Rees Naoki Masuda |
| author_sort | Takamitsu Watanabe |
| collection | DOAJ |
| description | How long neural information is stored in a local brain area reflects functions of that region and is often estimated by the magnitude of the autocorrelation of intrinsic neural signals in the area. Here, we investigated such intrinsic neural timescales in high-functioning adults with autism and examined whether local brain dynamics reflected their atypical behaviours. By analysing resting-state fMRI data, we identified shorter neural timescales in the sensory/visual cortices and a longer timescale in the right caudate in autism. The shorter intrinsic timescales in the sensory/visual areas were correlated with the severity of autism, whereas the longer timescale in the caudate was associated with cognitive rigidity. These observations were confirmed from neurodevelopmental perspectives and replicated in two independent cross-sectional datasets. Moreover, the intrinsic timescale was correlated with local grey matter volume. This study shows that functional and structural atypicality in local brain areas is linked to higher-order cognitive symptoms in autism. |
| first_indexed | 2024-04-11T09:05:05Z |
| format | Article |
| id | doaj.art-8f7f3955f15f4be4832f673fe8195cb8 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:05:05Z |
| publishDate | 2019-02-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-8f7f3955f15f4be4832f673fe8195cb82022-12-22T04:32:40ZengeLife Sciences Publications LtdeLife2050-084X2019-02-01810.7554/eLife.42256Atypical intrinsic neural timescale in autismTakamitsu Watanabe0https://orcid.org/0000-0002-8104-6873Geraint Rees1Naoki Masuda2Institute of Cognitive Neuroscience, University College London, London, United Kingdom; RIKEN Centre for Brain Science, Wako, JapanInstitute of Cognitive Neuroscience, University College London, London, United Kingdom; Wellcome Trust Centre for Human Neuroimaging, University College London, London, United KingdomDepartment of Engineering Mathematics, University of Bristol, Bristol, United KingdomHow long neural information is stored in a local brain area reflects functions of that region and is often estimated by the magnitude of the autocorrelation of intrinsic neural signals in the area. Here, we investigated such intrinsic neural timescales in high-functioning adults with autism and examined whether local brain dynamics reflected their atypical behaviours. By analysing resting-state fMRI data, we identified shorter neural timescales in the sensory/visual cortices and a longer timescale in the right caudate in autism. The shorter intrinsic timescales in the sensory/visual areas were correlated with the severity of autism, whereas the longer timescale in the caudate was associated with cognitive rigidity. These observations were confirmed from neurodevelopmental perspectives and replicated in two independent cross-sectional datasets. Moreover, the intrinsic timescale was correlated with local grey matter volume. This study shows that functional and structural atypicality in local brain areas is linked to higher-order cognitive symptoms in autism.https://elifesciences.org/articles/42256intrinsic timescaletemporal receptive windowautism spectrum disorderresting-state fMRIgrey matter volume |
| spellingShingle | Takamitsu Watanabe Geraint Rees Naoki Masuda Atypical intrinsic neural timescale in autism eLife intrinsic timescale temporal receptive window autism spectrum disorder resting-state fMRI grey matter volume |
| title | Atypical intrinsic neural timescale in autism |
| title_full | Atypical intrinsic neural timescale in autism |
| title_fullStr | Atypical intrinsic neural timescale in autism |
| title_full_unstemmed | Atypical intrinsic neural timescale in autism |
| title_short | Atypical intrinsic neural timescale in autism |
| title_sort | atypical intrinsic neural timescale in autism |
| topic | intrinsic timescale temporal receptive window autism spectrum disorder resting-state fMRI grey matter volume |
| url | https://elifesciences.org/articles/42256 |
| work_keys_str_mv | AT takamitsuwatanabe atypicalintrinsicneuraltimescaleinautism AT geraintrees atypicalintrinsicneuraltimescaleinautism AT naokimasuda atypicalintrinsicneuraltimescaleinautism |