Integrated analysis of DNA-methylation and gene expression using high-dimensional penalized regression: a cohort study on bone mineral density in postmenopausal women

Integrated analysis of DNA-methylation and gene expression using high-dimensional penalized regression: a cohort study on bone mineral density in postmenopausal women

Abstract Background Using high-dimensional penalized regression we studied genome-wide DNA-methylation in bone biopsies of 80 postmenopausal women in relation to their bone mineral density (BMD). The women showed BMD varying from severely osteoporotic to normal. Global gene expression data from the...

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Bibliographic Details
Main Authors: Tonje G. Lien, Ørnulf Borgan, Sjur Reppe, Kaare Gautvik, Ingrid Kristine Glad
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Medical Genomics
Subjects:
Bone
DNA-methylation
Gene expression
Individual penalties
Integration
Lasso
Online Access:http://link.springer.com/article/10.1186/s12920-018-0341-2

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