Novel subcellular localization for alpha-synuclein: possible functional consequences

Novel subcellular localization for alpha-synuclein: possible functional consequences

α−Synuclein (α-syn) is one of the genes that when mutated or overexpressed causes Parkinson’s Disease (PD). Initially, it was described as a synaptic terminal protein and later was found to be localized at mitochondria. Mitochondria-associated membranes (MAM) have emerged as a central endoplasmic re...

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Bibliographic Details
Main Authors: Cristina eGuardia-Laguarta, Estela eArea-Gomez, Eric A Schon, Serge ePrzedborski
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Neuroanatomy
Subjects:
alpha-Synuclein
Endoplasmic Reticulum
Parkinson's disease
phospholipid
Mitochondria-associated membranes
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnana.2015.00017/full

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