Reduced maximal range of ocular movements and its response to acute levodopa challenge in Parkinson's disease
IntroductionAlthough restriction of vertical ocular range of motion is known to be the hallmark of progressive supranuclear palsy (PSP), the maximal amplitude of ocular movement has not been quantitatively assessed despite of accumulating evidences of oculomotor dysfunction in Parkinson's disea...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-03-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1368539/full |
| _version_ | 1797256569398755328 |
|---|---|
| author | Juan Li Yuewen Li Xianzhou Chu Mengxue Jiang Tieyu Wu Xianwen Chen |
| author_facet | Juan Li Yuewen Li Xianzhou Chu Mengxue Jiang Tieyu Wu Xianwen Chen |
| author_sort | Juan Li |
| collection | DOAJ |
| description | IntroductionAlthough restriction of vertical ocular range of motion is known to be the hallmark of progressive supranuclear palsy (PSP), the maximal amplitude of ocular movement has not been quantitatively assessed despite of accumulating evidences of oculomotor dysfunction in Parkinson's disease (PD). Here, we evaluated the maximal oculomotor range and its response to levodopa in PD, and compare findings to atypical parkinsonism.MethodsWe recruited 159 healthy controls (HC) as well as 154 PD, 30 PSP, and 16 multiple system atrophy (MSA) patients. Oculomotor range was assessed using a kinetic perimeter-adapted device for the vertical and horizontal axes (four positions). Parameters were reassessed after levodopa challenge and compared among PD, PSP, and MSA patients.ResultsMaximum oculomotor range in PD patients was reduced as compared to HC. Levodopa improved oculomotor range in all directions; corrective effects of upward range positively correlated with improvements in Unified Parkinson's Disease Rating Scale III and bradykinesia sub-scores among PD patients. Although oculomotor range was markedly restricted among PSP and MSA patients, the beneficial effects of levodopa was less pronounced. Reduced oculomotor range of motion was more significant among PSP as compared to PD or MSA patients; MSA patients did not significantly differ from PD patients. The range of upward gaze was optimally sensitive for differentiating among PD, PSP, and MSA patients.ConclusionMaximum oculomotor range was reduced among PD patients significantly improved by levodopa treatment. Variations in, as well as the positively effects of levodopa on, the range of upward gaze assist diagnostic differentiation among PD, PSP, and MSA patients. |
| first_indexed | 2024-04-24T22:23:50Z |
| format | Article |
| id | doaj.art-8f8171e709854b6c88a3a0df0cc43879 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-24T22:23:50Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-8f8171e709854b6c88a3a0df0cc438792024-03-20T04:37:18ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652024-03-011610.3389/fnagi.2024.13685391368539Reduced maximal range of ocular movements and its response to acute levodopa challenge in Parkinson's diseaseJuan Li0Yuewen Li1Xianzhou Chu2Mengxue Jiang3Tieyu Wu4Xianwen Chen5Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaIntroductionAlthough restriction of vertical ocular range of motion is known to be the hallmark of progressive supranuclear palsy (PSP), the maximal amplitude of ocular movement has not been quantitatively assessed despite of accumulating evidences of oculomotor dysfunction in Parkinson's disease (PD). Here, we evaluated the maximal oculomotor range and its response to levodopa in PD, and compare findings to atypical parkinsonism.MethodsWe recruited 159 healthy controls (HC) as well as 154 PD, 30 PSP, and 16 multiple system atrophy (MSA) patients. Oculomotor range was assessed using a kinetic perimeter-adapted device for the vertical and horizontal axes (four positions). Parameters were reassessed after levodopa challenge and compared among PD, PSP, and MSA patients.ResultsMaximum oculomotor range in PD patients was reduced as compared to HC. Levodopa improved oculomotor range in all directions; corrective effects of upward range positively correlated with improvements in Unified Parkinson's Disease Rating Scale III and bradykinesia sub-scores among PD patients. Although oculomotor range was markedly restricted among PSP and MSA patients, the beneficial effects of levodopa was less pronounced. Reduced oculomotor range of motion was more significant among PSP as compared to PD or MSA patients; MSA patients did not significantly differ from PD patients. The range of upward gaze was optimally sensitive for differentiating among PD, PSP, and MSA patients.ConclusionMaximum oculomotor range was reduced among PD patients significantly improved by levodopa treatment. Variations in, as well as the positively effects of levodopa on, the range of upward gaze assist diagnostic differentiation among PD, PSP, and MSA patients.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1368539/fullParkinson's diseaseoculomotor rangeprogressive supranuclear palsymultiple system atrophydifferential diagnosis |
| spellingShingle | Juan Li Yuewen Li Xianzhou Chu Mengxue Jiang Tieyu Wu Xianwen Chen Reduced maximal range of ocular movements and its response to acute levodopa challenge in Parkinson's disease Frontiers in Aging Neuroscience Parkinson's disease oculomotor range progressive supranuclear palsy multiple system atrophy differential diagnosis |
| title | Reduced maximal range of ocular movements and its response to acute levodopa challenge in Parkinson's disease |
| title_full | Reduced maximal range of ocular movements and its response to acute levodopa challenge in Parkinson's disease |
| title_fullStr | Reduced maximal range of ocular movements and its response to acute levodopa challenge in Parkinson's disease |
| title_full_unstemmed | Reduced maximal range of ocular movements and its response to acute levodopa challenge in Parkinson's disease |
| title_short | Reduced maximal range of ocular movements and its response to acute levodopa challenge in Parkinson's disease |
| title_sort | reduced maximal range of ocular movements and its response to acute levodopa challenge in parkinson s disease |
| topic | Parkinson's disease oculomotor range progressive supranuclear palsy multiple system atrophy differential diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1368539/full |
| work_keys_str_mv | AT juanli reducedmaximalrangeofocularmovementsanditsresponsetoacutelevodopachallengeinparkinsonsdisease AT yuewenli reducedmaximalrangeofocularmovementsanditsresponsetoacutelevodopachallengeinparkinsonsdisease AT xianzhouchu reducedmaximalrangeofocularmovementsanditsresponsetoacutelevodopachallengeinparkinsonsdisease AT mengxuejiang reducedmaximalrangeofocularmovementsanditsresponsetoacutelevodopachallengeinparkinsonsdisease AT tieyuwu reducedmaximalrangeofocularmovementsanditsresponsetoacutelevodopachallengeinparkinsonsdisease AT xianwenchen reducedmaximalrangeofocularmovementsanditsresponsetoacutelevodopachallengeinparkinsonsdisease |