The Role of Gut Microbiota in Heart Failure: When Friends Become Enemies
Heart failure is a complex health issue, with important consequences on the overall wellbeing of patients. It can occur both in acute and chronic forms and, in the latter, the immune system appears to play an important role in the pathogenesis of the disease. In particular, in the forms with preserv...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/11/2712 |
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| author | Rossella Cianci Laura Franza Raffaele Borriello Danilo Pagliari Antonio Gasbarrini Giovanni Gambassi |
| author_facet | Rossella Cianci Laura Franza Raffaele Borriello Danilo Pagliari Antonio Gasbarrini Giovanni Gambassi |
| author_sort | Rossella Cianci |
| collection | DOAJ |
| description | Heart failure is a complex health issue, with important consequences on the overall wellbeing of patients. It can occur both in acute and chronic forms and, in the latter, the immune system appears to play an important role in the pathogenesis of the disease. In particular, in the forms with preserved ejection fraction or with only mildly reduced ejection fraction, some specific associations with chronic inflammatory diseases have been observed. Another interesting aspect that is worth considering is the role of microbiota modulation, in this context: given the importance of microbiota in the modulation of immune responses, it is possible that changes in its composition may somewhat influence the progression and even the pathogenesis of heart failure. In this narrative review, we aim to examine the relationship between immunity and heart failure, with a special focus on the role of microbiota in this pathological condition. |
| first_indexed | 2024-03-09T19:15:18Z |
| format | Article |
| id | doaj.art-8f83f1167d0443d1ab66b49531d53d4c |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T19:15:18Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-8f83f1167d0443d1ab66b49531d53d4c2023-11-24T03:49:30ZengMDPI AGBiomedicines2227-90592022-10-011011271210.3390/biomedicines10112712The Role of Gut Microbiota in Heart Failure: When Friends Become EnemiesRossella Cianci0Laura Franza1Raffaele Borriello2Danilo Pagliari3Antonio Gasbarrini4Giovanni Gambassi5Department of Translational Medicine and Surgery, Catholic University of Rome, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, ItalyEmergency Medicine Unit, Catholic University of Rome, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Catholic University of Rome, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, ItalyMedical Officer of the Carabinieri Corps, Health Service of the Carabinieri General Headquarters, 00197 Rome, ItalyDepartment of Translational Medicine and Surgery, Catholic University of Rome, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Catholic University of Rome, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, ItalyHeart failure is a complex health issue, with important consequences on the overall wellbeing of patients. It can occur both in acute and chronic forms and, in the latter, the immune system appears to play an important role in the pathogenesis of the disease. In particular, in the forms with preserved ejection fraction or with only mildly reduced ejection fraction, some specific associations with chronic inflammatory diseases have been observed. Another interesting aspect that is worth considering is the role of microbiota modulation, in this context: given the importance of microbiota in the modulation of immune responses, it is possible that changes in its composition may somewhat influence the progression and even the pathogenesis of heart failure. In this narrative review, we aim to examine the relationship between immunity and heart failure, with a special focus on the role of microbiota in this pathological condition.https://www.mdpi.com/2227-9059/10/11/2712heart failuregut microbiotainnate immunityadaptive immunityimmune modulation |
| spellingShingle | Rossella Cianci Laura Franza Raffaele Borriello Danilo Pagliari Antonio Gasbarrini Giovanni Gambassi The Role of Gut Microbiota in Heart Failure: When Friends Become Enemies Biomedicines heart failure gut microbiota innate immunity adaptive immunity immune modulation |
| title | The Role of Gut Microbiota in Heart Failure: When Friends Become Enemies |
| title_full | The Role of Gut Microbiota in Heart Failure: When Friends Become Enemies |
| title_fullStr | The Role of Gut Microbiota in Heart Failure: When Friends Become Enemies |
| title_full_unstemmed | The Role of Gut Microbiota in Heart Failure: When Friends Become Enemies |
| title_short | The Role of Gut Microbiota in Heart Failure: When Friends Become Enemies |
| title_sort | role of gut microbiota in heart failure when friends become enemies |
| topic | heart failure gut microbiota innate immunity adaptive immunity immune modulation |
| url | https://www.mdpi.com/2227-9059/10/11/2712 |
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