Prevalence of methotrexate intolerance in juvenile idiopathic arthritis and possible risk factors: a tertiary center experience
Methotrexate that has a safe and inexpensive profile is a first choice of juvenile idiopathic arthritis treatment. Nevertheless, gastrointestinal symptoms are not serious but common side effects of methotrexate. Sometimes patients may have nausea by thinking methotrexate and even refuse methotrexate...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2022-08-01
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| Series: | The Journal of Pediatric Academy |
| Subjects: | |
| Online Access: | https://jpediatricacademy.com/index.php/jpa/article/view/184 |
| _version_ | 1827888753741398016 |
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| author | Zahide Ekici Tekin Melike Mehveş Kaplan Merve Cansu Polat Elif Çelikel Vildan Güngörer Tuba Kurt Nilüfer Tekgöz Müge Sezer Cüneyt Karagöl Serkan Coşkun Nimet Öner Banu Çelikel Acae |
| author_facet | Zahide Ekici Tekin Melike Mehveş Kaplan Merve Cansu Polat Elif Çelikel Vildan Güngörer Tuba Kurt Nilüfer Tekgöz Müge Sezer Cüneyt Karagöl Serkan Coşkun Nimet Öner Banu Çelikel Acae |
| author_sort | Zahide Ekici Tekin |
| collection | DOAJ |
| description | Methotrexate that has a safe and inexpensive profile is a first choice of juvenile idiopathic arthritis treatment. Nevertheless, gastrointestinal symptoms are not serious but common side effects of methotrexate. Sometimes patients may have nausea by thinking methotrexate and even refuse methotrexate use. In this study, we aimed to define prevalence of methotrexate side effects in juvenile idiopathic arthritis and the possible risk factors for methotrexate intolerance. Methotrexate intolerance severity score showed severity of gastrointestinal symptoms. Eighty-seven patients accepted to join study and answered the questions. The prevalence of adverse events of methotrexate was 64.4% and the rate of gastrointestinal symptoms was 55.2%. The nausea (27.6%) was the most common gastrointestinal symptom. The median of methotrexate intolerance severity score was 14.5 (interquartile range: 10-18). However, there was no significant difference in main parameters between tolerant and intolerant groups and no risk factor was observed for methotrexate intolerance. As a conclusion, methotrexate is an important actor for juvenile idiopathic arthritis treatment as a first and safe drug and, prospective studies in larger cohorts is necessary to understand and prevent occurrence of gastrointestinal symptoms. |
| first_indexed | 2024-03-12T20:38:17Z |
| format | Article |
| id | doaj.art-8f7f854ed2aa43a68917ce3735c86cb7 |
| institution | Directory Open Access Journal |
| issn | 2718-0875 |
| language | English |
| last_indexed | 2024-03-12T20:38:17Z |
| publishDate | 2022-08-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | The Journal of Pediatric Academy |
| spelling | doaj.art-8f7f854ed2aa43a68917ce3735c86cb72023-08-01T11:23:15ZengGalenos Publishing HouseThe Journal of Pediatric Academy2718-08752022-08-0132606410.51271/jpea-2022-184134Prevalence of methotrexate intolerance in juvenile idiopathic arthritis and possible risk factors: a tertiary center experienceZahide Ekici Tekin0Melike Mehveş Kaplan1Merve Cansu Polat2Elif Çelikel3Vildan Güngörer4Tuba Kurt5Nilüfer Tekgöz6Müge Sezer7Cüneyt Karagöl8Serkan Coşkun9Nimet Öner10Banu Çelikel Acae11Ankara City HospitalAnkara City HospitalAnkara City HospitalAnkara City HospitalAnkara City HospitalAnkara City HospitalAnkara City HospitalAnkara City HospitalAnkara City HospitalAnkara City HospitalAnkara City HospitalAnkara City HospitalMethotrexate that has a safe and inexpensive profile is a first choice of juvenile idiopathic arthritis treatment. Nevertheless, gastrointestinal symptoms are not serious but common side effects of methotrexate. Sometimes patients may have nausea by thinking methotrexate and even refuse methotrexate use. In this study, we aimed to define prevalence of methotrexate side effects in juvenile idiopathic arthritis and the possible risk factors for methotrexate intolerance. Methotrexate intolerance severity score showed severity of gastrointestinal symptoms. Eighty-seven patients accepted to join study and answered the questions. The prevalence of adverse events of methotrexate was 64.4% and the rate of gastrointestinal symptoms was 55.2%. The nausea (27.6%) was the most common gastrointestinal symptom. The median of methotrexate intolerance severity score was 14.5 (interquartile range: 10-18). However, there was no significant difference in main parameters between tolerant and intolerant groups and no risk factor was observed for methotrexate intolerance. As a conclusion, methotrexate is an important actor for juvenile idiopathic arthritis treatment as a first and safe drug and, prospective studies in larger cohorts is necessary to understand and prevent occurrence of gastrointestinal symptoms.https://jpediatricacademy.com/index.php/jpa/article/view/184juvenile idiopathic arthritismethotrexateintolerancenausea |
| spellingShingle | Zahide Ekici Tekin Melike Mehveş Kaplan Merve Cansu Polat Elif Çelikel Vildan Güngörer Tuba Kurt Nilüfer Tekgöz Müge Sezer Cüneyt Karagöl Serkan Coşkun Nimet Öner Banu Çelikel Acae Prevalence of methotrexate intolerance in juvenile idiopathic arthritis and possible risk factors: a tertiary center experience The Journal of Pediatric Academy juvenile idiopathic arthritis methotrexate intolerance nausea |
| title | Prevalence of methotrexate intolerance in juvenile idiopathic arthritis and possible risk factors: a tertiary center experience |
| title_full | Prevalence of methotrexate intolerance in juvenile idiopathic arthritis and possible risk factors: a tertiary center experience |
| title_fullStr | Prevalence of methotrexate intolerance in juvenile idiopathic arthritis and possible risk factors: a tertiary center experience |
| title_full_unstemmed | Prevalence of methotrexate intolerance in juvenile idiopathic arthritis and possible risk factors: a tertiary center experience |
| title_short | Prevalence of methotrexate intolerance in juvenile idiopathic arthritis and possible risk factors: a tertiary center experience |
| title_sort | prevalence of methotrexate intolerance in juvenile idiopathic arthritis and possible risk factors a tertiary center experience |
| topic | juvenile idiopathic arthritis methotrexate intolerance nausea |
| url | https://jpediatricacademy.com/index.php/jpa/article/view/184 |
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